Category: 143879-80-5

Some common heterocyclic compound, 143879-80-5, name is 2,3,4-Trifluorobenzonitrile, molecular formula is C7H2F3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2,3,4-Trifluorobenzonitrile

Scheme 21[0368] To 2,3,4-trifluorobenzonitrile (265 mg, 1.68 mmol) in a flask, a solution of D- leucine amide hydrochloride (282 mg, 1.68 mmol) and DIEA (0.880 mL, 5.06 mmol) in DMSO (5 mL) was added. After being stirred at room temperature for 68 h, water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2S04, concentrated in vacuo. The residue was purified by a silica gel column, eluted with 0-70% EtOAc in hexane to give (R)-2-(4-cyano-2,3-difluorophenylamino)-4-methylpentanamide (113 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 143879-80-5, its application will become more common.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong, J.; SONG, Yonghong; XU, Qing; KANE, Brian; BAUER, Shawn, M.; PANDEY, Anjali; WO2012/61418; (2012); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143879-80-5, name is 2,3,4-Trifluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2,3,4-Trifluorobenzonitrile

6,7-Difluoro-1H-inidazole-3-amine: [0237]; 0.32 cm3 of hydrazine monohydrate is added to 0.46 cm3 of 2,3,4-trifluorobenzonitrile in 10 cm3 of absolute ethanol. The medium is heated at about 75 C. for 17 hours, followed by addition of 10 cm3 of ethyl acetate, 5 cm3 of tetrahydrofuran and 5 cm3 of distilled water. The organic phase is separated out after settling the phases and is washed with 10 cm3 of distilled water and then with 10 cm3 of saturated aqueous sodium chloride solution. The organic phase is separated out after settling the phases, dried over magnesium sulfate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50 C.). The residue obtained is purified by chromatography under an argon pressure of 50 kPa, on a column of silica gel (particle size 40-60 mum; diameter 1.5 cm), eluting with a cyclohexane/ethyl acetate mixture (50/50 by volume). The fractions containing the expected product are combined and then evaporated under reduced pressure (2 kPa; 40 C.); after drying (90 Pa; 40 C.), 100 mg of 6,7-difluoro-1H-indazole-3-amine are obtained in the form of a white solid melting at 183 C. [0238] 1H NMR spectrum (300 MHz, (CD3)2SO d6, delta in ppm): 5.57 (unresolved complex: 2H); 6.93 (mt: 1H); 7.52 (ddd, J=8.5-4.5 and 1Hz: 1H); 12.01 (unresolved complex: 1H).

According to the analysis of related databases, 143879-80-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Lesuisse, Dominique; Dutruc-Rosset, Gilles; Halley, Franck; Babin, Didier; Rooney, Thomas; Tiraboschi, Gilles; US2004/132794; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 143879-80-5, These common heterocyclic compound, 143879-80-5, name is 2,3,4-Trifluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 4 1-(4-Amino-8-fluoro-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-one (Compound 4); 2,3,4-Trifluoro-benzonitrile (3.00 g, 19.1 mmol) is mixed with dimethylacetamide (30 mL). Formamidine acetate (1.99 g, 19.1 mmol) and diisopropylethyl amine (10 mL, 57.3 mmol) are added, and the resulting reaction mixture is slowly heated. Upon heating, the starting heterogeneous mixture slowly turns into a homogeneous solution. At 80 C., precipitates start to form. The reaction mixture proceeds at 80 C. for 30 minutes before it is cooled and filtered. The collected solid is further washed with DCM to afford 1.50 g of 7,8-Difluoro-quinazolin-4-ylamine (43% yield) as white solid. LC/MS found m/z=182 [M+H]+.

The synthetic route of 143879-80-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy; US2008/70935; (2008); A1;,
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Nitriles – Chemistry LibreTexts

143879-80-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143879-80-5, name is 2,3,4-Trifluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2,3,4-trifluorobenzonitrile (3 g, 19 mmol), tert-butyl carbazate (4 g, 30 mmol) and Hunig’s base were dissolved in dioxane (10 mL) and heated at 100 C. for 3 d. The mixture was concentrated and then partitioned between toluene (25 mL) and water (29 mL). The toluene layer was added to a column and chromatographed (silica gel, 10 to 40% ethyl acetate in hexanes) to give product as an oil. Recrystallization from ethyl acetate/hexanes gave N’-(4-cyano-2,3-difluoro-phenyl)-hydrazinecarboxylic acid tert-butyl ester (1.16 g, 22%) as a white powder. A second crop (0.5 g, 10%) was obtained as a slightly pinkish powder. LCMS (m/z): M+H=170.1 (loss of BOC).

The synthetic route of 2,3,4-Trifluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The chemical industry reduces the impact on the environment during synthesis 143879-80-5, name is 2,3,4-Trifluorobenzonitrile, I believe this compound will play a more active role in future production and life. 143879-80-5

0.32 cm3 of hydrazine monohydrate is added to 0.46 cm3 of 2,3,4-trifluorobenzonitrile in 10 cm3 of absolute ethanol. The medium is heated at about 75 C. for 17 hours and then 10 cm3 of ethyl acetate, 5 cm3 of tetrahydrofuran and 5 cm3 of distilled water are added. The organic phase is separated out after settling of the phases has taken place, and is washed again with 10 cm3 of distilled water and then with 10 cm3 of saturated aqueous sodium chloride solution. The organic phase is separated out after settling of the phases has taken place, dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (2 kPa; 50 C.). The residue obtained is purified by chromatography under an argon pressure of 50 kPa, on a column of silica gel (particle size 40-60 mum; diameter 1.5 cm), eluting with a cyclohexane/ethyl acetate mixture (50/50 by volume). The fractions containing the expected product are combined and then evaporated under reduced pressure (2 kPa; 40 C.); after drying (90 Pa; 40 C.), 100 mg of 6,7-difluoro-1H-indazole-3-amine are obtained in the form of a white solid melting at 183 C. [0561] 1H NMR spectrum (300 MHz, (CD3)2SO-d6, delta in ppm): 5.57 (unresolved peak: 2H); 6.93 (mt: 1H); 7.52 (ddd, J=8.5-4.5 and 1 Hz: 1H); 12.01 (unresolved peak: 1H).

The chemical industry reduces the impact on the environment during synthesis 143879-80-5. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Dutruc-Rosset, Gilles; Lesuisse, Dominique; Rooney, Thomas; Halley, Franck; US2004/14802; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

143879-80-5, The chemical industry reduces the impact on the environment during synthesis 143879-80-5, name is 2,3,4-Trifluorobenzonitrile, I believe this compound will play a more active role in future production and life.

4- 4-CYANO-2, 3-DIFLUORO-PHENYL)-PIPERAZINE-L-CARBOXYLIC ACID TERT-BUTYL ester To a solution OF N-BOC-PIPERAZINE (0.65 g) in DMA (20 mL) was slowly added a solution of 2, 3, 4-trifluorobenzonitrile (0.49 g) in DMA (10 mL). The reaction mixture was stirred for 2 hours at 80C. After such time the solvent was removed in vacuo and purified by column chromatography (SIO2) to yield the title compound as white solid (0.76 g).

The chemical industry reduces the impact on the environment during synthesis 2,3,4-Trifluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/23260; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts