Category: 1558-82-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1558-82-3, name is Ethyl N-cyanoacetimidate, A new synthetic method of this compound is introduced below., Product Details of 1558-82-3

EXAMPLE 2 Preparation of 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-[(N-cyano-acetimidoyl)amino]-2H-benzo[b]pyran-3-ol To 1.23 g of ethyl N-cyanoacetimidate, 2.18 g of 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-amino-2H-benzo[b]pyran-3-ol was added, and the mixture was stirred at a temperature of from 100 to 120 C. for 2 hours. The reaction mixture was cooled, then dissolved in 100 ml of ethyl acetate, washed twice with a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. Then, ethyl acetate was distilled off under reduced pressure. The residual oily substance was recrystallized from ethyl acetate/n-hexane to obtain 1.75 g of the above identified compound in the form of crystals. Melting point: 240-243 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; US5095016; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1558-82-3, A common heterocyclic compound, 1558-82-3, name is Ethyl N-cyanoacetimidate, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 7 Preparation of 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-[N-methyl-(N-cyano-acetimidoyl)amino]-2H-benzo[b]pyran-3-ol To 2.80 g of ethyl N-cyanoacetimidate, 4.65 g of 6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-methylamino-2H-benzo[b]pyran-3-ol was added, and the mixture was reacted under stirring at a temperature of from 100 to 120 C. for 2 hours. The reaction mixture was cooled, then dissolved in 100 ml of ethyl acetate, washed twice with a saturated sodium chloride aqueous solution and then dried over anhydrous sodium sulfate. Then, ethyl acetate was distilled off under reduced pressure. The residual solid was recrystallized from ethanol to obtain 2.34 g of the above identified compound in the form of crystals. Melting point: 250-251 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; US5095016; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1558-82-3,Some common heterocyclic compound, 1558-82-3, name is Ethyl N-cyanoacetimidate, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

the last step into the reactor material, heated to 75 ,Add 520kgCyanoethyl ester, Dropping 5 hours, dropping temperature at this temperature for 4 hours, and then cooled to room temperature, filtered to give acetamiprid, and then dried to obtain the finished product 995kg, content of 99%Yield 96%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl N-cyanoacetimidate, its application will become more common.

Reference:
Patent; Jiangsu Changqing Agrochemical Co., Ltd.; Lv Liangzhong; He Shuze; Ma Changqing; Ding Huaping; (5 pag.)CN107501172; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1558-82-3, name is Ethyl N-cyanoacetimidate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Ethyl N-cyanoacetimidate

A mixture of 1.2 g (0.004 mol) of 2-chloro-4,5,6,7-tetrahydrothiazole [5,4-c] pyridine trifluoroacetate,0.67 g (0.006 mol)N-cyanoethyl esterWas added to a reaction flask equipped with 30 ml of methanol,0.73 g (0.0048 mol) of DBU was added,Heating to reflux reaction,After 2 hours the TLC monitoring reaction was complete,Cooling white solid precipitation, the filter that white solid 0.49g,

According to the analysis of related databases, 1558-82-3, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1558-82-3, name is Ethyl N-cyanoacetimidate, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Step F: Preparation of /V-cvaiotaio-/V-(2-(5-(2.5-dinuorophenylV3-f(.S’)-2- ntethoxypropanoyl)-2-phenyl-23-diln dro-1.3.4-thiadiaychi)l-2-yl’)ethyl)acetaniidine: To a solution of ethyl N-cyanoacctimidate (0.025 g, 0.22 mmol) and (2.USD>l-(2-(2-aminoclhyl)-5-(2,5- difluororhohenyl)-2 -phenyl- 1 ,3,4-thiadiazol-3(2//)-yl)-2-mcthoxypropan- 1 -one hydrochloride (0.018 g, 0.038 mmol) in EtOH (0.3 mL) was added diisopropylethylamine (0.033 mL, 0.19 mmol). After stirring at room temperature for 14 hours, the mixture was diluted with 10% Na^CC^ (30 mL) and extracted with dichloromcthanc. The combined organics were dried over Na^SO4, filtered and concentrated under reduced pressure. The residue was chromatographcd (3% McOH in dichloromethane) to provide the product as a mixture of diastereomers (13.0 mg, 73% yield). MS ESI (+) m’z 472 (M+l) detected; 1H NMR (400 MHz, CDCl3) 67.51 (m, 2H).7.37 (m, 6H), 7.33 (m, 4H). 7.16 (m. 4H), 6.93 (br. t, IH, J = 4.7 Hz), 6.73 (br. t, IH, J = 4.7 Hz), 4.73 (m, 2H), 4.00 (m, 2H), 3.45-3.29 (m, 9H), 3.21 (m, I H), 2.82 (m, IH), 2.75 (m, IH), 2.16 (s, 3H), 2.15 (s, 3H), 1.46 (d5 3H,J = 6.3 Hz), 1.43 (d, 3H5 J = 7.0 Hz).

The synthetic route of 1558-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA, INC.; AHRENDT, Kateri; DELISLE, Robert, Kirk; HANS, Jeremy; LYSSIKATOS, Joseph, P.; ROBINSON, John, E.; WALLACE, Eli, M.; ZHAO, Qian; WO2008/42928; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

1558-82-3,Some common heterocyclic compound, 1558-82-3, name is Ethyl N-cyanoacetimidate, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 33Preparation of N’-cyano-N-(cyanomethyl)-N-methylacetimidamideTo a solution of ethyl N-cyanoacetimidate (1.12 g; 10 mmol) in ethanol (20 mL) was add 2-(methylamino)acetonitrile (0.736 g; 10.5 mmol) and the reaction mixture was stirred at room temperature for 24 h. The volatiles were removed under reduced pressure and the 1.36 g (100%) of the crude white solid were dried and used without further purification. ESI/APCI(+): 137 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl N-cyanoacetimidate, its application will become more common.

Reference:
Patent; KATHOLIEKE UNIVERSITEIT LEUVEN; US2012/316161; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts