Category: 135048-32-7

Somawardhana, C. W. published the artcileRadiopharmaceutical for differential diagnosis of tuberculoma: synthesis of carbon-11 labeled 2-[¹¹C]cyanoisonicotinic acid hydrazide, Application In Synthesis of 135048-32-7, the publication is Applied Radiation and Isotopes (1991), 42(6), 559-62, database is CAplus.

The radiochem. synthesis of 2-[¹¹C]cyanoisonicotinic acid hydrazide (I) was accomplished. Carbon-11 cyano group was introduced at the 2-position of the pyridine ring of 1-methoxy-4-methoxycarbonyl pyridinium Me sulfate via a Reissert-Kaufmann type reaction. The reaction was performed on a solid support (silica gel) to yield no-carrier-added Me 2-[¹¹C]cyano-isonicotinate in (32.4%) yield. This method is unique for the incorporation of [¹¹C]HCN to base sensitive substrates. The carbon-11-labeled Me ester was treated with hydrazine to give I. The final radiochem. yield was 10% and the synthesis time was approx. 35 min.

Applied Radiation and Isotopes published new progress about 135048-32-7. 135048-32-7 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Nitrile,Hydrazine,Amine,Hydrazide,Amide, name is 2-Cyanoisonicotinohydrazide, and the molecular formula is C9H10O4, Application In Synthesis of 135048-32-7.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sato, Takahiro published the artcileDiscovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia, HPLC of Formula: 135048-32-7, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(21), 6225-6229, database is CAplus and MEDLINE.

A previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. A series of 3,5-dipyridyl-1,2,4-triazole derivatives were synthesized and their in vivo activity in lowering the serum uric acid levels in rats was examined As a result, 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (FYX-051) to be one of the most potent XOR inhibitors; it exhibited an extremely potent in vivo activity, weak CYP3A4-inhibitory activity and a better pharmacokinetic profile than the previously identified compound FYX-051 is currently being evaluated in a phase 2 clin. trial.

Bioorganic & Medicinal Chemistry Letters published new progress about 135048-32-7. 135048-32-7 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Nitrile,Hydrazine,Amine,Hydrazide,Amide, name is 2-Cyanoisonicotinohydrazide, and the molecular formula is C7H6N4O, HPLC of Formula: 135048-32-7.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Sato, Takahiro published the artcileDiscovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia. [Erratum to document cited in CA152:037497], Application In Synthesis of 135048-32-7, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2390, database is CAplus.

The title should read: “Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 – a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia”. The compound name needs to be corrected throughout the article. On page 6225, the chem. name for Compound 2 is incorrect and should read: ‘2-[2-(2-methoxyethoxy)ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]benzonitrile. On page 6225, the chem. name for compound 39 should read: ‘3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole. On page 6228, the compound in line 25 should read: “2-methyl-4-pyridyltriazole”.

Bioorganic & Medicinal Chemistry Letters published new progress about 135048-32-7. 135048-32-7 belongs to nitriles-buliding-blocks, auxiliary class Pyridine,Nitrile,Hydrazine,Amine,Hydrazide,Amide, name is 2-Cyanoisonicotinohydrazide, and the molecular formula is C7H6N4O, Application In Synthesis of 135048-32-7.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts