Category: 14447-18-8

Reference of 14447-18-8, These common heterocyclic compound, 14447-18-8, name is Benzyl cyanoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To 0.2 mmol of 3,4-dihydroxycinnamaldehyde in 3 mL EtOH a corresponding substituted acetonitrile or the like was added followed by addition of 0.4 mmol of piperidine. A dark red solution was stirred at 20 °ree;C for 0.5 h. 0.5 mL 1 N HC1 and 5 mL of H2O were added and EtOH was evaporated with the stream of N2. The precipitated powder was filtered off, washed with H2O and dried in a desiccator in vacuo in the presence of solid NaOH. Yields were 55-70%. For a list of obtained products (CRIX-38, CRIX-39, CRIV-42, CRIV-46, CRTX-79, CRVIII-33, CRVIII-34, CRVIII-50, CRVIII-51, CRVIII-52, CRVIII-53) see Tables 1 and 5. For the mass spectra and UV maxima see Tables 2 and 6. For the NMR data see Tables 3 and 7.

Statistics shows that Benzyl cyanoacetate is playing an increasingly important role. we look forward to future research findings about 14447-18-8.

Reference:
Patent; THE HOSPITAL FOR SICK CHILDREN; WO2005/12234; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14447-18-8, name is Benzyl cyanoacetate, A new synthetic method of this compound is introduced below., Product Details of 14447-18-8

The reactor is addedCyanoacetic acid benzyl ester 63 mL (0.5 mol)1-butyl-3- methyl imidazole trifluoroacetate126mL,N-octadecyl-3-aminoacrolein19 mL (0.1 mol) was homogeneously mixed,The oil bath was heated to a temperature of 90 C and incubated for 4 h to carry out the reaction,TLC detection (petroleum ether: dichloromethane 1: 2 development, sublimation iodine color) N-octadecyl-3-aminopropenal reaction completely, cooled to room temperature, organic solvent1,2-dichloroethane 60mL extraction 3 times, residual phase ion water washing vacuum drying and reuse,The organic phase was passed into the HCl gas and the reaction was followed by HPLC until the reaction was complete. Add concentrated ammonia to adjust the pH = 5-6, liquid separation, water use1,2-dichloroethane 20 mL x 3 times extraction,The organic layers were combined, washed with water and separated, and the solvent was distilled off under reduced pressure to give 1,2-dichloroethane2-chloronicotinic acid benzyl ester, pale yellow liquid 23.7g, the yield was 95.5%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Normal University; Liu Yufa; Mao Feifei; Zhang Hongtao; Kan Baohong; Sun Lin; Chen Dongmei; Qian Xiaoping; (11 pag.)CN105001154; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14447-18-8, name is Benzyl cyanoacetate, A new synthetic method of this compound is introduced below., Formula: C10H9NO2

2-Cyano-4,4,8-trimethyl-non-2-enoic acid benzyl ester: To a mixture of 2,2,6-Trimethyl-heptanal (1.05 g, 6.73 mmol), piperidine (0.19 mL, 2.01 mmol) and benzyl cyanoacetate (1.29 g, 7.4 mmol) in toluene (50 mL) was added glacial acetic acid (0.72 g, 12.1 mmol). The flask was fitted with a Dean-Stark trap, and the mixture was heated at reflux for 18. The mixture was cooled, treated with dilute HCl, and the layers were separated. The organics were washed with a saturated sodium bicarbonate solution followed by brine, and dried (MgSO4), filtered and concentrated. The residual oil was purified by silica gel chromatography (98/2 hexane/EtOAc) to give 1.3 g of 2-Cyano-4,4,8-trimethyl-non-2-enoic acid benzyl ester m/z 314 (M+).

The synthetic route of 14447-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Field, Mark John; Williams, Richard Griffith; US2004/157847; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14447-18-8 as follows. COA of Formula: C10H9NO2

In a 500 mL three-neck flask reactor equipped with a thermometer,Benzyl cyanoacetate 63 mL (0.5 mol) was added,Pyridine 10mL,N-octadecyl-3-aminoacrolein42mL (0.25mol),Place the prepared device in the microwave.Set microwave radiation conditions, 35C temperature,The microwave power is 20W and the frequency is 2450MHz.TLC test (petroleum ether:dichloromethane 1:2 development, sublimation iodine coloration) N-octadecyl-3-aminoacrolein reaction was complete, cooled to room temperature, HCl gas was introduced, and the reaction was continued under microwave irradiation ,HPLC followed the reaction until the reaction was over. Add concentrated ammonia to adjust the pH = 5-6, liquid,The aqueous layer was extracted with 1,2-dichloroethane (20 mL¡Á3 times), and the organic layers were combined and washed with water.The solvent 1,2-dichloroethane was distilled off under reduced pressure to obtain 2-chloronicotinic acid benzyl ester.The yellowish liquid was 59.1 g, and the yield was 95.4%.

According to the analysis of related databases, 14447-18-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shandong Normal University; Liu Yufa; Li Dechao; Gu Qiaolian; Sun Lin; Xu Jun; Zhao Jianxia; Cheng Guiying; (11 pag.)CN104945316; (2018); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 14447-18-8, These common heterocyclic compound, 14447-18-8, name is Benzyl cyanoacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Cyano-4,4,8-trimethyl-non-2-enoic acid benzyl ester: To a mixture of 2,2,6-Trimethyl-heptanal (1.05 g, 6.73 mmol), piperidine (0.19 mL, 2.01 mmol) and benzyl cyanoacetate (1.29 g, 7.4 mmol) in toluene (50 mL) was added glacial acetic acid (0.72 g, 12.1 mmol). The flask was fitted with a Dean-Stark trap, and the mixture was heated at reflux for 18. The mixture was cooled, treated with dilute HCl, and the layers were separated. The organics were washed with a saturated sodium bicarbonate solution followed by brine, and dried (MgSO4), filtered and concentrated. The residual oil was purified by silica gel chromatography (98/2 hexane/EtOAc) to give 1.3 g of 2-Cyano-4,4,8-trimethyl-non-2-enoic acid benzyl ester m/z 314 (M+)

The synthetic route of 14447-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Field, Mark John; Williams, Richard Griffith; US2005/65176; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts