Related Products of 143306-27-8, These common heterocyclic compound, 143306-27-8, name is 2-Fluoro-6-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Method AA Al 05 (500 mg), l-methyl-(4-methylamino)piperidine (440 muL) and Hnig base (600 muL) are suspended in 1.5 mL butanol and stirred for 1 h at 150 0C in a Biotage microwave. The reaction mixture is combined with water and DCM, the organic phase is separated off and dried.
The synthetic route of 143306-27-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2008/152014; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts