Category: 17201-43-3

In 2019,Chemical Science included an article by Song, Hualong; Rogers, Nicola J.; Allison, Simon J.; Brabec, Viktor; Bridgewater, Hannah; Kostrhunova, Hana; Markova, Lenka; Phillips, Roger M.; Pinder, Emma C.; Shepherd, Samantha L.; Young, Lawrence S.; Zajac, Juraj; Scott, Peter. Electric Literature of C8H6BrN. The article was titled 《Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification》. The information in the text is summarized as follows:

Helicates and related metallofoldamers, synthesized by dynamic self-assembly, represent an area of chem. space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-soluble, optically pure Fe(II)- and even Zn(II)-based triplex metallohelices are an excellent platform for post-assembly click reactions. By these means, the in vitro anticancer activity and most importantly the selectivity of a triplex metallohelix Fe(II) system are dramatically improved. For one compound, a remarkable array of mechanistic and pharmacol. behaviors is discovered: inhibition of Na+/K+ ATPase with potency comparable to the drug ouabain, antimetastatic properties (including inhibition of cell migration, re-adhesion and invasion), cancer stem cell targeting, and finally colonosphere inhibition competitive with the drug salinomycin. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dang, Xin; Lei, Shuwen; Luo, Shuhua; Hu, Yixin; Wang, Juntao; Zhang, Dongdong; Lu, Dan; Jiang, Faqin; Fu, Lei published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells》, and you may find the article in Bioorganic Chemistry.COA of Formula: C8H6BrN The information in the text is summarized as follows:

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3COA of Formula: C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.COA of Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Design and Synthesis of 5-Morpholino-Thiophene-Indole/Oxindole Hybrids as Cytotoxic Agents》 was written by Yadav, Upasana; Sakla, Akash P.; Tokala, Ramya; Nyalam, Sai Teja; Khurana, Amit; Digwal, Chander Singh; Talla, Venu; Godugu, Chandraiah; Shankaraiah, Nagula; Kamal, Ahmed. Application of 17201-43-3 And the article was included in ChemistrySelect in 2020. The article conveys some information:

A series of new 5-morpholino-thiophene-indole/oxindole hybrids (Z)-I (R1 = PhCH2, 4-MeOC6H4CH2, 4-NCC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 4-ClC6H4CH2; R2 = 4-MeOC6H4, 4-MeC6H4, 4-ClC6H4) and (Z)-II (R3 = H, Cl) has been designed and synthesized using mol. hybridization approach. The synthesized compounds I and II were evaluated for their in vitro cytotoxic potential against selected human cancer cell lines such as triple neg. breast (MDA-MB-231), liver (SK-Hep-1), breast (MCF-7), colon (HCT-116) mouse melanoma (B16F10) and compared with normal human lung epithelial cell line (BEAS-2B). Among I and II, I (R1 = PhCH2; R2 = 4-MeC6H4) (III) showed significant cytotoxicity in HCT-116 cancer cells with an IC50 value of 8.98 ± 0.6μM. Cell cycle anal. revealed that selected compounds arrested the cell cycle in sub-G1 phase. Moreover, JC-1, acridine orange, DAPI nucleic acid, and DCFDA staining studies suggest that III inhibited cellular proliferation through induction of apoptosis. Further, mol. docking and relative viscosity studies of III indicated that III bound in the minor groove of calf thymus DNA. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Application of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Application of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Wenling; Guan, Xinqiao; Huang, Bingcheng; Ye, Qiuhao; Zhang, Tiantian; Chen, Kuizhi; Peng, Yiru; Fu, Fangmeng published an article in 2021. The article was titled 《Fluorinated dendritic silicon (IV) phthalocyanines nanoparticles: Synthesis, photoinduced intramolecular energy transfer and DNA interaction》, and you may find the article in Dyes and Pigments.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

Two series of fluorinated and non-fluorinated dendritic silicon (IV) phthalocyanines with cyano/nitro/ester terminal functionalities have been synthesized. Their structures were characterized by elemental anal., FT-IR, 1H NMR and ESI-MS. The effects of fluorinated groups and terminal functionalities properties on the photophys. properties, photoinduced intermol. electron transfer and intramol. energy transfer of silicon phthalocyanines were compared. In order to endow water soluble and biocompatibility to these silicon phthalocyanines, an amphiphilic diblock copolymer polyethylene glycol monomethyl ether-polycaprolactone was used to encapsulate these silicon phthalocyanines to form fluorinated and non-fluorinated dendritic silicon phthalocyanines nanoparticles. The binding model between the fluorinated dendritic silicon phthalocyanines nanoparticles and calf thymus DNA was studied by UV-Vis and fluorescence spectroscopic method. The photocleavage DNA activities of three fluorinated dendritic silicon phthalocyanines nanoparticles were compared and the possible cleavage mechanism was proposed. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Category: nitriles-buliding-blocks) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Thermochromic aggregation-induced dual phosphorescence via temperature-dependent sp3-linked donor-acceptor electronic coupling》 was written by Wang, Tao; Hu, Zhubin; Nie, Xiancheng; Huang, Linkun; Hui, Miao; Sun, Xiang; Zhang, Guoqing. Application In Synthesis of 4-Cyanobenzyl bromideThis research focused ontriphenylamine phosphorescence aggregation induced emission. The article conveys some information:

Aggregation-induced emission (AIE) has proven to be a viable strategy to achieve highly efficient room temperature phosphorescence (RTP) in bulk by restricting mol. motions. Here, we show that by utilizing triphenylamine (TPA) as an electronic donor that connects to an acceptor via an sp3 linker, six TPA-based AIE-active RTP luminophores were obtained. Distinct dual phosphorescence bands emitting from largely localized donor and acceptor triplet emitting states could be recorded at lowered temperatures; at room temperature, only a merged RTP band is present. Theor. investigations reveal that the two temperature-dependent phosphorescence bands both originate from local/global min. from the lowest triplet excited state (T1). The reported mol. construct serves as an intermediary case between a fully conjugated donor-acceptor system and a donor/acceptor binary mix, which may provide important clues on the design and control of high-freedom mol. systems with complex excited-state dynamics. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Application In Synthesis of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Chen, Xinhui; Yang, Fan; Han, Congcong; Han, Licong; Wang, Fubo; Jin, Guoxia; Wang, Haiying; Ma, Jianping published an article in Inorganic Chemistry. The title of the article was 《[Fe2S2-Agx]-Hydrogenase Active-Site-Containing Coordination Polymers and Their Photocatalytic H2 Evolution Reaction Properties》.Quality Control of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Three [Fe2S2-Agx]-hydrogenase active-site-containing coordination polymers (CPs), {[Fe2S2-Ag1](4-cpmt)2(CO)6(ClO4-)}n (1), {[Fe2S2-Ag2](4-cpmt)2(CO)6(OTf-)2(benzene)}n (2), and {[Fe2S2-Ag2](3-cpmt)2(CO)6(ClO4-)2}n (3), were obtained by a direct synthesis method from ligands [FeFe](4-cpmt)2(CO)6 [L1; 4-cpmt = (4-cyanophenyl)methanethiolate] and [FeFe](3-cpmt)2(CO)6 [L2; 3-cpmt = (3-cyanophenyl)methanethiolate] with silver salts. 1-3 Represent the first examples of [FeFe]-hydrogenase-based CPs. It was worth noting that the Ag-S bonding between the Ag centers and S atoms of a [Fe2S2] cluster produced a novel [Fe2S2-Agx] (x = 1 or 2) catalytic site in all three polymers. The results of photochem. H2 generation experiments indicated that 2 and 3 containing [Fe2S2-Ag2] active sites showed obviously improved catalytic performances compared with ligands L1 and L2 and [Fe2S2-Ag1]-containing 1. This work provides a pioneering strategy for the direct synthesis of [Fe2S2]-based CPs or metal-organic frameworks. The experimental process involved the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Quality Control of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Quality Control of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bommera, Ravi Kumar; Kethireddy, Shashikala; Govindapur, Rajeshwar Reddy; Eppakayala, Laxminarayana published an article in 2021. The article was titled 《Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents》, and you may find the article in BMC Chemistry.Recommanded Product: 4-Cyanobenzyl bromide The information in the text is summarized as follows:

A 1,2,4-oxadiazole derivatives exhibited significant anti-cancer activity when they were evaluated, against human cancer cell lines. They also showed anti-inflammatory, analgesic, diabetic, immunosuppressive, α,β3-receptor antagonist, antimicrobial, anti-helminthic, histamine-H3 and antiparasitic properties. A pyrimidine analog, 5 fluoro-uracil is a chemotherapeutic drug used for treating multiple solid malignant tumors. But its application is limited, as it has side effects like low bioavailability and high toxicity. Mol. docking is an exemplary tool, helps in identifying target and designing a drug containing high bio-availability and min. toxicity. A set of 1,2,4-oxadiazole linked 5-fluoruracil derivatives (7a-j) were synthesized and their structures were confirmed by 1HNMR, 13CNMR and Mass spectral anal. Further, these compounds were investigated for their anticancer activity towards a panel of four human cancer cell lines such as (MCF-7, MDA MB-231), lung cancer (A549) and prostate cancer (DU-145) by using MTT method. Among them, compounds 7a, 7b, 7c, 7d and 7i demonstrated more promising anticancer activity than standard Synthesized derivatives (7a-j) of 1,2,4-oxadiazole linked 5-fluorouracil and investigated for their anticancer activity towards a panel of four human cancer cell lines. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Recommanded Product: 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jin, Xin; Yang, Tingting; Xia, Chenlu; Wang, Nina; Liu, Zi; Cao, Jianguo; Ma, Liang; Huang, Guozheng published an article in 2022. The article was titled 《Design and synthesis of alepterolic acid and 5-fluorouracil conjugates as potential anticancer agents》, and you may find the article in Mendeleev Communications.Related Products of 17201-43-3 The information in the text is summarized as follows:

Conjugates of alepterolic acid with 5-fluorouracil derivatives I (Ar = Ph, 2,4-dichlorophenyl, 1-naphthyl, etc.) have been synthesized in 70-90% yields. The cytotoxic evaluation against two human cancer cell lines, viz. MCF-7 (breast) and A549 (lung), using MTT assay showed anticancer activities of the obtained compounds The results came from multiple reactions, including the reaction of 4-Cyanobenzyl bromide(cas: 17201-43-3Related Products of 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Related Products of 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Current Organic Synthesis included an article by Gao, Hui; Liu, Bei; Zhu, Ping; Zhang, Li-Jun; Wan, Chun-Ping; Rao, Gao-Xiong; Mao, Ze-Wei. Electric Literature of C8H6BrN. The article was titled 《Synthesis and Biological Evaluation of New Piperazine Substituted 3, 5-Diarylisoxazolines》. The information in the text is summarized as follows:

A series of new piperazine substituted 3,5-diphenylisoxazoline derivatives I [R = H, H3CCO, 4-O2NC6H4, etc.] were designed and synthesized and in-vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW-264.7 macrophages and anticancer effect against a panel of human tumor cell lines (Hela, A549 and SGC7901) by MTT assay were evaluated. Structure-activity relationship of the synthesized compounds I was conducted and concluded that the substituents of the NH group of piperazine ring had an obvious influence on biol. activities. Especially, compounds I [R = H, ClCH2CO, ClCH2CH2CO, 4-F3CC6H4CO, 3,5-ClC6H3CO, C6H5CHCHCO, 4-BrC6H4COCH2] showed good inhibitory effect on the generation of NO compared to dexamethasone. Furthermore, derivatives I [R = H, H3CCO, ClCH2CO, ClCH2CH2CO, H3COCOCH2CO, C6H5CHCHCO, 4-ClC6H4COCH2] were found to be potential selectively anticancer activity on human tumor cell lines, which displayed better cytotoxic activity to pos. control 5-FU. Piperazine substituted 3, 5-diarylisoxazoline derivatives could be considered as new antiinflammatory and anticancer agents. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Synlett included an article by Asquith, Christopher R. M.; Konstantinova, Lidia S.; Tizzard, Graham J.; Laitinen, Tuomo; Coles, Simon J.; Rakitin, Oleg A.; Hilton, Stephen T.. HPLC of Formula: 17201-43-3. The article was titled 《Exploration and Development of a C-H-Activated Route to Access the [1,2]Dithiolo[4,3-b]indole-3(4H)-thione Core and Related Derivatives》. The information in the text is summarized as follows:

N-Substituted 2-methylindoles I [R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3] underwent chemoselective oxidative cyclocondensation reactions with the DABCO complex of S2Cl2 (generated in situ from S2Cl2 and DABCO) in CHCl3 followed by Et3N to yield dithioloindolethiones II [R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3]. I (R = H, F; R1 = Me, Et, i-Pr, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2) were prepared by N-alkylation of 2-methylindoles with alkyl bromides using either KOH in DMF or NaH and NaI in THF. The structures of I [R = H, F; R1 = Me, i-Bu, 2-FC6H4CH2, 3-FC6H4CH2, 4-FC6H4CH2, 3,4-F2C6H3CH2, PhCH2CH2CH2, 2-NCC6H4CH2, 3-NCC6H4CH2, 4-NCC6H4CH2, PhCH2, 2-MeOC6H4CH2, 3-MeOC6H4CH2, 3,4-(MeO)2C6H3, 3-F-4-MeOC6H3] were determined by X-ray crystallog. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3HPLC of Formula: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.HPLC of Formula: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts