Category: 1572-52-7

Adding a certain compound to certain chemical reactions, such as: 1572-52-7, name is 2-Methylenepentanedinitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1572-52-7, Product Details of 1572-52-7

(0099) At 0 C., 8.96 g (56.07 mmol) of bromine are slowly added dropwise to a solution of 7.0 g (65.96 mmol) of 2-methylenepentanedinitrile. The reaction mixture is then stirred at 35 C. for 2 hours. The reaction mixture is then once more cooled to 0 C., and 6.52 g (85.75 mmol) of 1-hydroxyurea are added. A solution of 7.13 g (178.09 mmol) of NaOH in 15 ml of water is then slowly added dropwise at 0 C., and the mixture is boiled under reflux for 3.5 hours. The solvents are concentrated and the residue is then dissolved in 20 ml of water and extracted three times with in each case 10 ml of dichloromethane. The combined organic phases are dried over sodium sulfate and concentrated. Yield: 2.8 g (29%). (0100) 1H-NMR, DMSO-d6, 400 MHz: 8.24 (s, 1H), 5.56 (bs, 2H), 2.71 (t, 2H), 2.60 (t, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methylenepentanedinitrile, and friends who are interested can also refer to it.

Reference:
Patent; BAYER CROPSCIENCE AG; KOEHN, Arnim; AHRENS, Hartmut; BRAUN, Ralf; HEINEMANN, Ines; TIEBES, Joerg; WALDRAFF, Christian; DIETRICH, Hansjoerg; GATZWEILER, Elmar; ROSINGER, Christopher Hugh; SCHMUTZLER, Dirk; US2015/307462; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-52-7, name is 2-Methylenepentanedinitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Methylenepentanedinitrile

a. 426 g (4 moles) of 2-methyleneglutaronitrile, 264 g (4 moles) of cyclopentadiene, 4 g of hydroquinone and 500 ml of benzene are heated in a pressure autoclave at 160 and under a maximum pressure of 3 bars, with stirring, for 10 hours. The mixture obtained after cooling is concentrated in vacuo (ca. 12 Torr), the residue twice extracted with 1.5 liters of petroleum ether each time and then extracted in high vacuum. The crude product is obtained as colourless oil, B.P. 115-128/0.03 Torr, which is dissolved in 300 ml of ethanol. On storage of this solution in a refrigerator overnight, there crystallises 2-exo-cyano-5-norbornene-2-endo-propionitrile, M.P. 40-42.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1572-52-7.

Reference:
Patent; Ciba-Geigy Corporation; US4015007; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1572-52-7, These common heterocyclic compound, 1572-52-7, name is 2-Methylenepentanedinitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference example 14 3-(3,4-Dimethylphenylthio)-2-(2-methoxycarbonylethyl)propionic acid A mixture of 3,4-dimethylbenzenethiol (0.59 ml), 2-methyleneglutaronitrile (0.48 ml), ethanol (10 ml), and triton B (40% ethanol solution, 5 drops) was refluxed for 5 hours. After the reaction mixture was concentrated in vacuo, the resulting residue was dissolved in chloroform, washed with water, and dried over MgSO4. The solvent was evaporated at reduced pressure, and the residue was purified by flash column chromatography on silica eluding with benzene/ethyl acetate (7:1) to give 1.18 g of 2-(3,4-dimethylphenylthiomethyl)glutaronitrile as oil. IR (neat): nuCN2230 cmmin1 NMR (CDCl3)

Statistics shows that 2-Methylenepentanedinitrile is playing an increasingly important role. we look forward to future research findings about 1572-52-7.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP508004; (1992); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-52-7, name is 2-Methylenepentanedinitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H6N2

129 g (1 M) of N-(2-aminoethyl)imidazolidin-2-one and2 g of water are charged to a 500 cm3 reactor equipped with a mechanical stirrer, a jacket for heating, a dropping funnel and a system for rendering inert with nitrogen. The product is brought to 75-80 C. and then 116 g (1.1 M) of methyleneglutaronitrile are run in slowly. Reaction is allowed to take place, the reaction being monitored by potentiometric titration of the primary amines to given secondary amines. At the end of the reaction, the dinitrile is obtained with a yield of 89%. The product can be used as is.

According to the analysis of related databases, 1572-52-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1572-52-7, These common heterocyclic compound, 1572-52-7, name is 2-Methylenepentanedinitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

130 g (1 M) of N-(2-hydroxyethyl)imidazolidin-2-one and 2 g of potassium hydroxide pellets are charged to a 500 cm3 reactor equipped with a mechanical stirrer, a jacket forheating, a dropping funnel and a system for rendering inertwith nitrogen. The product is brought to 80 C. and then 116g (1.1 M) of methyleneglutaronitrile are run in slowly. At theend of the reaction, when there is virtually no more methyleneglutaronitrile, the catalyst is neutralized with an acid.The expected dinitrile is obtained with a yield of 95%. Theproduct can be used as is or purified by distillation in orderto separate it from the excess methyleneglutaronitrile.

Statistics shows that 2-Methylenepentanedinitrile is playing an increasingly important role. we look forward to future research findings about 1572-52-7.

Reference:
Patent; Arkema France; Gillet, Jean-Philippe; Disson, Jean-Pierre; Van Hemelryck, Bruno; (13 pag.)US10047195; (2018); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1572-52-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-52-7, name is 2-Methylenepentanedinitrile, This compound has unique chemical properties. The synthetic route is as follows.

REFERENCE EXAMPLE 1 3-(3,4-Dichlorophenylthio)-2-(2-methoxycarbonylethyl)propionic acid A mixture of 3,4-dichlorobenzenethiol (3.00 ml), methyleneglutaronitrile (2.57 ml), ethanol (25 ml), and triton B (40% methanol solution, 10 drops) was refluxed for 4 hours. After the reaction mixture was concentrated in vacuo, the resulting residue was dissolved in chloroform, washed with water, and dried over MgSO4. The solvent was evaporated at reduced pressure, and the residue was recrystallized from diethyl ether-hexane to give 6.14 g of 2-(3,4-dichlorophenylthiomethyl)glutaronitrile. Melting point: 53-55 C. IR (KBr): nuCN 2240 cm-1

The chemical industry reduces the impact on the environment during synthesis 2-Methylenepentanedinitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; US5145869; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts