Category: 134450-56-9

Synthetic Route of 134450-56-9,Some common heterocyclic compound, 134450-56-9, name is 4,5-Difluorophthalonitrile, molecular formula is C8H2F2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Difluorophthalonitrile (30 g, 183 mmol) was added to 1-chloronaphthalene (150 ml) in which BCl3 (14 g, 120 mmol) was dissolved, and the mixture was heated to reflux under a nitrogen atmosphere. Afier cooling, the mixture was separated and purified by silica chromatography, and then a product was purified by sublimation and purification to obtain F6-SubPc-Cl (11 g, yield 34%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,5-Difluorophthalonitrile, its application will become more common.

Reference:
Patent; SONY SEMICONDUCTOR SOLUTIONS CORPORATION; OBANA, Yoshiaki; NEGISHI, Yuki; HASEGAWA, Yuta; TAKEMURA, Ichiro; ENOKI, Osamu; MOGI, Hideaki; MATSUZAWA, Nobuyuki; (67 pag.)US2017/54089; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 134450-56-9 as follows. category: nitriles-buliding-blocks

1 mmol of the starting material CN-1-1, 3.0 mmol of potassium carbonate and 2.5 mmol of the starting material F-8-2, Was added to 10 mL of dimethylsulfoxide and heated at 150 C for 8 hours. After cooling to room temperature, 200 mL of water was added to the system to precipitate a solid which was purged and purified by column chromatography to give a solid.

According to the analysis of related databases, 134450-56-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ruisheng Optoelectric Science And Technology (Changzhou) Co., Ltd.; Huang Da; Cao Chenhui; Xie Zaifeng; Ma Tengda; (39 pag.)CN107011243; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 134450-56-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 134450-56-9, name is 4,5-Difluorophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Type (1-1) synthetic method of compound structure shown in the: lower range of the nitrogen, the 4,5-difluoro -1,2-dicyanobenzene is hydrogenated (5mmol), phenoxazine (18mmol), Pd2(dba)3(0.8mmol), NaOtBu (30mmol) and tBu3P·HBF4(0.8mmol) into 100 ml dimethyl formamide in the DMF 80 C temperature under stirring overnight. The 10 ml in cold water is added to the mixture the reaction quenching. After cooling to room temperature to be mixture, by vacuum filtration, then through the column chromatography purification product type (1-1), the product is dried in a vacuum. Yield: 69%.

The chemical industry reduces the impact on the environment during synthesis 4,5-Difluorophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Photoelectric Co. Ltd. Kunshan States; duan, lian; zhang, yun ge; liu, song; Zhao, lei; (18 pag.)CN105418533; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 134450-56-9, The chemical industry reduces the impact on the environment during synthesis 134450-56-9, name is 4,5-Difluorophthalonitrile, I believe this compound will play a more active role in future production and life.

A solution of 5a (67 mg, 0.61 mmols) in DMF (10 mL) was treated NaH (60 %, 48mg, 1.2 mmols), allowed to stir for half a minute at room temperature followed by addition of phthalonitrile 6 (100 mg, 0.61 mmols). A deep blue coloration developed in the reaction flask and TLC monitoring in 10 minutes showed complete consumption of both starting materials 5a and 6 and appearance of a new spot more non-polar to both starting materials, which was very strongly UV-active. The reaction was quenched in cold water (100 mL), extracted into ethyl acetate (20 mL), organic layer repeatedly washed with brine solution (5 × 15 mL) and dried over sodium sulfate. Evaporation of the majority of ethyl acetate followed by re-crystallization in an ice-bath yielded 7a (single spot by TLC control, 30% Ethyl acetate/Petroleum ether) as buff-colored crystals. Yield (62 mg, 43%). 1H NMR (300 MHz, d6-DMSO): delta 7.82 (s, 2H), 7.05 (s, 4H); 13C NMR (150 MHz, d6-DMSO): delta 145.57, 140.06, 125.67, 121.99, 116.76, 115.27, 110.81; UV-vis (DMSO) lambdamax (log epsilon) 261 (4.53), 324 (3.48); HRMS (ESI+) calcd. for C14H6N2O2Na 257.0327, observed for C14H6N2O2Na 257.0293. Melting point: 311 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluorophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Banerjee, Subhadeep; Chattopadhyay, Anjan; Banerjee, Arnab; Haridas, Meera; Saini, Praveen; Das, Moitreyi; Majik, Mahesh S.; Maurya, Yogesh Kr.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 4; (2015); p. 753 – 757;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 134450-56-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 134450-56-9, name is 4,5-Difluorophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of compound of formula XVIII is illustrated in Scheme 3 below. (0146) Reaction of 0.5 molar equivalents of carbazole with 4,5-difluorophthalonitrile affords compound 8 which is then reacted with 4 to provide intermediate 9. Hydrolysis of the nitrile functions provides dicarboxylic acid 10 on acidification. Methylation with iodomethane and anion metathesis with saturated NH4PF6 solution provides the product XVIII.

The chemical industry reduces the impact on the environment during synthesis 4,5-Difluorophthalonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS; Zysman-Colman, Eli; Wong, Michael Yin; (41 pag.)US2017/352818; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 134450-56-9,Some common heterocyclic compound, 134450-56-9, name is 4,5-Difluorophthalonitrile, molecular formula is C8H2F2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Difluorophthalonitrile (30 g, 183 mmol) was added to 1-chloronaphthalene (150 ml) in which BCl3 (14 g, 120 mmol) was dissolved, and the mixture was heated to reflux under a nitrogen atmosphere. Afier cooling, the mixture was separated and purified by silica chromatography, and then a product was purified by sublimation and purification to obtain F6-SubPc-Cl (11 g, yield 34%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,5-Difluorophthalonitrile, its application will become more common.

Reference:
Patent; SONY SEMICONDUCTOR SOLUTIONS CORPORATION; OBANA, Yoshiaki; NEGISHI, Yuki; HASEGAWA, Yuta; TAKEMURA, Ichiro; ENOKI, Osamu; MOGI, Hideaki; MATSUZAWA, Nobuyuki; (67 pag.)US2017/54089; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 134450-56-9 as follows. Application In Synthesis of 4,5-Difluorophthalonitrile

Compounds 5 and 6 were synthesized by reacting 4 with sub-stoichiometric or stoichiometric 4,5-difluorophthalonitrile, respectively, under basic conditions via nucleophilic aromatic substitution reaction. The targeted charged TADF emitters XI and XII were obtained following methylation with iodomethane and anion metathesis with saturated NH4PF6 solution in 33% and 27% yield, respectively, over six steps. The solubilities of XI and XII in DCM were greatly improved after the anion metathesis, in comparison with that of the original iodo salts.

According to the analysis of related databases, 134450-56-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS; Zysman-Colman, Eli; Wong, Michael Yin; (41 pag.)US2017/352818; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

134450-56-9, name is 4,5-Difluorophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 134450-56-9

1.52 g (9.14 mmol) 9H-carbazole and 1.91 g (13.7 mol)of potassium carbonate were placed in a 50-mE recovery flask, and the interior of the flask was substituted with nitrogen. 15 mE of dimethylsulfoxide was added to themixture, which was stirred under a nitrogen stream at room temperature for 1 hout 0.500 g (3.05 mmol) of 4,5-difluo- rophthalonitrile was added to the mixture. The mixture was stirred under a nitrogen stream at room temperature for 3 hours and then at 500 C. for 20 hours. Thereafier, the mixturewas added to water, followed by stirring. The mixture was extracted with toluene. After the extraction, the extracted solution was rinsed with a saturated sodium chlorine aqueous solution. After rinsing, an organic layer and an aqueous layer were separated, and the organic layer was dried byadding magnesium sulfate thereto. After drying, the mixture was suction-filtered to provide a filtrate. The resulting filtrate was concentrated to provide a solid matter, which was purified by silica gel column chromatography. In the purification, a mixed solvent of toluene and hexane (1/4) was firstly used as a developing solvent, then a mixed solvent of toluene and hexane (7/3) was used, and then toluene was used as a developing solvent (the developing ratio was gradually changed). The resulting fraction was concentratedto provide a solid matter, which was then rinsed by reslurrywith a mixed solvent of acetone and methanol, therebyproviding a pale yellow powdered solid matter in a yieldamount of 1.20 g and a yield of 85.8%.

The synthetic route of 134450-56-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KYULUX, INC.; Adachi, Chihaya; Uoyama, Hiroki; Nomura, Hiroko; Goushi, Kenichi; Yasuda, Takuma; Kondo, Ryosuke; Shizu, Katsuyuki; Nakanotani, Hajime; Nishide, Jyunichi; (83 pag.)US9502668; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 134450-56-9, These common heterocyclic compound, 134450-56-9, name is 4,5-Difluorophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 5a (67 mg, 0.61 mmols) in DMF (10 mL) was treated NaH (60 %, 48mg, 1.2 mmols), allowed to stir for half a minute at room temperature followed by addition of phthalonitrile 6 (100 mg, 0.61 mmols). A deep blue coloration developed in the reaction flask and TLC monitoring in 10 minutes showed complete consumption of both starting materials 5a and 6 and appearance of a new spot more non-polar to both starting materials, which was very strongly UV-active. The reaction was quenched in cold water (100 mL), extracted into ethyl acetate (20 mL), organic layer repeatedly washed with brine solution (5 × 15 mL) and dried over sodium sulfate. Evaporation of the majority of ethyl acetate followed by re-crystallization in an ice-bath yielded 7a (single spot by TLC control, 30% Ethyl acetate/Petroleum ether) as buff-colored crystals. Yield (62 mg, 43%). 1H NMR (300 MHz, d6-DMSO): delta 7.82 (s, 2H), 7.05 (s, 4H); 13C NMR (150 MHz, d6-DMSO): delta 145.57, 140.06, 125.67, 121.99, 116.76, 115.27, 110.81; UV-vis (DMSO) lambdamax (log epsilon) 261 (4.53), 324 (3.48); HRMS (ESI+) calcd. for C14H6N2O2Na 257.0327, observed for C14H6N2O2Na 257.0293. Melting point: 311 C.

Statistics shows that 4,5-Difluorophthalonitrile is playing an increasingly important role. we look forward to future research findings about 134450-56-9.

Reference of 134450-56-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 134450-56-9 as follows.

Under nitrogen atmosphere, 16.2 g of the intermediate (D), 4.92 g of 4.5-difluorophthalonitrile, 9.12 g ofpotassium carbonate, 120 mL of N-methyl-2-pyrrolidinone were put into a flask and stirred at the room temperature for 10 hours. Water was added to the reaction solution. The obtained solution was filtered to obtain a deposited solid. The obtained deposited solid was washed with toluene, whereby 3.25 g (yield 17%) of a yellow solid of the compound 4 was obtained.

According to the analysis of related databases, 134450-56-9, the application of this compound in the production field has become more and more popular.