Category: 17201-43-3

In 2019,Polyhedron included an article by Kumar, Atul; Zangrando, Ennio; Mukherjee, Partha Sarathi. Quality Control of 4-Cyanobenzyl bromide. The article was titled 《Self-assembled Pd3L2 cages having flexible tri-imidazole donors》. The information in the text is summarized as follows:

Four new M3L2 mol. cages (CA1-CA4) were synthesized in excellent yield via coordination driven self -assembly of flexible tri-imidazole donors based on imidazolylphenyltriazine (L1) and imidazolylphenylbenzene (L2) cores with 90° cis-blocked (tetramethylethylenediamine or bis(diphenylphosphino)ferrocene) metal acceptors of Pd(II). Two of them CA1 and CA2 are highly soluble in H2O. All the cages were characterized by spectroscopic studies and ESI-MS; CA3 and CA4 also by x-ray diffraction. Selective formation of cages CA3 and CA4 was noticed instead of a hetero-ligand cage, when the metal acceptor (dppf)Pd(OTf)2 was treated with a mixture of ligands L1 and L2.4-Cyanobenzyl bromide(cas: 17201-43-3Quality Control of 4-Cyanobenzyl bromide) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Quality Control of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Kaya, Meltem; Demir, Sevde; Arici, Mursel; Wriedt, Mario; Yesilel, Okan Zafer published an article in Polyhedron. The title of the article was 《Synthesis, characterization, and optical properties of four coordination polymers with 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide》.Safety of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Four coordination polymers based on a new 3,5-dicarboxy-1-(4-cyanobenzyl)pyridin-1-ium bromide (H2cbpyBr), formulated as {[Mn(μ-cbpy)2]·2H2O}n (1), {[Co(μ-cbpy)2]·2H2O}n (2), {[Cu(μ-cbpy)2]·H2O}n (3) and {[Zn3(μ-cbpy)6]·6H2O}n (4) were synthesized and characterized by x-ray single-crystal, IR spectroscopy, powder diffraction, and elemental anal. X-ray diffraction anal. revealed that isostructural complexes 1, 2, and 4 displayed 1D structures while complex 3 exhibited 3D coordination polymer with 66-dia topol. In complexes 1, 2, and 4, the adjacent 1D chains were further assembled by π···π and C:N, π interactions into the 3D supramol. framework. Furthermore, optical properties for the compounds were calculated and thermal behaviors of all the complexes were studied at 30-1000°. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Safety of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is a white solid. Its melting point is 113-117°C, and flash point is 125.1°C. It is insoluble in water at 20°C. It is stable under normal temperatures and pressures. It should be stored at 0-5°C.Safety of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Yinan; Chen, Hui; Sheng, Ruilong; Fu, Zhe; Fan, Junting; Wu, Wenhui; Tu, Qidong; Guo, Ruihua published an article in 2021. The article was titled 《Synthesis and bioactivities of marine pyran-isoindolone derivatives as potential antithrombotic agents》, and you may find the article in Marine Drugs.Name: 4-Cyanobenzyl bromide The information in the text is summarized as follows:

2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-teraahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran-isoindolone derivative isolated from a rare marine microorganism Stachybotrys longispora FG216, which showed moderate antithrombotic (fibrinolytic) activity. To further enhance its antithrombotic effect, a series of new FGFC1 derivatives I (R = CH3, Et, Pr, etc.) were synthesized via chem. modification at C-2 and C-2″” phenol groups moieties and C-1″” carboxyl group. Their fibrinolytic activities in vitro were evaluated. Among the derivatives, I (R = CH3, Et, Pr, 4-CNC6H4CH2 and 4-BrC6H4CH2) showed significant fibrinolytic activities with EC50 of 59.7, 87.1, 66.6, 82.8, and 42.3μM, resp., via enhancement of urokinase activity. Notably, derivative I (R = 4-BrC6H4CH2) presented the most remarkable fibrinolytic activity (2.72-fold than that of FGFC1). Furthermore, the cytotoxicity of derivative I (R = 4-BrC6H4CH2) was tested as well as expression of Fas/Apo-1 and IL-1 on HeLa cells. The results showed that, compared to FGFC1, derivative I (R = 4-BrC6H4CH2) possessed moderate cytotoxicity and apoptotic effect on HeLa cells (statistical significance p > 0.1), making (R = 4-BrC6H4CH2) a potential antithrombotic agent towards clin. application. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanobenzyl bromide(cas: 17201-43-3Name: 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Name: 4-Cyanobenzyl bromide

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Nitrile – Wikipedia,
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《Catalytic Conversion of N-Heteroaromatics to Functionalized Arylamines by Merging Hydrogen Transfer and Selective Coupling》 was published in ACS Catalysis in 2020. These research results belong to Tan, Zhenda; Ci, Chenggang; Yang, Jian; Wu, Yang; Cao, Liang; Jiang, Huanfeng; Zhang, Min. Safety of 4-Cyanobenzyl bromide The article mentions the following:

A ruthenium-catalyzed deconstruction of N-heteroaromatics to functionalized arylamines with 2-aminoaryl methanols via hydrogen transfer and selective coupling was reported. The reaction was achieved via sequential functionalization of the β and α-sites of the initially formed N-heteroarenium salts followed by a C-N cleavage, proceeding with the striking features of broad substrate scope, excellent functional groups tolerance, high chemoselectivity and atom-efficiency, and applicable for streamline synthesis of some biomedical mols. The strategy utilized will pave the avenues for further development of catalytic transformations of inert organo-systems to functional frameworks. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Safety of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Safety of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pan, Ming; Shao, Ying-Bo; Zhao, Qun; Li, Xin published an article in 2022. The article was titled 《Asymmetric Synthesis of N-N Axially Chiral Compounds by Phase-Transfer-Catalyzed Alkylations》, and you may find the article in Organic Letters.Reference of 4-Cyanobenzyl bromide The information in the text is summarized as follows:

A wide range of N-N axially chiral quinazolinone derivatives I (R1 = Ph, prop-1-en-2-yl, 3-chlorphenyl, etc.; R2 = Ph, 1-naphthyl, prop-1-ynyl, etc.; R3 = Ph, t-Bu, 3-bromophenyl, etc.; R4 = H, 7-Me, 6-I, 5-Cl, etc.) were prepared by phase-transfer catalysis in high yields with excellent stereoselectivities. Furthermore, the synthetic utility of the protocol was proved by large-scale reaction and transformation of the product. D. functional theory calculations provide insight into the mechanism. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Reference of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Reference of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Visible-Light-Induced Dehydrohalogenative Coupling for Intramolecular α-Alkenylation: A Way to Build Seven- and Eight-Membered Rings》 was written by Xu, Dawen; Li, Han; Pan, Guangxing; Huang, Pan; Oberkofler, Jens; Reich, Robert M.; Kuhn, Fritz E.; Guo, Hao. Quality Control of 4-Cyanobenzyl bromideThis research focused onvisible light dehydrohalogenative coupling photocycloaddition diene. The article conveys some information:

A visible-light-induced intramol. α-alkenylation has been developed via metal-free dehydrohalogenative C(sp2)-C(sp2) coupling reaction to afford seven- and eight-membered rings. Extensive mechanistic studies prove that this reaction proceeds through a [2+2]-photocycloaddition, elimination, and retro-[2+2]-photocycloaddition process, with cyclobutane and cyclobutene being involved as key intermediates. This transformation is broadly applicable and highly stereoselective, yielding exclusively cyclic (1Z,3Z)-1,3-diene via photochem. allowed disrotation. This protocol excavates new applications of [2 + 2]-photocycloadditions, which may find their way in future olefin-olefin coupling reactions and medium-sized ring synthesis. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Quality Control of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Quality Control of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Design, synthesis and biological evaluation of pentacyclic triterpene derivatives: optimization of anti-ABL kinase activity》 were Ciftci, Halil I.; Radwan, Mohamed O.; Ozturk, Safiye E.; Ulusoy, N. Gokce; Sozer, Ece; Ellakwa, Doha E.; Ocak, Zeynep; Can, Mustafa; Ali, Taha F. S.; Abd-Alla, Howaida I.; Yayli, Nurettin; Tateishi, Hiroshi; Otsuka, Masami; Fujita, Mikako. And the article was published in Molecules in 2019. Application In Synthesis of 4-Cyanobenzyl bromide The author mentioned the following in the article:

Imatinib, an Abelson (ABL) tyrosine kinase inhibitor, is a lead mol.-targeted drug against chronic myelogenous leukemia (CML). To overcome its resistance and adverse effects, new inhibitors of ABL kinase are needed. Our previous study showed that the benzyl ester of gypsogenin (1c), a pentacyclic triterpene, has anti-ABL kinase and a subsequent anti-CML activity. To optimize its activities, benzyl esters of carefully selected triterpenes (PT1-PT6), from different classes comprising oleanane, ursane and lupane, and new substituted benzyl esters of gypsogenin (GP1-GP5) were synthesized. All of the synthesized compounds were purified and charachterized by different spectroscopic methods. Cytotoxicity of the parent triterpenes and the synthesized compounds against CML cell line K562 was examined; revealing three promising compounds PT5, GP2 and GP5 (IC50 5.46, 4.78 and 3.19 microM, resp.). These compounds were shown to inhibit extracellular signal-regulated kinase (ERK) downstream signaling, and induce apoptosis in K562 cells. Among them, PT5 was identified to have in vitro activity (IC50 = 1.44 microM) against ABL1 kinase, about sixfold of 1c, which was justified by mol. docking. The in vitro activities of GP2 and GP5 are less than PT5, hence they were supposed to possess other more mechanisms of cytotoxicity. In general, our design and derivatizations resulted in enhancing the activity against ABL1 kinase and CML cells. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanobenzyl bromide(cas: 17201-43-3Application In Synthesis of 4-Cyanobenzyl bromide)

4-Cyanobenzyl bromide(cas: 17201-43-3) is an important intermediate for pharmaceutical production. It can be used for the synthesis of a series of piperidine-linked aromatic diimidazolines, which have been synthesized as conformationally restricted congeners of the anti-Pneumocystis carinii (PCP) drug, Pentamidine.Application In Synthesis of 4-Cyanobenzyl bromide

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and evaluation of thymol-based synthetic derivatives as dual-action inhibitors against different strains of H. pylori and AGS cell line》 was written by Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Spano, Mattia; Secci, Daniela; Granese, Arianna; Sobolev, Anatoly P.; Grande, Rossella; Campestre, Cristina; Marcantonio, Maria Carmela Di; Mincione, Gabriella. Electric Literature of C8H6BrNThis research focused onthymol ether preparation helicobacter pylori antibacterial gastric adenocarcinoma; AGS cells; Helicobacter pylori; drug resistance; dual-action agents, antimicrobial activity; semi-synthesis; thymol. The article conveys some information:

Herein, the synthesis of a new series of thymol-based ethers I [R = Me, H2C:CH, CN, EtO2C, Ph, 2-BrC6H4, etc.] and their microbiol. screening against eight strains of H. pylori and the cytotoxic activity against human gastric adenocarcinoma (AGS) cells are reported. Structural anal. comprehended elemental anal. and 1H/13C/19F NMR spectra. The anal. of structure-activity relationships within this mol. library of these structurally-related compounds showed that some chem. modifications of the OH group of thymol led to broad-spectrum growth inhibition on all isolates. Preferred substitutions were benzyl groups compared to alkyl chains and the specific presence of functional groups at para position of the benzyl moiety such as 4-CN and 4-Ph endowed the most anti-H. pylori activity toward all the strains with min. inhibitory concentration (MIC) values up to 4μg/mL. Poly-substitution on the benzyl ring was not essential. Moreover, several compounds characterized by the lowest min. inhibitory concentration/min. bactericidal concentration (MIC/MBC) values against H. pylori were also tested in order to verify a cytotoxic effect against AGS cells with respect to 5-fluorouracil and carvacrol. In the experiment, the researchers used many compounds, for example, 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)

4-Cyanobenzyl bromide(cas: 17201-43-3) can reacts with 2H-tetrazole in the presence of KOH to yield 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile. And it may be used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
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Kwon, Ye-Mi; Kim, Sou Hyun; Jung, Young-Suk; Kwak, Jae-Hwan published their research in Pharmaceuticals in 2021. The article was titled 《Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells》.Recommanded Product: 17201-43-3 The article contains the following contents:

A series of twenty-six compounds of furfuryl or benzyl tetrahydropyrazino[1,2-a]indole analogs were synthesized and evaluated for cytotoxic activity against the estrogen receptor (ER)-pos. breast cancer cell line (MCF-7) and the epidermal growth factor receptor (EGFR) over-expressed triple-neg. breast cancer cell line (MDA-MB-468). Among them, compounds 2b, 2f and 2i showed more potent activity and selectivity against MDA-MB-468 cells than gefitinib, as an EGFR- tyrosine kinase inhibitor. In addition, it was confirmed by means of isobologram anal. of combinational treatment with gefitinib that they have a synergistic effect, especially compounds 2b and 2f, which inhibit Akt T308 phosphorylation. Moreover, it was confirmed that 2-benzyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs (2b, 2f, and Ref 2) tend to selectively inhibit PI3Kβ, which is involved in the phosphorylation of Akt. In addition to this study using 4-Cyanobenzyl bromide, there are many other studies that have used 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3) was used in this study.

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Recommanded Product: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Yang, Yongliang; Luo, Na; Lin, Shiyun; Yao, Huan; Cai, Yaqi published an article in ACS Catalysis. The title of the article was 《Cyano Substituent on the Olefin Linkage: Promoting Rather than Inhibiting the Performance of Covalent Organic Frameworks》.Recommanded Product: 17201-43-3 The author mentioned the following in the article:

It is generally believed that the electron-withdrawing cyano group in the olefin linkage would inhibit the stability and π-conjugation of covalent organic frameworks (COFs), which raises concerns about their optoelectronic properties. However, the structure-activity relationship between the structure of olefin linkages and properties of COFs is still inconclusive. In this work, imine-, vinylene-, and acrylonitrile-linked COFs with identical triphenyltriazine building blocks were designed and synthesized. Our work demonstrated that construction of acrylonitrile linkages not only enhanced the chem. stability and photostability but also led to remarkable optoelectronic properties with a record fluorescence quantum yield of 35.37% in the solid state. Further, the acrylonitrile linkage endows TTAN-COF/Pt NPs with superior and durable photocatalytic activity in both the hydrogen evolution reaction (11.94 mmol g-1 h-1; BET surface area, 739.28 m2 g-1) and aerobic oxidation reaction. This work demonstrates that the acrylonitrile linkage can significantly enhance the optoelectronic properties and photocatalytic activities of COFs compared with the highly π-conjugated vinylene linkage, providing a valuable reference for the design of optoelectronic functional materials. In the experiment, the researchers used 4-Cyanobenzyl bromide(cas: 17201-43-3Recommanded Product: 17201-43-3)

4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Recommanded Product: 17201-43-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts