Category: 1403850-00-9

Related Products of 1403850-00-9On May 1, 2020 ,《Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis》 appeared in Organic Letters. The author of the article were Lux, Marcel; Klussmann, Martin. The article conveys some information:

The consecutive addition of acyl radicals and N-alkylindole nucleophiles to styrenes was established, as well as some addnl. radical-nucleophile combinations. Both aryl and aliphatic aldehydes give reasonable yields. The reaction proceeds best for α-substituted styrenes, effectively creating a quaternary all-carbon center. Some iridium-based photoredox systems are catalytically active; furthermore, a base is needed in this transformation. Radicals are formed by reductive perester cleavage and hydrogen atom transfer. In addition to this study using 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile, there are many other studies that have used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Related Products of 1403850-00-9) was used in this study.

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Related Products of 1403850-00-9

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Application of 1403850-00-9On September 18, 2020 ,《Development of Bronsted Base-Photocatalyst Hybrid Systems for Highly Efficient C-C Bond Formation Reactions of Malonates with Styrenes》 was published in ACS Catalysis. The article was written by Bas, Sebastian; Yamashita, Yasuhiro; Kobayashi, Shu. The article contains the following contents:

Bronsted base-photocatalyst hybrid systems were developed for reactions of malonates with styrene derivatives to afford dialkyl-((aryl)alkyl)malonates (R1)(Ar)CHCH(R2)CH(CO2R3) [R1 = H, Me, Ph, etc.; R2 = H, Me, Ph; R3 = Me, Et, i-Pr, etc.; Ar = Ph, 4-MeC6H4, 2-pyridyl, etc.]. The concept of this process lies in the photooxidation of catalytic amounts of the enolate to form reactive radicals that react with alkene double bonds under mild reaction conditions. This was an example of visible light activated C-C bond formation reactions of malonates with alkenes to realize high atom economy under very mild reaction conditions without using any transition metal catalysts. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Application of 1403850-00-9)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Application of 1403850-00-9

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Nitrile – Wikipedia,
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The author of 《Photoredox catalyzed dealkylative aromatic halogen substitution with tertiary amines》 were Lipilin, Dmitry L.; Frumkin, Alexander E.; Tyurin, Alexey Y.; Levin, Vitalij V.; Dilman, Alexander D.. And the article was published in Molecules in 2021. Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The author mentioned the following in the article:

A reaction of aromatic halides bearing electron-withdrawing groups with tertiary amines in the presence of an iridium catalyst under blue light irradiation is described. Products of the aromatic substitution of the halide by the dialkylamino fragment are obtained. The interaction of aryl radicals with tertiary amines to generate zwitterionic radical species is believed to be the key factor responsible for the reaction efficiency. In the experiment, the researchers used many compounds, for example, 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile

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Nitrile – Wikipedia,
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Gladkov, Anton A.; Chernov, Grigory N.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Dilman, Alexander D. published their research in Organic Letters on December 17 ,2021. The article was titled 《Photoredox Activation of Organozinc Reagents: Barbier-Type Reaction of Alkyl Halides with α-(Trifluoromethyl)styrenes》.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The article contains the following contents:

Organozinc reagents were activated under blue light irradiation using an organic photocatalyst to generate alkyl radicals. The radicals were trapped by α-(trifluoromethyl)styrenes leading to gem-difluorinated products after elimination of fluoride. The reaction was conveniently performed under Barbier conditions starting from organic iodides and bromides and elemental zinc. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile

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《Photoredox-Catalyzed Site-Selective Generation of Carbanions from C(sp3)-H Bonds in Amines》 was written by Murugesan, Kathiravan; Donabauer, Karsten; Narobe, Rok; Derdau, Volker; Bauer, Armin; Koenig, Burkhard. Formula: C43H30F2N4 And the article was included in ACS Catalysis on April 1 ,2022. The article conveys some information:

Herein, activation of a C(sp3)-H bond in the α-position to an amine via a carbanion intermediate was described. In the presence of several α-amine sites, only one specific position was selectively activated. Applying this protocol, the proposed carbanion intermediate was effectively trapped with different electrophiles such as deuterium (D+), tritium (T+), or carbonyl compounds compiling over 50 examples. Further, this methodol. was used to install deuterium or tritium in different drug-derivatives (>10 drugs) at a selected position in a late-stage functionalization. In addition, the protocol was suitable for a gram-scale synthesis, and a detailed mechanistic investigation was carried out to support our hypothesis. The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Formula: C43H30F2N4)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Formula: C43H30F2N4

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Nitrile – Wikipedia,
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The author of 《Photocatalytic carbanion generation from C-H bonds – reductant free Barbier/Grignard-type reactions》 were Berger, Anna Lucia; Donabauer, Karsten; Koenig, Burkhard. And the article was published in Chemical Science in 2019. Electric Literature of C43H30F2N4 The author mentioned the following in the article:

A redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction was reported. The combination of photo- and hydrogen atom transfer (HAT) catalysis enabled the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical was reduced in situ by the organic photocatalyst to a carbanion, which was able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcs. ArCR1R2C(OH)R3R4 [R1 = R2 = H, Me, R1 = H, R2 = Me; R3 = R4 = Me, Et, n-Bu, R3 = H, Me, R4 = Me, Et, i-Pr, etc; Ar = 2-thienyl, Ph, 4-MeOC6H4, etc.]. In the experiment, the researchers used many compounds, for example, 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Electric Literature of C43H30F2N4)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Electric Literature of C43H30F2N4

Referemce:
Nitrile – Wikipedia,
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Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrileOn May 21, 2021 ,《Light-Mediated Sulfur-Boron Exchange》 appeared in Organic Letters. The author of the article were Panferova, Liubov I.; Dilman, Alexander D.. The article conveys some information:

Photochem. organocatalytic substitution of pyridylthio group in alkyl tetrafluoropyridinyl thioethers RS-4-C5F4N with bis(catecholato)diboron followed by treatment with pinacol and triethylamine affording pinacol boronic esters RBpin is described. The reaction is promoted by an organic photocatalyst, 2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile (3DPA2FBN) under irradiation with 400 nm light, and works with primary, secondary, and tertiary sulfides. The electron depleting character of the fluorinated pyridine fragment plays an important role in generating alkyl radicals. In the experiment, the researchers used many compounds, for example, 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Safety of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cao, Guang-Mei; Hu, Xin-Long; Liao, Li-Li; Yan, Si-Shun; Song, Lei; Chruma, Jason J.; Gong, Li; Yu, Da-Gang published their research in Nature Communications on December 31 ,2021. The article was titled 《Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2》.Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile The article contains the following contents:

Herein, a strategy for visible-light photoredox-catalyzed umpolung carboxylation of diverse carbonyl compounds with CO2 by using Lewis acidic chlorosilanes as activating/protecting groups was reported. This strategy was general and practical to generate valuable α-hydroxycarboxylic acids. It works well for challenging alkyl aryl ketones and aryl aldehydes, as well as for α-ketoamides and α-ketoesters, the latter two of which have never been successfully applied in umpolung carboxylations with CO2 (to the best of our knowledge). This reaction features high selectivity, broad substrate scope, good functional group tolerance, mild reaction conditions and facile derivations of products to bioactive compounds, including oxypheonium, mepenzolate bromide, benactyzine and tiotropium. Moreover, the formation of carbon radicals and carbanions as well as the key role of chlorosilanes are supported by control experiments After reading the article, we found that the author used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Application In Synthesis of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
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《Organophotoredox-Catalyzed Reductive Tetrafluoroalkylation of Alkenes》 was published in Journal of Organic Chemistry in . These research results belong to Kostromitin, Vladislav S.; Levin, Vitalij V.; Dilman, Alexander D.. Electric Literature of C43H30F2N4 The article mentions the following:

A method for the hydroperfluoroalkylation of alkenes with 1,2-dibromotetrafluoroethane leading to tetrafluorinated bromides is described. The reaction is conveniently performed under blue light irradiation using an organic photocatalyst and ascorbic acid as a reducing agent. Primary products can be further functionalized via radical pathways affording various tetrafluorinated compounds The experimental part of the paper was very detailed, including the reaction process of 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Electric Literature of C43H30F2N4)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Electric Literature of C43H30F2N4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Computed Properties of C43H30F2N4On October 11, 2020 ,《Photocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction》 was published in Chemistry – A European Journal. The article was written by Donabauer, Karsten; Murugesan, Kathiravan; Rozman, Ursa; Crespi, Stefano; Koenig, Burkhard. The article contains the following contents:

A photocatalytic approach to the Corey-Seebach reaction has been described. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) catalysis. This catalytic merger allows a C-H to carbanion activation by the abstraction of a hydrogen atom followed by radical reduction The generated nucleophilic intermediate is then capable of adding to carbonyl electrophiles. By this approach, dithianes I (R1 = Me, NCCH2CH2, PhCH2CH2, etc.) were reacted with various aldehydes and ketones R2C(O)R3 [R2 = Et, i-Pr, MeSCH2CH2, R3 = H; R2 = n-Pr, i-Pr, PhCH2CH2, etc., R3 = Me; R2R3 = (CH2)3, (CH2)2O(CH2)2, etc.] giving access to the valuable α-hydroxy dithianes II. The proposed reaction mechanism is supported by emission quenching, radical-radical homocoupling and deuterium labeling studies as well as by calculated redox-potentials and bond strengths. In the experiment, the researchers used 2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9Computed Properties of C43H30F2N4)

2,4,6-Tris(diphenylamino)-3,5-difluorobenzonitrile(cas: 1403850-00-9) is cyanoarene-based donor-acceptor photocatalyst developed by the Zeitler group. While this catalyst has a balanced redox profile, allowing for its use in a variety of transformations, it stands out as the most reducing catalyst of the family.Computed Properties of C43H30F2N4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts