Category: 159847-80-0

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 159847-80-0 as follows. category: nitriles-buliding-blocks

4-Amino-3-cyano-benzoic acid methyl ester (1.4 g, 7.95 mmol) was dissolved in a mixed solution of tetrahydrofuran and methanol (1/1, 50 mL), and iodine (I2, 2.2 g, 8.74 mmol) and silver nitrate (AgNO3, 1.5 g, 8.74 mmol) were added dropwise thereto. The mixture was stirred for 6 hours at room temperature and filtered with celite. The filtrate was added with 10% sodium thiosulfate aqueous solution and extracted with ethyl acetate. The extract was washed with brine, dried with anhydrous magnesium sulfate and filtered. The filtrate was distilled under reduced pressure. The residue was separated by column chromatography to obtain the title compound (2.0 g, 84%).

According to the analysis of related databases, 159847-80-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES LTD.; PAEK, Seung Yup; LEE, Sung Bae; PARK, Deok Seong; LEE, Won Hyung; WO2014/129796; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 159847-80-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 159847-80-0, name is Methyl 4-amino-3-cyanobenzoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-Amino-3-cyano-benzoic acid methyl ester (3.2 g, 10 mmol) in tetrahydrofurane/ water (110 ml, 1:1) was added lithium hydroxide hydrate (2.3 g, 30 mmol), the reaction mixture was stirred at room temperature for 20 hours and added hydro chloric acid (1 M) to pH = 3. From the mixture was tetrahydrofurane distilled of and the title compound precipitated out of solution.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-cyanobenzoate, other downstream synthetic routes, hurry up and to see.