Category: 17216-62-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 17216-62-5

(a) Diethyl 2-(2-cyanoethyl)-2-(5-nitropyrid-2-yl)malonate Sodium hydride (53% dispersion in oil) (30.71 g, 0.66 mole) was washed by decantation with xylene (2*150 ml), ether (150 ml), tetrahydrofuran (THF) (150 ml) and finally suspended in THF (245 ml). Diethyl 2-(2-cyanoethyl) malonate (156 g, 0.73 mole) in THF (80 ml) was added dropwise over 1 hr keeping the internal temperature at 18 C. to 22 C. (with ice bath cooling). The resulting suspension cleared over 15 minutes when 2-chloro-5-nitropyridine (88.3 g, 0.55 mole) was added to give a deep magenta solution. The resulting solution was refluxed for 1 hr and the solvent was removed on the rotary evaporator. The resulting oil was partitioned between water (500 ml) and chloroform (800 ml), the pH was adjusted to ~7 (concentrated hydrochloric acid), and the chloroform was run off. The aqueous layer was extracted with a further (2*250 ml) chloroform, the extracts were combined, dried over magnesium sulphate and the solvent was removed to give an amber oil (~245 g). Ether (150 ml) was added and the solution was allowed to crystallise to give the title compound (121.98 g, 65%), m.p. 59.5-61 C. (Found C, 53.7; H. 5.05; N, 12.35%. C15 H17 N3 O6 requires C, 53.75; H, 5.1; N, 12.55%) NMR (CDCl3, 60 MHz); delta 1.37 (6 H, t); 2.65 (4 H, m); 4.26 (4 H, q); 7.84 (1 H, dd); 8.49 (1 H, dd); 9.32 (1 H, dd).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17216-62-5.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4902698; (1990); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 17216-62-5, The chemical industry reduces the impact on the environment during synthesis 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, I believe this compound will play a more active role in future production and life.

(a) 2-(2-Cyanoethyl)malonic acid diethylester (40 g) was reacted with sodium hydride (4.4 gm) in tetrahydrofuran at 20 C. 2-Chloro-5-methyl-3-nitro-pyridine (35 g) was added and the internal temperature was raised to 100 C. (some tetrahydrofuran distilled off) over 4.25 hrs. The reaction mixture was partitioned between chloroform and water and treated with charcoal. Vacuum distillation of the chloroform extract and then chromatography (CHCl3, silica column) of the distillation residues gave 4-(5-methyl-3-nitropyrid-2-yl)-4,4-bis (carbethoxy)-butyronitrile (24.5 g) as a yellow solid m.p. 48-49 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-(2-cyanoethyl)malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4444772; (1984); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17216-62-5, category: nitriles-buliding-blocks

(a) 4-Cyano-2(R,S)-alpha-naphthylmethylbutyric acid 2.13 g of 2-cyanoethylmalonic acid diethyl ester are added to a suspension of 0.48 g of sodium hydride dispersion in 25 ml of DMF. The reaction mixture is stirred for 2 hours at 80 and then, at room temperature, 1.77 g of alpha-chloromethylnaphthalene in 5 ml of DMF are added. The mixture is further stirred for 16 hours at 50 and then concentrated by evaporation. The residue is dissolved in ethyl acetate, washed with 0.1N hydrochloric acid and water, dried over sodium sulphate and concentrated by evaporation, leaving 2-cyanoethyl-alpha-naphthylmethylmalonic acid diethyl ester.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Diethyl 2-(2-cyanoethyl)malonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ciba-Geigy Corporation; US4727060; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of Diethyl 2-(2-cyanoethyl)malonate

(a) Diethyl 2-(2-cyanoethyl)-2-(5-nitropyrid-2-yl)malonate Sodium hydride (53% dispersion in oil) (30.71g, 0.66mole) was washed by decantation with xylene (2 * 150ml), ether (150ml), tetrahydrofuran (THF) (150ml) and finally suspended in THF (245ml). Diethyl 2-(2-cyanoethyl) malonate (156g. 0.73mole) in THF (80ml) was added dropwise over 1hr keeping the internal temperature at 18C to 22C (with ice bath cooling). The resulting suspension cleared over 15 minutes when 2-chloro-5-nitropyridine (88.3g, 0.55mole) was added to give a deep magenta solution. The resulting solution was refluxed for 1hr and the solvent was removed on the rotary evaporator. The resulting oil was partitioned between water (500ml) and chloroform (800ml), the pH was adjusted to ~7 (concentrated hydrochloric acid), and the chloroform was run off. The aqueous layer was extracted with a further (2 * 250ml) chloroform, the extracts were combined, dried over magnesium sulphate and the solvent was removed to give an amber oil (~245g). Ether (150ml) was added and the solution was allowed to crystallise to give the title compound (121.98g, 65%), m.p. 59.5-61C. (Found C, 53.7: H, 5.05; N, 12.35%. C15H17N3O6 requires C, 53.75; H, 5.1: N, 12.55%) NM, (CDCl3, 60 MHz); delta 1,37 (6H, t); 2.65 (4H, m); 4.26 (4H, q); 7.84 (1H, dd); 8,49 (1H, dd); 9.32 (1H, dd).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 17216-62-5.

Reference:
Patent; SMITH KLINE & FRENCH LABORATORIES, LIMITED; EP287270; (1988); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

17216-62-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, A new synthetic method of this compound is introduced below.

241 kg of the above intermediate, 1200 kg of isopropyl alcohol and 28 kg of catalyst Raney Co were placed in a 2-liter stainless steel autoclave. After replacing the air in the kettle with hydrogen,Press the hydrogen pressure to 25kg/cm2, turn on the stirring, and slowly raise the temperature to 70 C with jacketed steam.Above, the oxygen inhalation reaction begins to exotherm. At this point, turn on the cooling water to cool.The reaction temperature was controlled to rise smoothly to 90-100 C, and the introduction of hydrogen gas was controlled to stabilize the pressure at 35-40 kg/cm 2 .After 4.5 hours, the hydrogen absorption was stopped and the reaction was continued at 100 C, 35 kg / cm 2 for 1 hour.The material in the autoclave was cooled to 44 C with cooling water, and after the residual hydrogen pressure was vented,Press the material to the filter with N2 gas.The Raney Co catalyst was recovered by filtration under N2 gas protection.The filtrate was introduced into a 2000 liter glass-line distillation crystallization kettle, and heated under stirring.The solvent isopropanol was distilled off. Then add 660 kg of petroleum ether while stirring for 0.5 hour.The crystals are gradually cooled, and the stirring is intermittently started to prevent the product from being easily discharged from the bottom of the kettle after agglomeration. After the completion of the crystallization, the mixture was centrifuged and dried to give 184 kg of a white solid. The content of HPLC detection was 99.6%, and the hydrogenation reaction yield was 96.4%.The total yield of the two-step reaction was 79.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shanghai Jingwei Chemical Technology Co., Ltd.; Yao Husheng; Zhao Zhulin; Zhang Ming; Chen Bo; (6 pag.)CN108484484; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

17216-62-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17216-62-5, name is Diethyl 2-(2-cyanoethyl)malonate, A new synthetic method of this compound is introduced below.

EXAMPLE 9 1,4,8,11-Tetraaza-6-(2-cyanoethyl)-5,7-dioxoundecane, 8 Diethyl 2-(2-cyanoethyl)malonate 7 (5.0 g, 23.5 mmole–Aldrich Chemical Company) was added dropwise over a one hour period to a stirred portion of freshly distilled ethylene diamine (15 g, 0.25 mole) which was maintained under nitrogen at O C. The stirred solution was allowed to warm to room temperature (25 C.) and stirring was continued over a four day period. At this point, the excess ethylene diamine was removed in vacuo with care to avoid heating over 40 C. The crude clear oil which resulted was subjected to flash chromatography using Solvent System 3 as the eluent to give 2.3 g (8.81 mmole) of 1,4,8,11-tetraaza-6-(2-cyanoethyl)-5,7-dioxoundecane as a clear viscous oil in 37 percent yield (Rf =0.39/Solvent System 3): 1 H NMR (CDCl3) delta 7.59 (t, 2H, amide H), 3.29 (m, 5H, methine H and alpha-amido CH2), 2.82 (dt, 4H), beta-amido CH2) 2.48 (t, 2H, alpha-nitrile CH2) 2.21 (q, 2H, beta-nitrile CH2),1.39 (s, 4H, amino NH); 13 C NMR (CDCl3) delta 169.6 (amide carbonyl), 118.9 (nitrile), 52.9, 42.3, 41.2, 27.1, 15.4.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; The Dow Chemical Company; US5489425; (1996); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts