Category: 16213-85-7

Electric Literature of 16213-85-7, The chemical industry reduces the impact on the environment during synthesis 16213-85-7, name is 2-(2,5-Dimethylphenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

The organic layer obtained in the second step above,250g (1.5mol) of 60% sulfuric acid aqueous solution and 50g (0.8mol) of glacial acetic acid,Add to the 500mL four-necked bottle in sequence,Heat up to 120-130 ,Insulation reaction for 10h.GC detected that the reaction material 2,5-dimethylacetonitrile was completely reacted.After the reaction,After cooling to room temperature,Using para-xylene extraction,Add anhydrous magnesium sulfate to the organic layer to dry,After filtration, proceed directly to the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2,5-Dimethylphenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dalian Qikai Pharmaceutical Technology Co., Ltd.; Yang Yongzheng; Pei Xiong; Zhang Hongxue; Jiang Dianbao; (10 pag.)CN111072470; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16213-85-7, name is 2-(2,5-Dimethylphenyl)acetonitrile, A new synthetic method of this compound is introduced below., name: 2-(2,5-Dimethylphenyl)acetonitrile

To a stirred solution of sodium ethoxide (21% in ethanol, 5.34 mL, 68.9 mmol) was added methyl 2-methoxyacetate (5.34 mL, 51.7 mmol) and 2-(2,5-dimethylphenyl)acetonitrile (5.00 g, 34.5 mmol). The resulting reaction mixture was heated to reflux for 14 hours. The reaction was cooled, concentrated, diluted with ethyl acetate (80 mL), and washed with hydrochloric acid (2N). The combined organic layer was dried over sodium sulfate, filtered, and concentrated. Purification by flash column chromatography provided the title molecule as a pale yellow oil (4.00 g, 53%) : ESIMS m/z 218 ([M+H]+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DOW AGROSCIENCES LLC; GIAMPIETRO, Natalie C.; BAUM, Erich W.; FISCHER, Lindsey G.; GOLDSMITH, Miriam E.; CROUSE, Gary D.; RENGA, James M.; SPARKS, Thomas C.; (234 pag.)WO2016/99929; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts