Category: 127946-77-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Amino-1-cyclopropanecarbonitrile hydrochloride

The carboxylate (1 g, 1.82 mmol) and 1-amino-1-cyclopropanecarbonitrNe hydrochloride (0.2 16 g, 1.82 mmol) was suspended in DMAC (5 ml) and the stirred suspension was cooled down to 3C and then HATU (0.83 g, 2.2 mmol) was slowly added. The reaction mixture was then stirred for 15 mm and then dilsopropylethytamine (DIEA, I ml, 5.5 mrriol) was added. The mixture was stirred at 5C for another 4 hours (check by TLC 50/1 chloroform/methanol), then at -5C for 3 hours. The reaction was terminated by slow dropwiso addition of water (6 ml) at 5C and the suspension was stirred for 1 hour more. The precipitate was isolated by filtration and washed with a mixture of DMAC-H20 (10 ml – 10 ml) and dried in vacuo (180 mbar) at 45C. A white crystalline product of 0.66 g was obtained (84%, HPLC 91. 00%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 127946-77-4.

Reference:
Patent; ZENTIVA, K.S.; BABIAK, Peter; ZEZULA, Josef; (12 pag.)WO2016/95879; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, Recommanded Product: 127946-77-4

Example 2; Synthesis of N-(1-cyanocyclopropyl)-2(S)-(1-benzenesulfonyliminoethylamino)-3 -(1-methyl-cyclohexyl)propionamide; (table 2, cpd 19); Step 1; To a stirred solution of 2S-fc^butoxycarbonylamino-3-(l-methylcyclohexyl)propionicacid (283 rng, 1.0 mmol) (prepared as described in Reference H except utilizing 1-methylcyclohexanol intead of 1-methylcyclopentanol) and 1-aminocyclopropanecarbonitrileHC1 salt (178 mg, 1.5 mmol) in DMF (5 mL) at room temperature was added HATU (418 mg,1.1 mmol), followed by diisopropyl ethylamine (0.87 mL, 5 mmol). After being stirred at roomtemperature overnight, the reaction mixture was concentrated under reduced pressure and thenpartitioned between ethyl acetate and brine. The combined organic extracts were dried (MgSCX),concentrated under reduced pressure, and the residue was purified by flash chromatography onsilica gel (eluted with 1: 2 EtOAc/ hexanes) to yield [l-(l-cyanocyclopropylcarbamoyl)-25′-(l-methylcyclohexyl)ethyl]-carbamic acid tert-butyl ester (315 mg, 90%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AXYS PHARMACEUTICALS; WO2004/108661; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, name: 1-Amino-1-cyclopropanecarbonitrile hydrochloride

To a two-necked flask was added 1-((tert-butoxycarbonyl) amino) cyclohexanecarboxylic acid (301 mg, 1.24 mmol)1-amino-1-cyclopropyl cyanide hydrochloride (294 mg, 2.48 mmol) HATU (471 mg, 1.24 mmol) and DMF (6 mL), nitrogen protection, at 0C, triethylamine (0.52 mL, 3.72 mmol) was added, the reaction was stirred at 0C for 4 hours. Water (50 mL) was added to the reaction system, extracted with ethyl acetate (50 mL x2) combined organic phase, the organic phase was washed with saturated brine (50 mL x 2) dried over anhydrous sodium sulfate. Filtration, evaporation of the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (petroleum ether / ethyl acetate (V / V) = 8/1), the title compound was obtained as a white solid (0.34 g, 90%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Dongguan Dongyangguang Pharmaceutical Research And Development Co., Ltd.; Zhou Pingjian; Wang Xiaojun; Yang Chuanwen; Lin Jihua; Cao Shengtian; Yang Xinye; Zhang Yingjun; (33 pag.)CN106928113; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, A new synthetic method of this compound is introduced below., Quality Control of 1-Amino-1-cyclopropanecarbonitrile hydrochloride

A solution of 2-[3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5- dihydro- 1 H- 1 ,2,4-triazol- 1 -yl } methyl)- IH- 1 ,2,4-triazol- 1 -yl]pyridine-3-carboxylic acid (Example 33A, 80.0 mg, 157 muiotaetaomicron) in N,N-dimethylformamide (1.0 ml) was treated with HATU (89.5 mg, 235 muiotaetaomicron) and stirred 30 min at room temperature. 1-Aminocyclopropanecarbonitrile hydrochloride (1: 1) (27.9 mg, 235 muiotaetaomicron) was then added followed by and N,N- diisopropylethylamine (120 mu, 710 mumol). The resulting mixture was stirred 2 h at room temperature. Purification by preparative HPLC (Method 4) afforded 72.0 mg (80 % of th.) of the title compound. LC-MS (Method 2): Rt = 1.60 min; MS (ESIpos): m/z = 574.1 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm] : 9.23 (d, 2H), 8.64 (dd, IH), 8.08 (dd, IH), 7.83-7.53 (m, 5H), 6.92 (d, IH), 5.08 (s, 2H), 4.41-4.21 (m, IH), 4.08-3.75 (m, 2H), 1.60-1.11 (m, 4H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; WITTWER, Matthias, Beat; LUSTIG, Klemens; TINEL, Hanna; LINDNER, Niels; SCHIRMER, Heiko; (449 pag.)WO2019/81307; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

(3R,4R)-N-( 1 -Cyanocyclopropyl)-4-(5 -(4-( 1,1 -dioxidothiomorpholino)phenyl)-2-(5 – fluoropyridin-3 -yl)thiazol-4-yl)bicyclo [4.1 . 0]heptane-3 -carboxamide was synthesized following the same procedure as in Step H of Example 1 using (3R,4R)-4-(5-(4-(1,1- dioxidothiomorpholino)phenyl)-2-(5 -fluoropyridin-3 -yl)thiazol-4-yl)bicyclo [4.1 . 0]heptane-3 -carboxylic acid (0.180 g, 0.340 mmol, 1.00 equiv), DMF (5 mL), 1- aminocyclopropanecarbonitrile hydrochloride (0.202 g, 1.70 mmol, 5.00 equiv), HATU (0.324 g, 0.850 mmol, 2.50 equiv) and DIPEA (0.330 g, 2.55 mmol, 7.48 equiv). This resulted in 0.135 g (67%) of (3R,4R)-N-( 1 -Cyanocyclopropyl)-4-(5 -(4-( 1,1 -dioxidothiomorpholino)phenyl)-2-(5 – fluoropyridin-3-yl)thiazol-4-yl)bicyclo[4. 1 .0]heptane-3-carboxamide as a yellow solid: MS (ES,m/z): 592.1 (M + 1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn; PAONE, Daniel, V.; LI, Jing; GINNETTI, Anthony; LIM, John; FU, Jianmin; XU, Shimin; WO2015/54038; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 127946-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The carboxylic acid 5A (195 mg, 0.5 mmol), 1-aminocyclopropanecarbonitrile hydrochloride (65.2 mg, 550 muiotaetaomicron), HATU (380 mg, 1.00 mmol) and ethyldiisopropyl amine (262 mu, 1.5 mmol) were dissolved in acetonitrile (10 mL) and stirred at room temperature over night. The reaction was concentrated under reduced pressure. The residue was diluted with 5% aquous sodium carbonate solution and extracted twice with ethyl acetate. The combined organic layers were washed withlM aqueous hydrogen chloride solution and with saturated aqueous sodium chloride solution, dried over Na2S04, filtered and concentrated under reduced pressure to yield (2S,4R)-iert-butyl 4-(2- chlorophenylsulfonyl)-2-( 1 -cyanocyclopropylcarbamoyl)-pyrrolidine- 1 -carboxylate 6H as a yellow oil (66 %). MS ISP (m/e): 354.2 (100) [(M-BOC+H)]+, 398.1 (25) [(M- Isobutylene+H)]+, 454.1 (12) [(M+H)]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BANNER, David; HAAP, Wolfgang; LUEBBERS, Thomas; PETERS, Jens-Uwe; WO2013/120921; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 127946-77-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of (S)-2-((ieri-butoxycarbonyl)amino)-3-(3-chloro-4-(trifluoromethoxy)- phenyl)propanoic acid (example la; 3.52 g, 9.17 mmol, Eq: 1) in DMF (40 ml) 1- aminocyclopropanecarbonitrile hydrochloride (1.31 g, 11 mmol, Eq: 1.2), HATU (6.98 g, 18.3 mmol, Eq: 2) and /Pr2Net (4.15 g, 5.61 ml, 32.1 mmol, Eq: 3.5) were added at 0 C under an Argon atmosphere. The mixture was stirred for 3h, during that time to the mixture was warmed up to 25 C. After that the mixture was diluted with EtOAc. The organic phase was extracted with water (2x) and brine (3x), dried over Na2S04, filtered, and evaporated to dryness. The mixture was purified by flash chromatography (Si02; CH2Cl2/EtOAc, gradient from 100:0 to 0: 100 within 40 min) to yield the title compound (3.14 g; 76.4%) as a yellow solid. MS (ESI): m/z = 446.1 [M-H] .

The synthetic route of 1-Amino-1-cyclopropanecarbonitrile hydrochloride has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GIROUD, Maude; HAAP, Wolfgang; KUHN, Bernd; MARTIN, Rainer E.; (75 pag.)WO2017/89389; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 127946-77-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127946-77-4 name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-bromo-1-(4-fluorophenyl)ethanone (3.0 g, 13.82 mmol) and DIPEA (7.24 mL, 41.5 mmol) in NMP (55.3 mL) was added 1-aminocyclopropanecarbonitrile, HCl (1.859 g, 15.20 mmol) and the reaction mixture was stirred overnight at RT. Since the starting material was not completely consumed, the mixture was heated in an oil-bath at 70 C. for 1 h, cooled to RT, diluted with water and extracted with EtOAc (2¡Á50 mL). The combined organic layers were washed with brine and dried over anhydrous MgSO4, filtered. The filtrate was concentrated under reduced pressure (water-bath temp.25 C.) and the residue was purified by silica gel chromatography (40 g RediSep column, eluting with 30% EtOAc in hexanes). Fractions containing the product were combined and evaporated to afford intermediate 188A? (1.66 g, 54.97% yield) as an oil. MS (ES): m/z=219.15 [M+H]+; HPLC Ret. Time min. 2.903 (HPLC Method E).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company; Kinsella, Todd; Gelman, Marina; Hong, Hui; Darwish, Ihab S.; Singh, Rajinder; Yu, Jiaxin; Borzilleri, Robert M.; Velaparthi, Upender; Liu, Peiying; Darne, Chetan; Rahaman, Hasibur; Warrier, Jayakumar Sankara; (311 pag.)US2016/257690; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 127946-77-4 name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 127946-77-4

(3R,4R)-N-( 1 -Cyanocyclopropyl)-4-(5 -(4-( 1,1 -dioxidothiomorpholino)phenyl)-2-(5 – fluoropyridin-3 -yl)thiazol-4-yl)bicyclo [4.1 . 0]heptane-3 -carboxamide was synthesized following the same procedure as in Step H of Example 1 using (3R,4R)-4-(5-(4-(1,1- dioxidothiomorpholino)phenyl)-2-(5 -fluoropyridin-3 -yl)thiazol-4-yl)bicyclo [4.1 . 0]heptane-3 -carboxylic acid (0.180 g, 0.340 mmol, 1.00 equiv), DMF (5 mL), 1- aminocyclopropanecarbonitrile hydrochloride (0.202 g, 1.70 mmol, 5.00 equiv), HATU (0.324 g, 0.850 mmol, 2.50 equiv) and DIPEA (0.330 g, 2.55 mmol, 7.48 equiv). This resulted in 0.135 g (67%) of (3R,4R)-N-( 1 -Cyanocyclopropyl)-4-(5 -(4-( 1,1 -dioxidothiomorpholino)phenyl)-2-(5 – fluoropyridin-3-yl)thiazol-4-yl)bicyclo[4. 1 .0]heptane-3-carboxamide as a yellow solid: MS (ES,m/z): 592.1 (M + 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Amino-1-cyclopropanecarbonitrile hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn; PAONE, Daniel, V.; LI, Jing; GINNETTI, Anthony; LIM, John; FU, Jianmin; XU, Shimin; WO2015/54038; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

127946-77-4, Name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, 127946-77-4, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of example 9a) (850 mg, 2.74 mmol, Eq: 1.00), 1-aminocyclopropane- carbonitrile hydrochloride (422 mg, 3.56 mmol, Eq: 1.30), sodium 2-ethylhexanoate (705 mg, 4.24 mmol, Eq: 1.55) in water (3 ml) and THF (2.00 ml) was stuffed at 55 C for 18 h. To the reaction mixture were added hydrochloric acid (189 mg, 157 tl, 1.91 mmol, Eq:0.70) and sodium chloride (1.36 g, 1.36 ml, 23.3 mmol, Eq: 8.50). The mixture was stuffed for 15 mm, then poured into AcOEt (25 ml) and extracted. The aqueous layer was back- extracted with AcOEt (3 x 20 ml). The organic layers were dried over Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 40 g, 0% to 90% EtOAc in heptane) to yield the title compound as white foam (560 mg;52 %). mlz = 393.0 [M+Hf?.

Statistics shows that 1-Amino-1-cyclopropanecarbonitrile hydrochloride is playing an increasingly important role. we look forward to future research findings about 127946-77-4.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ANSELM, Lilli; BANNER, David; HAAP, Wolfgang; KUHN, Bernd; LUEBBERS, Thomas; PETERS, Jens-Uwe; SPINNLER, Beat; WO2014/29722; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts