In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 148932-68-7, name is 2-Amino-3-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2-Amino-3-methoxybenzonitrile
To a solution of sodium thiocyanate (4.06 g) in methanol(70 mL) was added bromine (1.35 mL) at -700C. The reaction mixture was stirred for 10 min, and 2-amino-3- methoxybenzonitrile (3.71 g) was added. The temperature was risen to room temperature, and the mixture was stirred for 2 hr. The reaction mixture was poured into ice water, and the precipitated crystals were collected by filtration, washed with water and dried to give the title compound (4.28 g, yield 84%) as colorless crystals. Melting point 121-122C.
The synthetic route of 148932-68-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA SAN DIEGO, INC.; WO2008/156757; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts