Category: 13338-63-1

13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3,4,5-Trimethoxyphenylacetonitrile

General procedure: To a mixture of DBU (20 mol%) in DMSO (4 mL) were added 2 (1.5 equiv) and benzyl cyanide (50 mg, 1 equiv). The reaction mixture was stirred at r.t. for 3 h. Then, aq NH4Cl was added dropwise. H2O and EtOAc were added and the phases were separated. The aqueous layer was extracted with EtOAc. The organic phase was dried (MgSO4) and filtered. The solvent was evaporated under reduced pressure to give an oil, which was purified by column chromatography. The solvent polarity was increased via a gradient from neat petroleum ether (PE) to a mixture of EtOAc/PE (Table 1).

The synthetic route of 13338-63-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Campos, Joana F.; Queiroz, Maria-Joao R. P.; Berteina-Raboin, Sabine; Synthesis; vol. 50; 5; (2018); p. 1159 – 1165;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 13338-63-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Using the method of synthesizing an intermediate similar to that of Example 1,Take 3,4,5-trimethoxyphenylacetonitrile (5) 0.01 mol, 0.01 mol of 3-fluorobenzaldehyde and 20 mL of methanol into a 50 mL three-necked flask.Stirring to 60 C, adding 0.005 mol of sodium methoxide, constant temperature reaction 4-6 h,TLC scanning and detection, after the reaction is completed, it is cooled to room temperature, filtered, washed with water, dried, and recrystallized from methanol to obtain a pale yellow solid.Yield: 40.4%,

The chemical industry reduces the impact on the environment during synthesis 3,4,5-Trimethoxyphenylacetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yanbian University; Bu Gonggaofamingren; (14 pag.)CN108503561; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 13338-63-1, The chemical industry reduces the impact on the environment during synthesis 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, I believe this compound will play a more active role in future production and life.

Using the method of synthesizing an intermediate similar to that in Example 1, 0.01 mol of 3,4,5-trimethoxyphenylacetonitrile (5),0.01 mol of 4-fluorobenzaldehyde and 20 mL of methanol into a 50 mL three-necked flask, stirring and heating to 60 C, adding 0.005 mol of sodium methoxide, and reacting at a constant temperature for 4-6 h.TLC scanning and detection, after the reaction is completed, it is cooled to room temperature, filtered, washed with water, dried, and recrystallized from methanol to obtain a pale yellow solid.Yield: 73.9%,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trimethoxyphenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yanbian University; Bu Gonggaofamingren; (14 pag.)CN108503561; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13338-63-1, Quality Control of 3,4,5-Trimethoxyphenylacetonitrile

Using the method of synthesizing an intermediate similar to that of Example 1, Take 0.193 g (0.01 mol) of 2-(3,4,5-trimethoxyphenyl)acetonitrile (5), 0.156 g (0.01 mol) of 2-naphthaldehyde, and 20 mL of methanol into a 50 mL three-necked flask. Stirring to 60 C, adding sodium methoxide 0.027 g (0.005 mol), Constant temperature reaction for about 5h, thin layer chromatography to follow the reaction, After the reaction is completed, cool to room temperature, filter, and wash. Dry and recrystallize from methanol to give a pale yellow solid. Yield: 40.6%,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,4,5-Trimethoxyphenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yanbian University; Tian Yushun; Li Jiajun; Ma Jun; (19 pag.)CN109384689; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 13338-63-1, A common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, molecular formula is C11H13NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method 1: Under a nitrogen atmosphere, in a glove box, Add 0.02 mmol of Pd2(dba)3·HCCl3 (tris(dibenzylideneacetone)dipalladium·chloroform), 0.04 mmol of tBuDavePhos. (2-di-tert-butylphosphonium-2-(N,N-dimethylamino)biphenyl) or 2-di-tert-butylphosphine-2′-(N,N-dimethylamino)-1,1′-biphenyl, 0.52 mmol of diphenylphosphine oxide, 1.5 equivalents of t-BuOK (potassium tert-butoxide), Adding to the Schlenk reaction tube in turn, then adding 0.4 mmol of 3,4,5-trimethoxybenzyl nitrile compound, vacuuming and backfilling with nitrogen; Under a nitrogen atmosphere, a solvent of 3 ml of 1,4-dioxane was added, and the reaction was continued at 120 C for 16 h. After the reaction is completed, it is cooled to room temperature and separated by column chromatography. The target product was obtained: 3,4,5-trimethoxybenzyldiphenylphosphine oxide in a yield of 96%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Hunan University; Zhang Jishu; Qi Tafamingrenqingqiubugongkaixingming; (13 pag.)CN109438512; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 13338-63-1,Some common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, molecular formula is C11H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The solution of NaOH (2.71g, 67.93mmol) in water (20mL) was added at room temperature to the solution of polymethoxyphenylacetonitrile [40] (5.0g, 33.96mmol) and hydroxylamine hydrochloride (4.72g, 67.93mmol) in EtOH (100mL). The reaction mixture was refluxed for 5h, the solvent was evaporated in vacuo, and the residue was washed by water (3×30mL) and dried. Yield 75-80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5-Trimethoxyphenylacetonitrile, its application will become more common.

Synthetic Route of 13338-63-1,Some common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, molecular formula is C11H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: the aromatic carbaldehyde (1 mole) and the appropriate substituted phenylacetonitrile (1.1 mol equiv) were added to 5% sodium methoxide in methanol and the mixture was stirred at reflux temperaturefor 2-3 h. The resulting solid was filtered off, washed with water, and finally washed with cold methanol. The obtained crude solid was recrystallized from methanol to afford the desired product as a pure crystalline solid. The characterization data for the active compounds is given in reference section.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5-Trimethoxyphenylacetonitrile, its application will become more common.

Electric Literature of 13338-63-1, These common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Using the method of synthesizing an intermediate similar to that of Example 1,Take 0.01 mol of 3,4,5-trimethoxyphenylacetonitrile (5), 0.01 mol of 4-chlorobenzaldehyde and 20 mL of methanol into a 50 mL three-necked flask.Stirring to 60 C, adding 0.005 mol of sodium methoxide, constant temperature reaction 4-6 h,TLC scanning and detection, after the reaction is completed, it is cooled to room temperature, filtered, washed with water, dried, and recrystallized from methanol to obtain a pale yellow solid.Yield: 59.3%,

Statistics shows that 3,4,5-Trimethoxyphenylacetonitrile is playing an increasingly important role. we look forward to future research findings about 13338-63-1.

Reference:
Patent; Yanbian University; Bu Gonggaofamingren; (14 pag.)CN108503561; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C11H13NO3

Following procedures similar to that of Step D but substituting 3,4,5-trimethoxyphenylacetonitrile for 3-methoxy-5-(methylthio)-4-propoxyphenylacetonitrile, there was prepared ethyl 3,4,5,-trimethoxy-alpha-cyanobenzeneacetate in 89% yield as a clear oil. NMR (CDCl3): delta 1.35 (t, 3H, -CO2CH2C H 3), 4.25 (q, 2H, -CO2C H 2CH3), 4.65 (s, 1H, -C H (CN)CO2Et), 6.05 (s, 2H, Ar-H).

The synthetic route of 3,4,5-Trimethoxyphenylacetonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck & Co., Inc.; EP257921; (1988); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 13338-63-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Using the method of synthesizing an intermediate similar to that in Example 1, 0.01 mol of 3,4,5-trimethoxyphenylacetonitrile (5),0.01 mol of 2-chlorobenzaldehyde and 20 mL of methanol into a 50 mL three-necked flask, stirring and heating to 60 C, adding 0.005 mol of sodium methoxide, and reacting at a constant temperature for 4-6 h.TLC scanning and detection, after the reaction is completed, it is cooled to room temperature, filtered, washed with water, dried, and recrystallized from methanol to obtain a pale yellow solid. Yield: 76.2%,

The chemical industry reduces the impact on the environment during synthesis 3,4,5-Trimethoxyphenylacetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yanbian University; Bu Gonggaofamingren; (14 pag.)CN108503561; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts