Category: 17201-43-3

Product Details of 17201-43-3In 2022 ,《Unveiling the impact of diverse morphology of ionic porous organic polymers with mechanistic insight on the ultrafast and selective removal of toxic pollutants from water》 appeared in ACS Applied Materials & Interfaces. The author of the article were Mandal, Writakshi; Fajal, Sahel; Mollick, Samraj; Shirolkar, Mandar M.; More, Yogeshwar D.; Saurabh, Satyam; Mahato, Debanjan; Ghosh, Sujit K.. The article conveys some information:

In recent years, detoxification of contaminated water by different types of materials has received a great deal of attention. However, lack of methodical in-depth understanding of the role of various phys. properties of such materials toward improved sorption performance limits their applicable efficiencies. In perspective, decontamination of oxoanion-polluted water by porous materials with different morphologies are unexplored due to a shortfall of proper synthetic strategies. Herein, systematic optimization of sequestration performance toward efficient decontamination of toxic oxoanion-polluted water has been demonstrated by varying the morphologies of an imidazolium-based cationic polymeric network [ionic porous organic polymers (iPOP-5)]. Detailed morphol. evolution showed that the chem. stable ionic polymer exhibited several morphologies such as spherical, nanotube, and flakes. Among them, the flakelike material [iPOP-5(F)] showed ultrafast capture efficiency (up to ~99 and >85% removal within less than 1 min) with high saturation capacities (301 and 610 mg g-1) toward chromate [Cr(VI)] and perrhenate [Re(VII)] oxoanions, resp., in water. On the other hand, the spherical-shaped polymer [iPOP-5(S)] exhibited relatively slow removal kinetics (>5 min for complete removal) toward both Cr(VI) and Re(VII) oxoanions. Notably, iPOP-5(F) eliminated Cr(VI) and Re(VII) selectively even in the presence of excessive (~100-fold) competing anions from both high- and low-concentration contaminated water. Further, the compound demonstrated efficient separation of those oxoanions in a wide pH range as well as in various water systems (such as potable, lake, river, sea, and tannery water) with superior regeneration ability. Moreover, as a proof of concept, a column exchange-based water treatment experiment by iPOP-5(F) has been performed to reduce the concentration of Cr(VI) and Re(VII) below the WHO permitted level. Mechanistic investigation suggested that the rare in situ exfoliation of flakes into thin nanosheets helps to achieve ultrafast capture efficiency. In addition, detailed theor. binding energy calculations were executed in order to understand such rapid, selective binding of chromate and perrhenate oxoanions with iPOP-5(F) over other nonmetal-based anions. After reading the article, we found that the author used 4-Cyanobenzyl bromide(cas: 17201-43-3Product Details of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Product Details of 17201-43-3

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Reference of 4-Cyanobenzyl bromideIn 2020 ,《Design, synthesis and biological evaluation of tetrahydroquinoline-based reversible LSD1 inhibitors》 was published in European Journal of Medicinal Chemistry. The article was written by Wang, Xinran; Zhang, Cai; Zhang, Xiangyu; Yan, Jiangkun; Wang, Jiming; Jiang, Qinwen; Zhao, Liyu; Zhao, Dongmei; Cheng, Maosheng. The article contains the following contents:

The targeted regulation of LSD1, which is highly expressed in a variety of tumor cells, is a promising cancer therapy strategy. Several LSD1 inhibitors are currently under clin. evaluation, and most of these inhibitors are irreversible. Here, the design, synthesis and biochem. evaluation of novel tetrahydroquinoline-based reversible LSD1 inhibitors has been reported. Compounds (I) and (II), which are selective to LSD1 over MAO-A/B, exhibit excellent LSD1 inhibition at the mol. levels with IC50= 55 nM and 540 nM, resp. The classic Lineweaver-Burk plots revealed that compound I could reversibly bind the LSD1 enzyme in a noncompetitive manner. Mol. docking was used to reveal the potential binding-mode of the compounds and interpret the structure-activity relationships. Furthermore, compounds I and II significantly inhibited proliferation (IC50= 1.13μM and 1.15μM, resp.) and induced apoptosis in MGC-803 cells with high expression of LSD1. Compound IIshowed acceptable liver microsomal stability. Meanwhile, II did not appear to inhibit CYPs at 10μM in vitro. Remarkably, the oral administration of compound II can inhibit the growth of MGC-803 xenograft tumors without significant side effects. Author findings suggest that tetrahydroquinoline-based LSD1 inhibitors deserve further investigation for the treatment of LSD1 overexpressing cancer. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Reference of 4-Cyanobenzyl bromide

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In 2019,Journal of the American Chemical Society included an article by Huang, David; Szewczyk, Suzanne M.; Zhang, Pengpeng; Newhouse, Timothy R.. COA of Formula: C8H6BrN. The article was titled 《Allyl-Nickel Catalysis Enables Carbonyl Dehydrogenation and Oxidative Cycloalkenylation of Ketones》. The information in the text is summarized as follows:

We herein disclose the first report of a first-row transition metal-catalyzed α,β-dehydrogenation of carbonyl compounds using allyl-nickel catalysis. This development overcomes several limitations of previously reported allyl-palladium-catalyzed oxidation, and is further leveraged for the development of an oxidative cycloalkenylation reaction that provides access to bicycloalkenones with fused, bridged, and spirocyclic ring systems using unactivated ketone and alkene precursors. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Journal of Asian Natural Products Research included an article by Zhang, Juan; Li, Jia-Cheng; Song, Jia-Li; Cheng, Zhi-Qiang; Sun, Ji-Zheng; Jiang, Cheng-Shi. COA of Formula: C8H6BrN. The article was titled 《Synthesis and evaluation of coumarin/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity》. The information in the text is summarized as follows:

A series of new coumarin/1,2,4-oxadiazole hybrids were synthesized and evaluated for cholinesterase inhibitory and neuroprotective activities. Among them, enantiomers and showed potent hBChE inhibitory activity with IC50 values of 8.17 and 9.56 μM, resp., and also exhibited good selectivity for hBChE over hAChE by 9.49- and 7.58-fold, resp. In addition, both compounds could protect SH-SY5Y cells against Aβ25-35-induced neurotoxicity. The preliminary bioassay results provided a new chemotype for multifunctional anti-Alzheimer′s disease agents and continuing investigation into compounds and is warranted. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Journal of Asian Natural Products Research included an article by Zhang, Juan; Li, Jia-Cheng; Song, Jia-Li; Cheng, Zhi-Qiang; Sun, Ji-Zheng; Jiang, Cheng-Shi. COA of Formula: C8H6BrN. The article was titled 《Synthesis and evaluation of coumarin/1,2,4-oxadiazole hybrids as selective BChE inhibitors with neuroprotective activity》. The information in the text is summarized as follows:

A series of new coumarin/1,2,4-oxadiazole hybrids were synthesized and evaluated for cholinesterase inhibitory and neuroprotective activities. Among them, enantiomers and showed potent hBChE inhibitory activity with IC50 values of 8.17 and 9.56 μM, resp., and also exhibited good selectivity for hBChE over hAChE by 9.49- and 7.58-fold, resp. In addition, both compounds could protect SH-SY5Y cells against Aβ25-35-induced neurotoxicity. The preliminary bioassay results provided a new chemotype for multifunctional anti-Alzheimer′s disease agents and continuing investigation into compounds and is warranted. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Kunj M. Trivedi; Patel, Unnati P.; Dabhi, Ranjit C.; Maru, Jayesh J. published an article in Russian Journal of Bioorganic Chemistry. The title of the article was 《Synthesis, Computational Insights and Anticancer Activity of Novel Indole-Schiff Base Derivatives》.Name: 4-Cyanobenzyl bromide The author mentioned the following in the article:

This paper described computational insights and synthesis of novel indole clubbed Schiff base derivatives I [R = Ph, 3-pyridyl, 4-MeC6H4, etc.] with improved biol. profile. The prepared derivatives I were evaluated for their in vitro anticancer activity against A549 cell line using MTT assay. Results revealed significant potential of the synthesized compounds, especially I [R = 2-furyl] which exhibited high anticancer activity. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Name: 4-Cyanobenzyl bromide

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 17201-43-3In 2021 ,《Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation》 appeared in European Journal of Medicinal Chemistry. The author of the article were Relitti, Nicola; Saraswati, A. Prasanth; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Herp, Daniel; Schmidtkunz, Karin; Saccoccia, Fulvio; Ruberti, Giovina; Ulivieri, Cristina; Vanni, Francesca; Sarno, Federica; Altucci, Lucia; Lamponi, Stefania; Jung, Manfred; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe. The article conveys some information:

The synthesis of potent and selective quinolone-based histone deacetylase 6 (HDAC6) inhibitors was reported. The quinolone moiety I and II [X= CH, N] was as an innovative bioactive cap-group for HDAC6 inhibition; its synthesis was achieved by applying a multicomponent reaction. The optimization of potency and selectivity of these products was performed by employing computational studies which leded to the discovery of the diethylaminomethyl derivatives II [X= CH, N] as the most promising hit mols. These compounds were investigated in cellular studies evaluated their anticancer effect against colon (HCT-116) and histiocytic lymphoma (U9347) cancer cells, showed good to excellent potency, leaded to tumor cell death by apoptosis induction. The small mols. I, II [X= CH, N] were able to strongly inhibit the cytoplasmic and slightly the nuclear HDAC enzymes, increased the acetylation of tubulin and of the lysine 9 and 14 of histone 3, resp. Compound II [X= CH] was also able to increase Hsp90 acetylation levels in HCT-116 cells, thus further supporting its HDAC6 inhibitory profile. Cytotoxicity and mutagenicity assays of these mols. showed a safe profile; moreover, the HPLC anal. of compound II [X= N] revealed good solubility and stability profile. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sathiyan, Govindasamy; Mathivanan, Dhamodiran; Bhuvaneshwari, Balasubramaniam; Garg, Ashish; Gupta, Raju Kumar; Singh, Anand published an article in 2021. The article was titled 《Olefin-linked conjugated fluorescent oligomer: Design, synthesis, photophysical studies and detection of nitroaromatic compounds (NACs) in aqueous media》, and you may find the article in Sensors and Actuators, A: Physical.Safety of 4-Cyanobenzyl bromide The information in the text is summarized as follows:

The development of novel fluorescent polymers has attracted significant attention owing to their potential applications in energy and environmental sciences. This study reports novel oligomer (TRZBT) synthesis via Wittig-Horner reaction using bithiophene aldehyde and triazine tri-Et phosphite. The resulting oligomer possesses large porous morphol., which was confirmed using SEM anal. Further, the chem. structure of TRZBT was confirmed by FT-IR, NMR, and GPC studies. The triazine acceptor (A) unit linked with bithiophene donor (D) unit through olefin π-conjugation resulted in a Donor-π-Acceptor (D-π-A) type oligomer. Detailed studies of the solvent-dependent photophys. properties of TRZBT were performed. Due to the alternate D-A structure of oligomer, enhanced intramol. charge transfer (ICT) properties between D and A moiety was observed Further, TRZBT in THF and THF: H2O (10:90) system effectively detected nitro-explosives in aqueous media, which exhibited high sensitivity, selectivity, and quick response via fluorescence quenching. TRZBT showed a higher quenching constant (Ksv) value of 4.91 x 105 M-1 towards picric acid as compared with other nitroaroms. Significantly, the detection limit of 1.58 nM in a 100% aqueous medium confirms that the synthesized material can detect even trace levels of the analyte. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Safety of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Safety of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dreas, Agnieszka; Kucwaj-Brysz, Katarzyna; Pyziak, Karolina; Kulesza, Urszula; Wincza, Ewelina; Fabritius, Charles-Henry; Michalik, Kinga; Gabor-Worwa, Ewelina; Golas, Aniela; Milik, Mariusz; Masiejczyk, Magdalena; Majewska, Eliza; Pysniak, Kazimiera; Wojcik-Trechcinska, Urszula; Sandowska-Markiewicz, Zuzanna; Brzozka, Krzysztof; Ostrowski, Jerzy; Rzymski, Tomasz; Mikula, Michal published an article in 2021. The article was titled 《Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock》, and you may find the article in European Journal of Medicinal Chemistry.Formula: C8H6BrN The information in the text is summarized as follows:

The mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNKs 1/2) and their downstream target eIF4E, play a role in oncogenic transformation, progression and metastasis. These results provided rationale for development of first MNKs inhibitors, currently in clin. trials for cancer treatment. Inhibitors of the MNKs/eIF4E pathway are also proposed as treatment strategy for inflammatory conditions. Here we present results of optimization of indazole-pyridinone derived MNK1/2 inhibitors among which compounds I and II, selective and metabolically stable derivatives Both compounds decreased levels of eIF4E Ser206 phosphorylation (pSer209-eIF4E) in MOLM16 cell line. When administered in mice compounds I and II significantly improved survival rates of animals in the endotoxin LD challenge model, with concomitant reduction of proinflammatory cytokine levels – TNFα and IL-6 in serum. Identified MNK1/2 inhibitors represent a novel class of immunomodulatory compounds with a potential for the treatment of inflammatory diseases including sepsis. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Formula: C8H6BrN

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitor and antitumor agent》 were Eldehna, Wagdy M.; Abo-Ashour, Mahmoud F.; Nocentini, Alessio; El-Haggar, Radwan S.; Bua, Silvia; Bonardi, Alessandro; Al-Rashood, Sara T.; Hassan, Ghada S.; Gratteri, Paola; Abdel-Aziz, Hatem A.; Supuran, Claudiu T.. And the article was published in European Journal of Medicinal Chemistry in 2019. Formula: C8H6BrN The author mentioned the following in the article:

Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids. A structural extension approach was adopted via N-alkylation and N-benzylation of isatin moiety to enhance the tail hydrophobic interactions within the carbonic anhydrase (CA) IX active site. Thereafter, a hybrid pharmacophore approach was utilized via merging the pharmacophoric elements of isatin and SLC-0111 in a single chem. framework. As planned, a substantial improvement of inhibitory profile of the target hybrids (KIs: 4.7-86.1 nM) towards hCA IX in comparison to N-unsubstituted leads (KIs: 192-239 nM), was achieved. Mol. docking of the designed hybrids in CA IX active site unveiled, as planned, the ability of N-alkylated and N-benzylated isatin moieties to accommodate in a wide hydrophobic pocket formed by T73, P75, P76, L91, L123 and A128, establishing strong van der Waals interactions. Hybrid I displayed good anti-proliferative activity under hypoxic conditions towards breast cancer MDA-MB-231 and MCF-7 cell lines (IC50 = 7.43 ± 0.28 and 12.90 ± 0.34 μM, resp.). Also, I disrupted the MDA-MB-231 cell cycle via alteration of the Sub-G1 phase and arrest of G2-M stage. Addnl., I displayed significant increase in the percent of annexinV-FITC pos. apoptotic cells from 1.03 to 18.54%. Furthermore, I displayed potent VEGFR-2 inhibitory activity (IC50 = 260.64 nM). Collectively, these data suggest I as a promising lead mol. for the development of effective anticancer agents. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts