1349718-98-4, name is 2,4-Dichloro-6-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1349718-98-4
To a solution of 2,4-dichloro-6-fluorobenzonitrile (3.87 mmol) in 15 mL THF was added a solution of BH3 (15.5 mmol, 1M in THF) and the mixture was stirred at 60 C. for 1 h. After cooling to 0 C., water was added followed by MeOH and the mixture was then heated to 70 C. for 10 min. The solvent was evaporated, the residue was taken up in water and EtOAc. The aqueous phase was separated, basified with 1M NaOH and it was extracted 3 times with EtOAc. The combined organic layers were dried over MgSO4 and concentrated in vacuo to obtain the desired product as yellow oil. LC-MS (A): tR=0.39 min; [M+CH3CN+H]+: 234.90.
The synthetic route of 1349718-98-4 has been constantly updated, and we look forward to future research findings.