172921-32-3, A common compound: 172921-32-3, name is 2,5-Difluoro-4-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Add 680 g of cyanide to the reaction vessel. 15% sodium hydroxide solution 340 g, Stir, heat, reflux at around 95, GC tracking until the reaction is over, slightly cold, Add hydrochloric acid under stirring to adjust the pH of the solution to about 1, slightly cold, Pour into ice water to precipitate a solid product, suction filtration, and dry. Obtained 518 g of a white solid. The content is more than 97%, and the yield is 76%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Difluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Changzhou University; Chen Xingquan; Dong Yanmin; (5 pag.)CN109369412; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts