Adding a certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4, Product Details of 127946-77-4
To prepare (2S,4R)-4-[2-chloro-4-((5)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide, example 183c (200 mg) was dissolved in DMF (2.0 mL). HATU (420 mg), DIEA (143 mg) and 1-amino-1-cyclopropane carbonitrile hydrochloride were added to the solution. The obtained suspension was stirred at ambient temperature for 2 h. After that the solvent was evaporated under reduced pressure to dryness. The residue was dissolved in CH2Cl2 (25 ml), was extracted in succession with aqueous 0.5 NHCl-solution, aqueous 10% Na2CO3-solution and brine. The water layers were washed with totally CH2Cl2 (50 ml), the combined organic layers were dried over Na2SO4, filtered and evaporated. The residue was purified over silica gel chromatography with n-heptan: AcOEt to yield 130 mg (59%) of the title compound as colorless amorphous solid. MS (ESI): m/z=602.1 [M+H]+.
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Reference:
Patent; Sanchez, Ruben Alvarez; Banner, David; Ceccarelli, Simona M.; Grether, Uwe; Haap, Wolfgang; Hartman, Peter; Hartmann, Guido; Hilpert, Hans; Kuehne, Holger; Mauser, Harald; Plancher, Jean-Marc; US2010/267722; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts