Category: 17201-43-3

Computed Properties of C8H6BrNIn 2019 ,《Self-assembly of a “”cationic-cage”” via the formation of Ag-carbene bonds followed by imine condensation》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Modak, Ritwik; Mondal, Bijnaneswar; Howlader, Prodip; Mukherjee, Partha Sarathi. The article contains the following contents:

A new strategy for the synthesis of a “”cationic-cage”” (CC-Ag) has been developed via metal-carbene (M-CNHC) bond formation followed by imine bond condensation. Reaction of a trigonal trisimidazolium salt H3L(PF6)3 functionalized with three flexible N-phenyl-aldehyde pendants with silver oxide yielded a trinuclear tricationic organometallic cage (OC-Ag). Subsequent treatment of the organometallic cage (OC-Ag) with 1,4-diaminobutane links the two tris-NHC ligands via imine bond condensation, which thus generates a 3D ‘cationic-cage’ (CC-Ag). Furthermore, post-synthetic replacement of the Ag(I) with Au(I) leading to the formation of CC-Au was achieved via trans-metalation, with the retention of the mol. architecture. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3Computed Properties of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Computed Properties of C8H6BrN

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Sethi, Navjot S.; Prasad, Deo N.; Singh, Rajesh K. published their research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021. The article was titled 《Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives》.Application of 17201-43-3 The article contains the following contents:

To develop novel compounds having potent anticancer and antibacterial activities. Several studies have proved that benzylidene analogs of clin. 2,4-TZDs, such as troglitazone and ciglitazone, have more potent antiproliferative activity than their parent compounds Literature studies also revealed that the attachment of more heterocyclic rings, containing nitrogen on 5th position of 2,4-TZD, can enhance the antimicrobial activity. Hence, attachment of various moieties on the benzylidene ring may produce safe and effective compounds in the future. The objective of the present study was to synthesize a set of novel benzylidene ring containing 5- and 3-substituted-2,4-thiazolidinedione derivatives and evaluate them for their anticancer and antibacterial activity. The synthesized compounds were characterized by IR, NMR, mass, and elemental studies. The in vitro cytotoxicity studies were performed for human breast cancer (MCF-7) and human lung cancer (A549) cells and HepG2 cell-line and compared to standard drug doxorubicin by MTT assay. Antimicrobial activity of the synthesized 2,4-thiazolidinediones derivatives was carried out using the cup plate method with slight modification. The results obtained showed that TZ-5 and TZ-13 exhibited good antiproliferative activity against A549 cancer cell-line, whereas TZ-10 exhibited moderate antiproliferative activity against HepG2 cell-line when compared to standard drug doxorubicin. TZ-5 also exhibited reasonable activity against the MCF-7 cell-line with doxorubicin as standard TZ-4, TZ-5, TZ-6, TZ-7, and TZ- 16 exhibited remarkable antibacterial activity against Gram pos. and moderate activity against Gram neg. bacteria with the standard drug ciprofloxacin. Attachment of heterocyclic rings containing nitrogen as the hetero atom improves the anticancer and antimicrobial potential. Attachment of electroneg. elements like halogens can also enhance the antimicrobial activity. Further structure modifications may lead to the development of more potent 2,4-TZD leads that can be evaluated for further advanced studies. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application of 17201-43-3

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Nitrile – Wikipedia,
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SDS of cas: 17201-43-3In 2019 ,《Modulating the expression of chirality in a mechanically chiral rotaxane》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Gell, Charles E.; McArdle-Ismaguilov, Timur A.; Evans, Nicholas H.. The article contains the following contents:

The expression of mech. chirality by a hydrogen bond templated rotaxane, as detected by 1H NMR spectroscopy, may be modulated by affecting the co-conformational behavior of the rotaxane through varying solvent or by addition of acid and base. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3SDS of cas: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.SDS of cas: 17201-43-3

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In 2022,Wu, Yong; Guo, Qing-Hui; Qiu, Yunyan; Weber, Jacob A.; Young, Ryan M.; Bancroft, Laura; Jiao, Yang; Chen, Hongliang; Song, Bo; Liu, Wenqi; Feng, Yuanning; Zhao, Xingang; Li, Xuesong; Zhang, Long; Chen, Xiao-Yang; Li, Hao; Wasielewski, Michael R.; Stoddart, J. Fraser published an article in Proceedings of the National Academy of Sciences of the United States of America. The title of the article was 《Syntheses of three-dimensional catenanes under kinetic control》.Synthetic Route of C8H6BrN The author mentioned the following in the article:

Although catenanes comprising two ring-shaped components can be made in large quantities by templation, the preparation of three-dimensional (3D) catenanes with cage-shaped components is still in its infancy. Here, the design and syntheses of two 3D catenanes by a sequence of SN2 reactions in one pot is reported. The resulting triply mech. interlocked mols. were fully characterized in both the solution and solid states. Mechanistic studies have revealed that a suit[3]ane, which contains a threefold sym. cage component as the suit and a tribromide component as the body, is formed at elevated temperatures This suit[3]ane was identified as the key reactive intermediate for the selective formation of the two 3D catenanes which do not represent thermodn. min. This particular synthetic strategy might be used in the future to guide the rational design and production of mech. interlocked mols. under kinetic control. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Synthetic Route of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Synthetic Route of C8H6BrN

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Nitrile – Wikipedia,
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Eldehna, Wagdy M.; Salem, Rofaida; Elsayed, Zainab M.; Al-Warhi, Tarfah; Knany, Hamada R.; Ayyad, Rezk R.; Traiki, Thamer Bin; Abdulla, Maha-Hamadien; Ahmad, Rehan; Abdel-Aziz, Hatem A.; El-Haggar, Radwan published their research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021. The article was titled 《Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer》.Application In Synthesis of 4-Cyanobenzyl bromide The article contains the following contents:

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates ( and ) was designed and synthesized. The anticancer activity for compounds (, and ) was measured against NCI-55 human cancer cell lines. Compound was the most efficient, and thus subjected to the five-dose screen where it showed excellent broad activity against almost all tested cancer subpanels. Furthermore, all conjugates ( and ) showed a good anti-proliferative activity towards colorectal cancer SW-620 and HT-29 cell lines, with an excellent inhibitory effect for compounds and (IC50 = 8.7 and 9.4μM (), and 6.5 and 9.8μM for (), resp.). Both compounds displayed selective cytotoxicity with good safety profile. In addition, both compounds provoked apoptosis in a dose dependent manner in SW-620 cells. Also, they significantly inhibited the anti-apoptotic Bcl2 protein expression and increased the cleaved PARP level that resulted in SW-620 cells apoptosis. After reading the article, we found that the author used 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application In Synthesis of 4-Cyanobenzyl bromide

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《De novo approach for the synthesis of water-soluble interlocked and non-interlocked organic cages》 was written by Chakraborty, Debsena; Modak, Ritwik; Howlader, Prodip; Mukherjee, Partha Sarathi. Related Products of 17201-43-3This research focused ontriazine immidazolium water metal free non interlocked organic cage. The article conveys some information:

Research on self-assembled metallosupramol. architectures has bloomed in recent times. Analogous metal-free organic architectures with water solubility are highly challenging. We report here a unique class of triazine based immidazolium water-soluble metal-free interlocked organic cage, which was synthesized in a one-pot reaction without using dynamic covalent chem. and without any chromatog. separation An analogous non-interlocked cage was also successfully achieved by steric control using different positional isomers of the building blocks. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Related Products of 17201-43-3

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Nitrile – Wikipedia,
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The author of 《Tuning of optical properties of p-phenyl ethenyl-E-furans: A Solvatochromism and Density functional theory》 were Kumar, Naresh; Paramasivam, Mahalingavelar; Kumar, Jagdeep; Gusain, Anamika; Hota, Prasanta Kumar. And the article was published in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2019. Recommanded Product: 4-Cyanobenzyl bromide The author mentioned the following in the article:

P-Ph ethenyl-E-furans (1-6) with varied electron donor and acceptor substituent (NO2, CN, Cl, H, OCH3, NH2) were synthesized and studied the substituent induced optical properties (dipole moment, transition dipole moment, oscillator strength, optical band gap, hyperpolarizability) using Solvatochromism and D. functional theory. It is shown that furan acts as a weak electron donor in presence of an electron withdrawing p-Ph substituent (NO2, CN, Cl), whereas furan acts as a weak electron acceptor in presence of an electron donating p-Ph substituent (OCH3, NH2). In comparison to ethenylfuran 4, the HOMO-LUMO energy band gap is decreased upon increasing the electron donating or electron withdrawing nature of the Ph ring. Calculation of excited state dipole moment and polarizability of 1-6 in solvent of varying polarity suggest that the nitro and amino compounds (1, 6) exhibit charge transfer excited state, whereas excited state of compounds 3-5 is non-polar in nature. As compared to the ethenylfuran (4), the first hyperpolarizability (β) is increased in presence of a strong electron withdrawing or strong electron donating p-Ph substituent. The higher β value is found for ethenylfuran with p-nitrophenyl and p-amino Ph substitution. Overall, these studies provide useful information in tuning the optical properties of p-Ph substituted heterocyclic ethenyl systems. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Recommanded Product: 4-Cyanobenzyl bromide

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The author of 《Targeted synthesis of ionic liquid-polyoxometalate derived Mo-based electrodes for advanced electrochemical performance》 were Chen, Guojian; Zhang, Lei; Zhang, Yadong; Liu, Ke; Long, Zhouyang; Wang, Ying. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. HPLC of Formula: 17201-43-3 The author mentioned the following in the article:

Rational design of advanced electrode materials with high capacity and long cycle stability is a great challenge for both Li and Na storage. The authors report a versatile strategy for the synthesis of N/P-codoped MoO2@carbon (N/P-MoO2@C) electrodes via a simple pyrolysis of ionic liquid-based polyoxometalate (IL-POM) mol. precursors. The contents of C, N, and P, and the pore geometry of N/P-MoO2@C networks can be easily tailored by adjusting the position of cyano groups in the IL-POM precursor. Benefiting from this novel design, the optimized N/P-MoO2@C4 electrode with cross-linked porous tunnels and abundant defects exhibits excellent Li storage performance, with a high reversible capacity of 1381 mA h g-1 after 100 cycles at 0.5 A-1, and 346 mA h g-1 after 5000 cycles at 20 A g-1. The Li+ storage performance of this N/P-MoO2@C4 is dominated by pseudocapacitance behavior, which contributed to the high reversible capacity and long cycle stability. Exceptional Na storage performance is also observed in the N/P-MoO2@C4 electrode with 0.02% capacity decay per cycle over 1100 cycles at 1.0 A g-1. The present approach provides some insight into the design and synthesis of task-specific Mo-based materials towards applications in energy storage and conversion. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.HPLC of Formula: 17201-43-3

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts