Category: 13388-75-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H11NO2

To a stirred solution of 5 (2.0 g, 11.28 mmol) in dry CH2CI2 (125 mL), at -78C, under an argon atmosphere, was added boron tribromide (3.75 mL, 39.48 mmol). Following the addition, the reaction mixture was gradually warmed to room temperature and the stirring was continued at that temperature until completion of the reaction (2 days). The reaction mixture was then poured into a mixture of aqueous saturated NaHC03/crushed ice. The mixture was warmed to room temperature and volatiles were removed in vacuo. The residue was diluted with ethyl acetate and washed with saturated NaHCOs solution, water and brine. The organic layer was dried (MgSC^), filtered and concentrated under reduced pressure. Purification by flash column chromatography on silica gel (40% ethyl acetate in hexanes) afforded 1.42 g (85% yield) of 10 as a white solid, mp 144-146C. 1H NMR (500 MHz, CDCl3/DMSO-d6) delta 8.69 (s, 2H, OH), 6.34 (m, 1H, 2-H), 6.33 (m, 2H, 4-H, 6-H), 3.59 (s, 2H, -CH2CN).

According to the analysis of related databases, 13388-75-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NORTHEASTERN UNIVERSITY; MAKRIYANNIS, Alexandros; D’SOUZA, Marsha, R.; BAJAJ, Shama; NIKAS, Spyridon, P.; THAKUR, Ganeshsingh, A.; WO2014/62965; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 13388-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Preparation of (2Z)-2-(3,5-dimethoxyphenyl)-3-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile 5.0 g (20.0 mmol) of 4-[(8-hydroxyoctyl)oxy]benzaldehyde, 3.5 g (19.8 mmol) of 3,5-(dimethoxyphenyl)acetonitrile are dissolved in 50 mL of propan-2-ol. The solution is heated to 60 C. and 2.0 mL (2.0 mmol) of a one molar solution of tetrabuthylamoniumhydroxyde in methanol are added drop wise. After 2 h at 60 C., the reaction mixture is cooled to 0 C. The precipitate is filtered off, washed with cold propan-2-ol and recristalized in propan-2-ol. 3.5 g of (2Z)-2-(3,5-dimethoxyphenyl)-3-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile are obtained as a white solid (42% yield). This material proves chromatographically homogenous and displays spectral characteristics consistent with its assigned structure. 1H NMR DMSO-d6 300 MHz: 7.99 (s, 1H), 7.94 (d, 2H), 7.09 (d, 2H), 6.86 (d, 2H), 6.56 (t, 1H), 4.32 (t, 1H), 4.05 (t, 2H), 3.81 (s, 6H), 3.37 (q, 2H), 1.73 (qi, 2H), 1.43-1.29 (m, 10H)

The synthetic route of 2-(3,5-Dimethoxyphenyl)acetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ROLIC AG; Lincker, Frederic; Bury S. Pires, Izabela; Chappellet, Sabrina; Scandiucci De Freitas, Patricia; Ibn-Elhaj, Mohammed; Tang, Qian; Palika, Satish; Hoshino, Masato; Eckert, Jean-Francois; (61 pag.)US9366906; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

According to the analysis of related databases, 13388-75-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 13388-75-5,Some common heterocyclic compound, 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, molecular formula is C10H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

The synthetic route of 13388-75-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 13388-75-5

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13388-75-5.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 13388-75-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

The chemical industry reduces the impact on the environment during synthesis 2-(3,5-Dimethoxyphenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 13388-75-5, The chemical industry reduces the impact on the environment during synthesis 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, I believe this compound will play a more active role in future production and life.

2-(3,5-dimethoxyphenyl)acetonitrile (100 g, 564 mmol, Eq: 1.00) was disolved in THF (500 mL). The solution was cooled to 0C and iodomethane (324 g, 142 mL, 2.26 mol, Eq: 4.0) was added. 1 M Potassium tert-butoxide solution in THF (1.69 L, 1.69 mol, Eq: 3) was added dropwise at 0C-2C over 60 min (conversion > 99% by GC after end addition). After 1 h at 0C, the reaction mixture was added to a stirred mixture of MTBE (1.5 L) and water (750 mL). The organic phase was separated, washed twice with 25% aqueous NaCl (750 mL), dried over Na2S04, filtered and concentrated under reduced pressure to give 115.8 g of the title compound as an oil (98.5a% by GC).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3,5-Dimethoxyphenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 13388-75-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 13388-75-5 as follows.

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

According to the analysis of related databases, 13388-75-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C10H11NO2

General procedure: A 50 mL round-bottomed flask was charged with 3 (0.177 g, 1 mmol), aromatic aldehyde or substituted aromatic aldehyde (1 mmol) and 10 mL methanol with stirring, and the mixture was heated to 60 C. After 30 min, sodium methoxide (0.027 g, 0.5 mmol) was added to the mixture and keep the temperature for 4-6 h. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to RT, and the precipitate was separated by filter and recrystallized from methanol to give 4a-4z and 5a-5d.

The synthetic route of 13388-75-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ma, Jun; Li, Jiajun; Tian, Yu-Shun; Bioorganic and Medicinal Chemistry Letters; vol. 27; 1; (2017); p. 81 – 85;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-(3,5-Dimethoxyphenyl)acetonitrile

A mixture of 3,5-dimethoxyphenyl acetonitrile (10 g, 56.43 mmol) and methyl iodide (10.5 mL) in anhydrous DMF (280 mL) under an argon atmosphere was added dropwise (via cannula) to a solution of sodium hydride (4.06 g, 169.20 mmol) in 30 mL DMF at 0C. The mixture was warmed to room temperature and stirred for 1.5 hours. Upon completion, the reaction mixture was quenched by the addition of saturated aqueous NH4C1 and diluted with diethyl ether. The organic layer was separated and the aqueous phase was extracted with diethyl ether. The combined organic layer was washed with brine and dried (MgS04) and the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography on silica gel (10-30% ethyl acetate in hexanes) to afford 11.3 g (98% yield) of compound 6 as a viscous oil. 1H NMR (500 MHz, CDC13) delta 6.61 (d, J= 2.0 Hz, 2H, 2-H, 6-H, ArH), 6.27 (t, J= 2.0 Hz, 1H, 4-H, ArH), 3.81 (s, 6H, OMe), 1.70 (s, 6H, C(C)2C).

The synthetic route of 13388-75-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTHEASTERN UNIVERSITY; MAKRIYANNIS, Alexandros; D’SOUZA, Marsha, R.; BAJAJ, Shama; NIKAS, Spyridon, P.; THAKUR, Ganeshsingh, A.; WO2014/62965; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts