Category: 1365531-89-0

Electric Literature of C48H52O4P2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-2,2′-Bis[bis(3,5-dimethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy-)-1,1′-biphenyl, is researched, Molecular C48H52O4P2, CAS is 1365531-89-0, about Biaryl diphosphine ligands and their ruthenium complexes: Preparation and use for catalytic hydrogenation of ketones. Author is Lorraine, Shannen; Abdur-Rashid, Kamaluddin; Jia, Wenli; Abdur-Rashid, Kareem; Maragh, Paul; Dasgupta, Tara.

Procedures for the preparation of the nucleophilic diphosphine ligands (R)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine) ((R)-Ph-Garphos) and (S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine) ((S)-Ph-Garphos) were described. The ligands were used to prepare the ruthenium(II) Ph-Garphos complexes, chloro(p-cymene)(R)-(4,4′,6,6′-tetraamethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Ph-Garphos]Cl (3)) and chloro(p-cymene)(S)-(4,4′,6,6′-tetraamethoxybiphenyl-2,2′-diyl)bis(diphenylphosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Ph-Garphos]Cl (4)). In the presence of the chiral diamine co-ligands (1R,2R)-1,2-diphenylethane-1,2-diamine (R,R-DPEN) and (1S,2S)-1,2-diphenylethane-1,2-diamine (S,S-DPEN), complexes 3 and 4 were found to be catalyst precursors for the enantioselective reduction of aryl ketones under mild conditions (room temperature and 3-4 atm of H2). The chiral alcs. were isolated in moderate to good yields and with enantioselectivities of up to 93%. The ruthenium complexes chloro(p-cymene)(R)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(R)-Xyl-Garphos]Cl (5)) and chloro(p-cymene)(S)-(4,4′,6,6′-tetramethoxybiphenyl-2,2′-diyl)bis(bis(3,5-dimethylphenyl)-phosphine)ruthenium(II) chloride ([RuCl(p-cymene)(S)-Xyl-Garphos]Cl (6)) were also prepared and used as catalyst precursors for the hydrogenation of aryl ketones in the presence of (R,R)-DPEN and (S,S)-DPEN. Significant improvements in the enantioselectivities of the alcs. (up to 98% ee.) were afforded. A combination of 6 and (S,S)-DPEN afforded (R)-1-(3-methoxyphenyl)ethanol in 89% yield and with 95% ee which was shown to be a suitable precursor for the preparation of (S)-rivastigmine.

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1365531-89-0, is researched, Molecular C48H52O4P2, about Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides, the main research direction is catalytic asym conjugate addition thiolactam unsaturated thioamide; soft Lewis acid hard Bronsted base cooperative catalysis.SDS of cas: 1365531-89-0.

Direct catalytic asym. conjugate addition of thiolactams to α,β-unsaturated thioamides was efficiently promoted by a soft Lewis acid/hard Bronsted base cooperative catalyst in a highly stereocontrolled manner [e.g., I + II → III (anti/syn 97/3, >99% ee of anti)]. Thioamide functionality was crucial to promote both the efficient enolization of thiolactam pronucleophiles and the subsequent stereoselective conjugate addition to α,β-unsaturated thioamides. Differential manipulation of the two thioamide functionalities of the product highlights the synthetic utility of the present catalytic system.

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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (R)-2,2′-Bis[bis(3,5-dimethylphenyl)phosphino]-4,4′,6,6′-tetramethoxy-)-1,1′-biphenyl, is researched, Molecular C48H52O4P2, CAS is 1365531-89-0, about Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration.Synthetic Route of C48H52O4P2.

1,4-Migrations of organopalladium and organorhodium species have been utilized for the development of various cascade reactions involving remote C-H bond activation. Recently, we reported a cobalt-catalyzed migratory arylzincation reaction of an alkyne that features alkenyl-to-aryl 1,4-cobalt migration and cobalt-to-zinc transmetalation as key steps. We report herein that the cobalt/arylzinc combination can also promote a cascade arylative cyclization reaction of alkynes bearing pendant ester or ketone moieties to afford benzo-fused cyclic ketone or alc. products, resp. The reaction is considered to proceed through insertion of the alkyne into an arylcobalt species, 1,4-cobalt migration, and intramol. organocobalt addition to the carbonyl group. The present cobalt/arylzinc system may not only serve as an alternative to previously reported rhodium/arylboron and iridium/arylboron systems but also complement their scopes in the arylative cyclization.

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Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts