Kaufmann, Julia; Jaeckel, Elisabeth; Haak, Edgar published the artcile< Ruthenium-catalyzed formation of pyrazoles or 3-hydroxynitriles from propargyl alcohols and hydrazines>, Reference of 13635-04-6, the main research area is pyrazole regioselective preparation; hydroxynitrile preparation; propargyl alc hydrazine cascade ruthenium catalyst.
Functionalized pyrazoles I [R = 3-Me, 3-Ph, 5-Me, 5-styryl, etc.] were generated from secondary propargyl alcs. and hydrazines in a ruthenium-catalyzed cascade process, consisting of redox isomerization, Michael addition, cyclocondensation and dehydrogenation steps. The same bifunctional catalyst mediated conversion of tertiary propargyl alcs. with hydrazine to 3-hydroxynitriles II [R1 = Me; R2 = Me, Et, vinyl, etc.] via anti-Markovnikov hydroamination followed by elimination of ammonia was also shown.
ARKIVOC (Gainesville, FL, United States) published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 13635-04-6 belongs to class nitriles-buliding-blocks, and the molecular formula is C5H9NO, Reference of 13635-04-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts