Category: 1735-88-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide, A new synthetic method of this compound is introduced below., COA of Formula: C9H7FN2O

The compound prepared in step 1 (480 mg, 3.93 mmol) and the compound prepared in step 2 (538 mg, 3.02 mmol) were dissolved in N, N-dimethylformamide, and then piperidine (0.06 mL, 0.60 mmol) ) And acetic acid (0.23 mL, 3.93 mmol) were added sequentially, followed by stirring at 135 C. for 12 hours. After cooling to room temperature, extracted with ethyl acetate, the separated organic layer was dried over anhydrous sodium sulfate, and the residue obtained by concentrating the solvent under reduced pressure was purified by column chromatography to obtain the title compound (411 mg, yield: 56%, orange solid).

The synthetic route of 1735-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Welmakeo Bio Co., Ltd.; Lee Hyeon-ho; Park Jun-ho; Huh Seon-cheol; Moon Jae-hui; Shin Jae-sik; Hong Seung-u; Park Yun-seon; Kim Yo-sep; Lee So-hui; Kim Hyo-jin; Park Hye-bin; (48 pag.)KR2019/106802; (2019); A;,
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Nitriles – Chemistry LibreTexts

Reference of 1735-88-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.

Step 3: Preparation of 2-cyano-N-(4-fluorophenyl)-3-[5-(2,5,8-trioxa-nonyl-1-yl)furan-2-yl]-2-acrylamide (JK-06A) 2-cyano-N-(4-fluorophenyl)acetamide (4.0 g, 22.4 mmol), 5-(2,5,8-trioxa-nonyl-1-yl)furan-2-carbaldehyde (3.4 g, 14.9 mmol) and 1-methylpiperazine (2.2 g, 22.4 mmol) were dissolved in CH3OH (50 mL), stirred at room temperature overnight. The solid was collected by filtration, washed with CH3OH (50 mL) to give 1.6 g of a yellow solid with a yield of 27.6%. MS Detection: MASS(ESI+) m/z=411.3 (M+Na)+.

The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N-(4-fluorophenyl)acetamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; JENKEM TECHNOLOGY CO., LTD. (BEIJING); FENG, ZEWANG; JIA, JIANHUAN; LIU, YAN; WANG, ZHENGUO; ZHAO, XUAN; (13 pag.)US2016/272604; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide, molecular formula is C9H7FN2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H7FN2O

A mixture of N-(4-fluorophenyl)cyanoacctamide (1 equiv.), hydroxylamine hydrochloride (2 equiv.) and tricthylamine (2 equiv.) in DMF was heated to 50-60nC for 4 h th«n diluted with water and the product filtered off and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1735-88-2, its application will become more common.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2008/70891; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1735-88-2, A common heterocyclic compound, 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide, molecular formula is C9H7FN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: By applying a two-steps Gewald synthesis, a mixture of the appropriate 2-cyano-N-(substituted)acetamide (1.0 equiv), cycloheptanone (4.0 equiv), ammonium acetate (1.3 equiv), and glacial acetic acid (3.5 equiv) in benzene (10mL/mmol) was heated at reflux for 16h in a Dean-Stark apparatus. After cooling, the mixture was diluted with CHCl3 and then washed with H2O, 10% NaCO3 solution, and finally H2O. The organic layer was concentrated to dryness to afford the crude Knoevenagel product, which was used directly in the successive step without further purification. Thus, to the crude Knoevenagel product (1.0 equiv) dissolved in EtOH, sulfur (4.0 equiv) and N,N-diethylamine (4.0 equiv) were added. The mixture was maintained at 40-50C for 2h and then concentrated to dryness to yield a residue, which was treated with a mixture of cyclohexane/Et2O and filtered.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Desantis, Jenny; Nannetti, Giulio; Massari, Serena; Barreca, Maria Letizia; Manfroni, Giuseppe; Cecchetti, Violetta; Palu, Giorgio; Goracci, Laura; Loregian, Arianna; Tabarrini, Oriana; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 128 – 139;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1735-88-2, name is 2-Cyano-N-(4-fluorophenyl)acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C9H7FN2O

EXAMPLE 7; Preparation of3-(5-trifluoromethyl-l, 2, 4-oxadiazol-3-yl)-l-(4-fluorophenyl)-5- methylene-2-oxo-4-methyl-2,5-dihydro-lH-pyrrole (Compound 245); The following compounds were prepared according to reaction schemes 7 and 12.(a) A mixture of iV-(4-fluorophenyl)cyanoacetamide (1 equiv.), hydroxylamine hydrochloride (2 equiv.) and triethylamine (2 equiv.) in DMF was heated to 50-600C for 4 h then diluted with water and the product filtered off and dried.

The synthetic route of 1735-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2008/70934; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1735-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1735-88-2 name is 2-Cyano-N-(4-fluorophenyl)acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-cyano-N-(4-fluorophenyl)acetamide (1.78 g, 0.01 mol) in ethanol (20ml) was added piperidine and 3,4-dihydroxy-5-nitrobenzaldehyde (1.83 g, 0.01 mol). The reaction mass was heated to 70-75 C for 2-3 hours. After completion of the reaction, the solid that formed was filtered off. To the solid was added demineralized water and the mixture was neutralized using diluted HCl. The residue was filtered off to afford the pure compound, which had a melting point of 250.3 – 253.9 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N-(4-fluorophenyl)acetamide, and friends who are interested can also refer to it.

Reference:
Patent; GEORGETOWN UNIVERSITY; ALKEM LABORATORIES LIMITED; PADMANABHAN, Radhakrishnan; NAGARAJAN, Kuppuswamy; RAO, Kothapalli Sundarraja; SHRIDHARA, Kanakamajalu; SHASHIPRABHA, .; HARISHA, Attimogae Shivamurthy; WO2014/164667; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1735-88-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1735-88-2 name is 2-Cyano-N-(4-fluorophenyl)acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-cyano-N- (4-fluorophenyl) acetamide (2 g, 11.2 mmol) and (3E) -4-ethoxy-l, 1, 1-trifluorobut-3-en-2-one (2.26 g, 13.4 mmol) in dimethyleneglycol monomethylether (20 mL) was added 1, 4-diazabicyclo [2.2.2] octane (1.26 g, 11.2 mmol), and the mixture was stirred at 120C for 6 hr. The reaction mixture was diluted with IN hydrochloric acid and ethyl acetate, and the mixture was extracted 3 times with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (NH silica gel, ethyl acetate/hexane=l/2->1/1) to give a white solid. The white solid was washed with ethyl acetate and collected by filtration to give the title compound (230 mg, 7.2%) as a white solid. 1H-NMR (DMSOd6, 300 MHz) delta 7.13 (IH, d, J = 7.6 Hz), 7.32 – 7.46 (2H, m) , 7.49 – 7.60 (2H, m) , 8.44 (IH, d, J = 7.4 Hz) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyano-N-(4-fluorophenyl)acetamide, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/136663; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts