Category: 134227-45-5

A common heterocyclic compound, 134227-45-5, name is 3,4,5-Trifluorobenzonitrile, molecular formula is C7H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 134227-45-5.

To N, N- dimethylformamide (10mL) solution of 3,4,5-trifluorobenzonitrile (305mg), phenol (213mg), cesium carbonate (760mg) were added,and the mixture was stirred for 3 h at 80 . Aftercooling the reaction mixture to room temperature, water was added, and themixture was extracted with ethyl acetate. The combined organic layerswere washed with saturated brine, dried over anhydrous magnesium sulfate, andconcentrated under reduced pressure. The resulting residue was purified bysilica gel column chromatography (eluent: ethyl acetate / heptane = 1/10), toobtain the desired product (387mg).

The synthetic route of 3,4,5-Trifluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISHIHARA SANGYO KAISHA LIMITED; TSUKUDA, SHINTARO; IWAMOTO, TAKUYA; MORIYAMA, TAICHI; (45 pag.)JP2016/56117; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 134227-45-5, name is 3,4,5-Trifluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 134227-45-5

Example 177A 3,5-difluoro-4-(4-morpholinyl)benzylamine The title compound was prepared using the procedures described in Examples 172A and 172B using 3,4,5-trifluorobenzonitrile instead of 4-fluorobenzonitrile.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 134227-45-5.

Reference:
Patent; Lee, Chih-Hung; Bayburt, Erol K.; DiDomenico JR., Stanley; Drizin, Irene; Gomtsyan, Arthur R.; Koenig, John R.; Perner, Richard J.; Schmidt JR., Robert G.; Turner, Sean C.; White, Tammie K.; Zheng, Guo Zhu; US2004/157849; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts