Category: 17201-43-3

In 2019,Inorganica Chimica Acta included an article by Chang, Chao-Wan; Lee, Gene-Hsiang. Reference of 4-Cyanobenzyl bromide. The article was titled 《Synthesis of ruthenium triazolato complexes by the [3 + 2] cycloaddition of a ruthenium azido complex with acetylacetylenes》. The information in the text is summarized as follows:

The [3 + 2] cycloaddition of two acetylacetylenes with ruthenium azido complex [Ru]-N3 (1, [Ru] = (η5-C5H5)(dppe)Ru, dppe = Ph2PCH2CH2PPh2) is reported. The metal-bound heterocyclic complexes produced are triazolato complexes [Ru]N3C2H(COCH3) (2) and [Ru]N3C2(Ph)(COCH3) (3) from 3-butyn-2-one and 4-phenyl-3-butyn-2-one, resp. Both of the structures of 2 and 3 are clearly established as N(2)-bound. Alkylation of 2 with organic halides affords a series of N(1)-bound N(3)-alkyl-4-acetyl triazolato complexes {[Ru]N3(CH2R)C2H(COCH3)}[X] (4a, R = H, X = I; 4b, R = C6F5, X = Br; 4c, R = Ph, X = Br; 4d, R = 2,6-F2-C6H3, X = Br; 4e, R = 4-CN-C6H4, X = Br). Treatment of 4a with CH3I in refluxing CHCl3 afforded [Ru]-I (5). The structures of complexes 2, 3, 4a and 5 have been determined by single-crystal x-ray diffraction anal. The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Reference of 4-Cyanobenzyl bromide

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Category: nitriles-buliding-blocksIn 2019 ,《Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents》 was published in Bioorganic Chemistry. The article was written by Chavan, Pramod V.; Desai, Uday V.; Wadgaonkar, Prakash P.; Tapase, Savita R.; Kodam, Kisan M.; Choudhari, Amit; Sarkar, Dhiman. The article contains the following contents:

A series of spirochromenocarbazole tethered 1,2,3-triazoles I (R1 = H, Cl, Br, F, Me; R2 = Me, F, Br, etc.) were synthesized via click chem. based one-pot, five component reaction between N-propargyl isatins, malononitrile, 4-hydroxycarbazole, aralkyl halides and sodium azide using cellulose supported CuI nanoparticles (Cell-CuI NPs) as the heterogeneous catalyst. Antiproliferative activity of all the synthesized compounds was investigated against panel of cancer cell lines such as MCF-7, MDA-MB-231, HeLa, PANC-1, A-549, and THP-1. Many of the synthesized compounds exhibited good anti-proliferative activity against breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cells with IC50 values less than 10 μM. In case of MCF-7 cells, among the nine compounds that showed good anti-proliferative activity, compound I (R1 = H; R2 = NO2) was found to be highly potent (IC50 = 2.13 μM). On the other hand, in cervical cancer HeLa cells, compounds I (R1 = H, Br; R2 = Me, CF3, Cl) showed excellent antiproliferative activity (IC50 = 4.05, 3.54, 3.83, 3.35 μM, resp.). All the compounds were found to be nontoxic to the human umbilical vein endothelial cells (HUVECs). AO and EtBr staining and fluorescence microscopy studies of the active compounds (IC50 < 5 μM) suggested that these compounds induce cell death by apoptosis. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Category: nitriles-buliding-blocks)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Category: nitriles-buliding-blocks

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《Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region》 was published in Bioorganic Chemistry in 2020. These research results belong to Floresta, Giuseppe; Fallica, Antonino N.; Romeo, Giuseppe; Sorrenti, Valeria; Salerno, Loredana; Rescifina, Antonio; Pittala, Valeria. HPLC of Formula: 17201-43-3 The article mentions the following:

The enzymic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chem. modulators and the greater attentiveness towards HO-1 isoform. In the present paper, we report the rational design and synthesis of HO-2 inhibitors achieved by modulating the volume of known HO-1 inhibitors. The inhibition preference has been moved from HO-1 to HO-2 by merely increasing the volume of the substituent in the western region of the inhibitors. Docking studies demonstrated that new derivatives soak differently in the two binding pockets, probably due to the presence of a Tyr187 residue in HO-2. These findings could be useful for the design of new selective HO-2 compounds The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.HPLC of Formula: 17201-43-3

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Reference of 4-Cyanobenzyl bromideIn 2022 ,《Photocatalytic activity of ultrathin 2DPNs for enzymatically generating formic acid from CO2 and C-S/C-N bond formation》 appeared in Sustainable Energy & Fuels. The author of the article were Singh, Pooja; Yadav, Rajesh K.; Singh, Chandani; Chaubey, Surabhi; Singh, Satyam; Singh, Atul P.; Baeg, Jin-OoK.; Kim, Tae Wu; Gulzhian, Dzhardimalieva. The article conveys some information:

The exploration of efficient and cheap photocatalysts for the transformation of CO2 into value-added chems. is a cornerstone challenge in organic chem. Two-dimensional covalent organic frameworks (2D-COFs) have attracted a great deal of increasing demand in the field of photocatalysis. Here, we report the design and development of two-dimensional porphyrin nanoplates (2DPNs) as low-cost and highly efficient photocatalysts. The construction of 2DPNs was achieved by the reaction of 5,10,15,20-tetraphenylporphyrin (TPP) building block units via a one-pot Friedel-Crafts reaction. The study revealed that the resultant photocatalyst has many useful properties of a better catalyst such as the superb solar light-harvesting ability, suitability of the optical band-gap, and highly ordered π-electron channels facilitating efficient charge migrations. Further study provides the better utility of 2DPN photocatalysts in the generation of solar fine chems. via the formation of C-S and C-N bonds under solar light irradiation with excellent reusability property. Furthermore, the 2DPN photocatalysts have been efficiently used as catalysts in the CO2 fixation and generation of formic acid as a green energy source under metal-free conditions. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Reference of 4-Cyanobenzyl bromide

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《Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins》 was published in Future Medicinal Chemistry in 2020. These research results belong to Yao, Chun-Hsu; Hsieh, Tsung-Chih; Song, Jen-Shin; Lee, Jinq-Chyi. Electric Literature of C8H6BrN The article mentions the following:

Cancer is a major health burden and a leading cause of death worldwide. We sought to discover potential anticancer mols. with novel scaffold for further development of more active agents to address the issue. A series of β-carboline-1-one hydantoins were designed according to a conformational restriction strategy, synthesized via a one-pot Knoevenagel condensation-intramol. cyclization, and tested in cytotoxicity assays. The study culminated in the identification of 6b and 6c, both of which were found to potently inhibit breast and lung cancer cell lines. Of particular interest was 6c, which was 83 times more potent an inhibitor than 5-fluorouracil in inhibiting MCF-7. This work establishes β-carboline-1-one hydantoin as a promising scaffold in the investigation of anticancer agents. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN

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In 2019,Journal of Medicinal Chemistry included an article by Guo, Zuhao; Zhang, Zhuqing; Yang, Hong; Cao, Danyan; Xu, Xiaowei; Zheng, Xingling; Chen, Danqi; Wang, Qi; Li, Yanlian; Li, Jian; Du, Zhiyan; Wang, Xin; Chen, Lin; Ding, Jian; Shen, Jingkang; Geng, Meiyu; Huang, Xun; Xiong, Bing. Application In Synthesis of 4-Cyanobenzyl bromide. The article was titled 《Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia》. The information in the text is summarized as follows:

PRMT4 is a type I protein arginine methyltransferase and plays important roles in various cellular processes. Overexpression of PRMT4 has been found to be involved in several types of cancers. Selective and in vivo effective PRMT4 inhibitors are needed for demonstrating PRMT4 as a promising therapeutic target. On the basis of compound I, a weak dual PRMT4/6 inhibitor, several tetrahydroisoquinolines has been constructed through a cut-and-sew scaffold hopping strategy. The subsequent SAR optimization efforts employed structure-based approach led to the identification of a novel PRMT4 inhibitor II. Compound 49 exhibited prominently high potency and selectivity, moderate pharmacokinetic profiles, and good antitumor efficacy in acute myeloid leukemia xenograft model via oral administration, thus demonstrating this compound as a useful pharmacol. tool for further target validation and drug development in cancer therapy. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application In Synthesis of 4-Cyanobenzyl bromide

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Yuan, Shuo; Wang, Bo; Dai, Qing-Qing; Zhang, Xiao-Nan; Zhang, Jing-Ya; Zuo, Jia-Hui; Liu, Hui; Chen, Zhe-Sheng; Li, Guo-Bo; Wang, Shaomeng; Liu, Hong-Min; Yu, Bin published an article in 2021. The article was titled 《Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors》, and you may find the article in Journal of Medicinal Chemistry.Reference of 4-Cyanobenzyl bromide The information in the text is summarized as follows:

The major drawbacks of P-glycoprotein (P-gp) inhibitors at the clin. stage make the development of new P-gp inhibitors challenging and desirable. In this study, we reported our structure-activity relationship studies of 4-indolyl quinazoline, which led to the discovery of a highly effective and orally active P-gp inhibitor, YS-370. YS-370 effectively reversed multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 bound directly to P-gp, did not alter expression or subcellular localization of P-gp in SW620/AD300 cells, but increased the intracellular accumulation of paclitaxel. Furthermore, YS-370 stimulated the P-gp ATPase activity and had moderate inhibition against CYP3A4. Significantly, oral administration of YS-370 in combination with paclitaxel achieved much stronger antitumor activity in a xenograft model bearing SW620/Ad300 cells than either drug alone. Taken together, our data demonstrate that YS-370 is a promising P-gp inhibitor capable of overcoming MDR and represents a unique scaffold for the development of new P-gp inhibitors. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Reference of 4-Cyanobenzyl bromide

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Nitrile – Wikipedia,
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Chen, Yuhang; Li, Pan; Yuan, Caili; Zeng, Lingping; Wang, Jianchuan; Li, Baosheng; Wei, Zidong published an article in 2022. The article was titled 《Anion Exchange Membranes Synthesized by Acetalization of Poly(vinyl alcohol) for Fuel Cells》, and you may find the article in ACS Applied Energy Materials.Application In Synthesis of 4-Cyanobenzyl bromide The information in the text is summarized as follows:

High-performance anion exchange membranes (AEMs) are the bottleneck of the commercialization of alk. AEM fuel cells. Various methods have been developed to prepare AEMs with high ionic conductivity, excellent mech. properties, and alk. stability. Among them, modification of various com. polymers is a facile and effective way. To broaden the category of the com. polymer-based AEMs, herein, a series of AEMs based on poly(vinyl alc.) were prepared by acetalization. The PVA-FBMPx-TPAz membrane achieved OH- conductivity up to 200.4 mS cm-1 at 80°C with appropriate water uptake and a low swelling ratio. Moreover, a high peak power d. of 982 mW cm-2 was obtained in a H2/O2 fuel cell test. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Application In Synthesis of 4-Cyanobenzyl bromide

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Name: 4-Cyanobenzyl bromideIn 2019 ,《Catalyst-Free Sulfonylation of (Hetero)aryl Iodides with Sodium Dithionite》 was published in Advanced Synthesis & Catalysis. The article was written by Li, Yuewen; Liu, Tong; Qiu, Guanyinsheng; Wu, Jie. The article contains the following contents:

The com. available and cheap sodium dithionite was used as the source of sulfonyl group for the synthesis of heteroaryl-sulfones I [R = n-Pr, Ph, 4-MeC6H4, etc.; R1 = 2-thienyl, 2-pyridyl, 2-pyrimidinyl, etc.] and sulfonamides II [R2 = Et, Ph; R3 = Me, Et; R2R3 = (CH2)4, (CH2)2O(CH2)2, (CH2)2S(CH2)2] from heteroaryl-iodides under catalyst-free conditions. During the reaction process, sodium sulfinates generated in situ were the key intermediate, which further converted into heteroaryl-sulfones I and sulfonamides II by treating with bromoalkanes and amines resp. This transformation proceeded through a radical process initiated by sodium dithionite, providing a convenient route to sulfonyl-containing compounds The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Name: 4-Cyanobenzyl bromide

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In 2019,Bioorganic Chemistry included an article by Narella, Sridhar Goud; Shaik, Mohammed Ghouse; Mohammed, Arifuddin; Alvala, Mallika; Angeli, Andrea; Supuran, Claudiu T.. Formula: C8H6BrN. The article was titled 《Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors》. The information in the text is summarized as follows:

With an aim to develop novel heterocyclic hybrids as potent anticancer agents, we synthesized a series of coumarin-1,3,4-oxadiazole hybrids (7a-t) and evaluated for their inhibitory activity against the four physiol. relevant human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms CA I, CA II, CA IX and CA XII. The CA inhibition results clearly indicated that the coumarin-1,3,4-oxadiazole derivatives (7a-t) exhibited selective inhibition of the tumor associated isoforms, CA IX and CA XII over CA I and II isoforms. Among all, compound 7b, exhibited significant inhibition in lower micromolar potency against hCA XII, with a Ki of 0.16 μM and compound 7n, exhibited significant inhibition in lower micromolar potency against hCA IX, with a Ki of 2.34 μM resp. Therefore, compound 7b and 7n could be the potential leads for development of selective anticancer agents by exhibiting a novel mechanism of action through hCA IX and XII inhibition. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts