Category: 166329-43-7

SDS of cas: 166329-43-7. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about A Phosphorus(III)-Mediated (4+1)-Cycloaddition of 1,2-Dicarbonyls and Aza-o-Quinone Methides to Access 2,3-Dihydroindoles. Author is Eckert, Kaitlyn E.; Lepore, Antonio J.; Ashfeld, Brandon L..

A [4+1]-cycloaddition was reported between 1,2-dicarbonyls and aza-o-quinone methide precursors to access 2,3-dihydroindoles e.g. I bearing a tetra-substituted carbon center. The utilization of dioxyphospholenes as carbene surrogates provided dihydroindoles in 20-90% yield, wherein the electronic nature of the dioxyphospholene impacts its role in the reaction.

This compound(tert-Butyl (2-(bromomethyl)phenyl)carbamate)SDS of cas: 166329-43-7 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Inhibition of Nucleoside Transport by New Analogues of 4-Nitrobenzylthioinosine: Replacement of the Ribose Moiety by Substituted Benzyl Groups.Quality Control of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

4-Nitrobenzylthioinosine (NBTI, 1) is a well-known inhibitor for the nucleoside transport protein ENT1. However, its highly polar nature is unfavorable for oral absorption and/or penetration into the CNS. In the search for compounds with lower polarity than NBTI we replaced its ribose moiety by substituted benzyl groups. Halogen, hydroxyl, (trifluoro)methyl(-oxy), nitro, and amine functionalities were among the substituents at the benzyl group. In general, substitution of the benzyl group resulted in a lower affinity for ENT1. Only 2-hydroxyl substitution showed a higher affinity. Most likely this is the result of hydrogen bonding. Substitution at the 2-position of the benzyl group with aryl groups was also addressed. Compared to parent compound carrying a 2-phenylbenzyl group, all synthesized analogs gave higher affinities. Introduction of fluoro, trifluoromethyl, methoxy, and hydroxyl groups at the Ph group clearly showed that addition to the 4-position was preferable. Despite the highly different character of a ribose and a benzyl group, Ki values in the low nanomolar range were obtained for the benzyl-substituted derivatives Compound LUF5919, and compound LUF5929, displayed the highest affinity (Ki = 39 nM for both compounds), having a polar surface area of 101 Å2 and 85 Å2, resp.

The article 《Inhibition of Nucleoside Transport by New Analogues of 4-Nitrobenzylthioinosine: Replacement of the Ribose Moiety by Substituted Benzyl Groups》 also mentions many details about this compound(166329-43-7)Quality Control of tert-Butyl (2-(bromomethyl)phenyl)carbamate, you can pay attention to it, because details determine success or failure

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Beilstein Journal of Organic Chemistry called The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors, Author is Roper, Kimberley A.; Lange, Heiko; Polyzos, Anastasios; Berry, Malcolm B.; Baxendale, Ian R.; Ley, Steven V., which mentions a compound: 166329-43-7, SMILESS is O=C(OC(C)(C)C)NC1=CC=CC=C1CBr, Molecular C12H16BrNO2, Related Products of 166329-43-7.

Herein, we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction of alcs., e.g., PhCH2OH and Ph(CH2)4OH, in flow-chem. processing, to generate various brominated products, e.g., PhCH2Br and Ph(CH2)4Br, with high purity and in excellent yields, and with no requirement for further off-line purification

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 166329-43-7, is researched, Molecular C12H16BrNO2, about Antimicrobial effects of novel siderophores linked to β-lactam antibiotics, the main research direction is antibiotic beta lactam linked siderophore preparation antimicrobial effect; monobactam linked siderophore preparation antimicrobial effect; cephalosporin linked siderophore preparation antimicrobial effect; structure activity relationship beta lactam linked siderophore antibacterial; chimeric beta lactam preparation antimicrobial effect.Safety of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

As a strategy to increase the penetration of antibiotic drugs through the outer membrane of Gram-neg. pathogens, facilitated transport through siderophore receptors has been frequently exploited. Hydroxamic acids, catechols, or very close isosteres of catechols, which are mimics of naturally occurring siderophores, have been used successfully as covalently linked escorting moieties, but a much wider diversity of iron binding motifs exists. This observation, coupled to the relative lack of specificity of siderophore receptors, prompted us to initiate a program to identify novel, noncatechol siderophoric structures. We screened over 300 compounds for their ability to (1) support growth in low iron medium of a Pseudomonas aeruginosa siderophore biosynthesis deletion mutant, or (2) compete with a bactericidal siderophore-antibiotic conjugate for siderophore receptor access. From these assays we identified a set of small mols. that fulfilled one or both of these criteria. We then synthesized these compounds with functional groups suitable for attachment to both monobactam and cephalosporin core structures. Siderophore-β-lactam conjugates then were tested against a panel of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus strains. Although several of the resultant chimeric compounds had antimicrobial activity approaching that of ceftazidime, and most compounds demonstrated very potent activity against their cellular targets, only a single compound was obtained that had enhanced, siderophore-mediated antibacterial activity. Results with tonB mutants frequently showed increased rather than decreased susceptibilities, suggesting that multiple factors influenced the intracellular concentration of the drugs.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Jie; Dodd, Robert H. researched the compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate( cas:166329-43-7 ).Formula: C12H16BrNO2.They published the article 《Synthesis of 1,4-benzodiazepine-1-carbothioamides, bicyclic analogs of the TIBO-type anti-HIV agents》 about this compound( cas:166329-43-7 ) in Journal of Heterocyclic Chemistry. Keywords: TIBO analog preparation HIV virucide; benzodiazepinecarbothioamide TIBO analog preparation HIV. We’ll tell you more about this compound (cas:166329-43-7).

A series of N’-substituted 1,4-benzodiazepine-1-carbothioamides were prepared by reacting the precursor 1,4-benzodiazepine with the corresponding N-substituted isothiocyanates or with sodium thiocyanatotrifluoroacetic. Despite the structural resemblance of these mols. with the potent TIBO-type anti-HIV compound R82150, none of the compounds prepared displayed no anti-HIV activity in vitro.

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Xu, Cong; Feng, Yu; Li, Faju; Han, Jiahong; He, Yan-Mei; Fan, Qing-Hua published an article about the compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate( cas:166329-43-7,SMILESS:O=C(OC(C)(C)C)NC1=CC=CC=C1CBr ).HPLC of Formula: 166329-43-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:166329-43-7) through the article.

In the presence of (N-tosyldiphenylethanediamine)(p-cymene)ruthenium complexes, either using the ionic liquid (bmim)NTf2 as solvent or using achiral (diarylimidazolylidene)gold complexes in hexafluoroisopropanol, alkynylanilines such as I underwent chemoselective tandem hydroamination and enantioselective hydrogenation reactions to yield nonracemic tetrahydroquinolines such as II, nonracemic indolines, and nonracemic tetrahydrobenzazepines. The method was used to prepared the tetrahydroquinoline alkaloid (-)-angustureine.

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Andres, J. Ignacio; Alonso, Jose M.; Fernandez, Javier; Iturrino, Laura; Martinez, Pedro; Meert, Theo F.; Sipido, Victor K. published the article 《2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT2C antagonist with potential anxiolytic properties》. Keywords: dimethylaminomethyltetrahydroisoxazolopyridobenzazepine preparation 5HT antagonist.They researched the compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate( cas:166329-43-7 ).Product Details of 166329-43-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:166329-43-7) here.

The synthesis of 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,4-c]-[2]benzazepine and 2-(dimethylaminomethyl)-2,3,3a,8-tetrahydroisoxazolo[3,2-a]pyrido[3,2-c]-[2]benzazepine via a new route is reported. The affinities for several receptors as well as the m-chlorophenylpiperazine antagonistic activity of the compounds synthesized are described.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of an Achiral Gold Complex/Chiral Bronsted Acid Binary System, the main research direction is consecutive intramol hydroamination asym transfer hydrogenation relay catalysis; achiral gold complex chiral Bronsted acid binary catalysis.Product Details of 166329-43-7.

Consecutive hydroamination/asym. transfer hydrogenation under relay catalysis of an achiral gold complex/chiral Bronsted acid binary system has been described for the direct transformation of 2-(2-propynyl)aniline derivatives into tetrahydroquinolines with high enantiomeric purity.

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Reference of tert-Butyl (2-(bromomethyl)phenyl)carbamate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Photoredox-Catalyzed Trifluoromethylative Intramolecular Cyclization: Synthesis of CF3-Containing Heterocyclic Compounds. Author is Han, Hong Sik; Oh, Eun Hye; Jung, Young-Sik; Han, Soo Bong.

In the presence of Ir(ppy)3 and under blue LED irradiation, arylalkynyl alcs. and protected amines and an alkynyl thiol underwent chemoselective and regioselective trifluoromethylation and cyclization reactions mediated by Li2CO3 in dry MeCN to yield trifluoromethylated cyclic enol ethers and amines and a dihydrothiopyran such as I (R = 4-MeCONHC6H4, 4-TsNHC6H4, 4-BocNHC6H4, Ph, 4-t-BuC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4; R1 = H, Me; X = O, TsN, S; Ts = 4-MeC6H4SO2; Boc = t-BuOCO) in 41-80% yields. Seven- and eight-membered cyclic enol ethers were also prepared using this method.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tandem Gold-Catalyzed Dehydrative Cyclization/Diels-Alder Reactions: Facile Access to Indolocarbazole Alkaloids, published in 2015-04-03, which mentions a compound: 166329-43-7, mainly applied to indolocarbazole alkaloid synthesis tandem dehydrative cyclization Diels Alder cycloaddition, Quality Control of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

A gold-catalyzed synthesis of cyclic 2-oxodienes from readily prepared propargyl alcs. and the subsequent Diels-Alder reaction are reported. The dehydrative cyclization reactions proceeded smoothly, and the dienes formed in situ were demonstrated to undergo cycloaddition with a variety of dienophiles. This method offers a new strategy for the synthesis of indolocarbazole alkaloids, whereby the convergent synthetic design allows for differentiation between the indole nitrogens.

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