Category: 1591-37-3

Electric Literature of 1591-37-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1591-37-3 name is 2-Amino-6-methoxybenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 36 2′-Cyano-3′-methoxyoxanilic acid ethyl ester. 80/71 2-Amino-6-methoxybenzonitrile (4.67 g, 0.0315 mole) is condensed with 3.88 ml (0.0346 mole) of ethyl oxalylchloride in a manner similar to example 3, giving 5.0 g of the title compound, m.p. 142-145C., after crystallization from toluene. Elemental Analysis for C12 H12 N2 O4: Calc’d: C, 58.06; H, 4.87; N, 11.29. Found: C, 58.21; H, 4.93; N, 11.02.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-6-methoxybenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; American Home Products Corporation; US3966965; (1976); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1591-37-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1591-37-3, name is 2-Amino-6-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 46 9-Amino-8-methoxy-4-oxa-1,2,3,4-tetrahydroacridine Following the method of Example 7, but substituting 2-amino-6-methoxybenzonitrile for anthranilonitrile afforded the title compound (11%, m.p. 205-207 C.). 1 H-NMR (CDCl3, 300 MHz,delta): 2H, m, 7.33 ppm; 1H, dd, 6.57 ppm (J=3, 6 Hz); 2H, bs, 5.92 ppm; 2H, t, 4.29 ppm (J=2, 6 Hz); 3H, s, 3.95 ppm; 2H, t, 2.5 ppm (J=2, 6 Hz); 2H, m, 2.13-2.07 ppm; TLC: (90:10:1-methylene chloride:methanol:28% aqueous ammonia) Rf -0.49.

The synthetic route of 2-Amino-6-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US5202440; (1993); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts