Category: 160892-07-9

Related Products of 160892-07-9, These common heterocyclic compound, 160892-07-9, name is 5-Bromoisophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound D (12.77 g, 17.86 mmol) and 5-bromoisophthalonitrile (3.20 g, 15.53 mmol) were completely dissolved in 210 ml of tetrahydrofuran in a 500 ml round-bottomed flask under nitrogen atmosphere, and 2M potassium carbonate aqueous solution (105 ml) And tetrakis(triphenylphosphine) palladium (0.54 g, 0.47 mmol) was added thereto, followed by heating and stirring for 3 hours.The temperature was lowered to room temperature, the water layer was removed, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and recrystallized from 120 ml of tetrahydrofuran to obtain Compound 9 (8.42 g, yield 76%).

Statistics shows that 5-Bromoisophthalonitrile is playing an increasingly important role. we look forward to future research findings about 160892-07-9.

Reference:
Patent; LG Chem, Ltd.; Cha Yong-beom; Kim Yeon-hwan; Jeon Sang-yeong; Cho Yeon-ho; Lee Seong-jae; Han Su-jin; (53 pag.)KR2019/44973; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 160892-07-9, The chemical industry reduces the impact on the environment during synthesis 160892-07-9, name is 5-Bromoisophthalonitrile, I believe this compound will play a more active role in future production and life.

In a nitrogen atmosphere5-Bromoisophthalonitrile (30.0 g, 144.9 mmol)And (3,5-dichlorophenyl) boronic acid (30.4 g, 159.4 mmol)Were added to 400 ml of tetrahydrofuran, and the mixture was stirred and refluxed.After this, potassium carbonate (60.1 g, 434.7 mmol)In 180 ml of waterAfter thoroughly stirring, tetrakistriphenyl-phosphinopalladium (5.0 g, 4.4 mmol) was added thereto. After 8 hours of reaction, the temperature was lowered to room temperature and filtered.The filtrate was extracted with chloroform and water, and then the organic layer was dried with magnesium sulfate.The organic layer was then distilled under reduced pressure and recrystallized using ethyl acetate.The resulting solid was filtered and dried to give Compound 5A (30.5 g, 77%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoisophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LG CHEM, LTD.; JUNG, Min Woo; LEE, Dong Hoon; HUH, Jung oh; JANG, Boon jae; KANG, Min young; HEO, Dong Uk; HAN, Mi yeon; (26 pag.)KR2017/92131; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 160892-07-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160892-07-9 name is 5-Bromoisophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromoisophthalonitrile (1 g, 48.3 mmol), 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolo[3,2,1-jk]carbazole (1.77 g, 48.3 mmol) were dissolved in 1,4dioxane (50 ml). K2CO3 (1.34 g, 96.6 mmol) was dissolved in water and poured into the mixture. The reaction mixture was stirred with N2 bubbling for 30 min and refluxed overnight. After cooling to room temperature, the mixture was filtered and diluted with methylene chloride and washed with distilled water. The organic layer was dried over anhydrous MgSO4 and evaporated in vacuum. And then, the product was isolated by column chromatography on a silica gel.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoisophthalonitrile, and friends who are interested can also refer to it.

Reference:
Patent; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY; LEE, Junyeob; IM, Yirang; (37 pag.)US2018/114924; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts