Category: 127667-01-0

Adding a certain compound to certain chemical reactions, such as: 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127667-01-0, name: 2-Fluoro-5-methoxybenzonitrile

11 g of 2-fluoro-5-methoxybenzonitrile was added to a mixed solvent of 200 ml of methanol and 100 ml of water, and 9 g of hydroxylamine hydrochloride and 12 g of anhydrous sodium acetate were added. The reaction was heated under reflux for 12 hours, and water and ethyl acetate were added thereto. The solution was separated by extraction, and the organic layer was collected, dried and concentrated. The residue was separated on a silica gel column to obtain 9 g of 2-fluoro-N’-hydroxy-5-methoxybenzylhydrazone.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Bu Gonggaofamingren; (6 pag.)CN107698535; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 127667-01-0

Synthesis of methyl 2-fluoro-5-hydroxybenzoate 2-Fluoro-5-methoxybenzonitrile (3d, purchased from Alfa Aesar) (5 g, 33 mmol) was dissolved in hydrobromic acid (50 mL) and glacial acetic acid (30 mL), refluxed for 28 hours at 140 C., and then the reaction mixture was diluted with 100 mL ethyl acetate. The reaction mixture was then washed with 50 mL water and saturated sodium chloride solution successively for three times. The organic layers were combined and concentrated to give a crude product of 2-fluoro-5-hydroxybenzoic acid (3e), 2.88 g white solid (yield 56%). 1H NMR (600 MHz, DMSO-d6) delta 7.19-7.17 (m, 1H), 7.08-7.04 (m, 1H), 6.95-6.92 (m, 1H); ESI-MS m/z: calculated for 156.02. found 154.91 [M-H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CHENGDU DI’AO PHARMACEUTICAL GROUP CO., LTD.; Ji, Jianxin; Guo, Na; Xue, Ting; Kang, Bingqiang; Ye, Xinfa; Chen, Xin; Zhang, Tao; US2015/51211; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 127667-01-0, These common heterocyclic compound, 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

11 g of 2-fluoro-5-methoxybenzonitrile was added to a mixed solvent of 200 ml of methanol and 100 ml of water. Further, 9 g of hydroxylamine hydrochloride and 12 g of anhydrous sodium acetate were added, and the reaction was stirred under reflux for 12 hours. Add water and ethyl acetate, extract the liquid, collect the organic phase, dry, concentrate, The residue was separated on a silica gel column to obtain 9 g of 2-fluoro-N’-hydroxy-5-methoxybenzidine.

The synthetic route of 127667-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Deng Zeping; (6 pag.)CN108129415; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 127667-01-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 127667-01-0 as follows.

Preparation 27 5- Meth lox -1 /-/-indazol-3-amine 5-(Methyloxy)-1 H-indazol-3-amine: 2-Fluoro-5-(methyloxy)benzonitrile (5 g, 33.1 mmol) was dissolved in 1 -Butanol (50 mL), and hydrazine hydrate (20.61 mL, 662 mmol) was added. The reaction mixture was heated at 150 C for 48 hours then it was cooled to rt, diluted with water, and extracted with EtOAc (2×100 mL). The organic layer was washed with brine, dried over Na2S04 and concentrated under vacuum to give the title compound (2 g, 37%). 1H NMR (400 MHz, DMSO-cf6) delta ppm 3.75 (s, 3 H) 5.17 (s, 0 H) 6.89 (dd, J=9.03, 2.51 Hz, 0 H) 7.09 – 7.22 (m, 1 H) 1 1.18 (br. s., 7 H); MS (m/z) 164 (M+H+).

According to the analysis of related databases, 127667-01-0, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 127667-01-0

2-Fluoro-5-methoxy benzonitrile (70 mg, 0.46 mmol, 1.0 equiv.) and hydrazine monohydrate (0.3 ml, 6.0 mmol, 13.0 equiv.) were mixed in n-BuOH (2 ml) and heated the reaction mixture in a microwave oven at 180 0C for 45 mins. After it cooled to room temperature, the product indazole amine was precipitated (purified) by addition of n-hexane or n-heptane solvent. Further the precipitated solid was purified using MeOH: CH2Cl2 (1 :1) solvent. The solid was washed with little water (to remove the excess hydrazine), and was dried for couple of hours to obtain nice crystalline white solid of indazole amine (46 mg) in 60 % yield. HPLC: Shim-pack VP ODS 4.6 x 50 m column, Water: MeOH; 0.1% TFA, RT =1.38; LC-MS; M+H+ = 164.2.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/89307; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127667-01-0, name: 2-Fluoro-5-methoxybenzonitrile

A mixture of 4-chloro-5-methyl-lH-pyrazole-3- carboxylic acid dibutylamide (1.5 g, 5.5 mmol), 2-fluoro-5-methoxybenzonitrile (1.1 g, 7.2 mmol), and cesium carbonate (1.8 g, 5.5 mmol) in dimethylformamide (5 mL) was microwaved at 130C for 30 minutes. The solvent was removed in vacuo. The crude material was eluted through a silica gel column with a 0 to 70% ethyl acetate / heptane gradient to afford the title compound (1.3 g, 59% yield) as a white solid. MS (ESI) [m/e, (M+H)+] = 403.5. NMR (400 MHz, chloroform-d) delta ppm 7.32 (d, J=8.5 Hz, 1 H), 7.18 – 7.22 (m, 1 H), 7.12 – 7.18 (m, 1 H), 3.84 (s, 3 H), 3.41 – 3.51 (m, 2 H), 3.32 – 3.41 (m, 2 H), 2.15 (s, 3 H), 1.54 – 1.66 (m, 2 H), 1.48 (qd, J=7.7, 7.5 Hz, 2 H), 1.26 – 1.40 (m, 2 H), 1.17 (ddd, J=14.9, 7.4, 7.3 Hz, 2 H), 0.89 (t, J=7.3 Hz, 3 H), 0.77 (t, J=7.3 Hz, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; NOVARTIS AG; VISSER, Michael Scott; YUSUFF, Naeem; WO2013/96049; (2013); A1;; ; Patent; NOVARTIS AG; FORD, Daniel; PORTER, John Robert; VISSER, Michael Scott; YUSUFF, Naeem; WO2013/96060; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 127667-01-0, name is 2-Fluoro-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127667-01-0, 127667-01-0

To a solution of 2-fluoro-5-methoxybenzonitrile (2 g, 13.2 mmoi) in DMSO (6.6 mL) was added l 02 (1.6 mL) and K2C03 (274 mg, 1.98 mmoi). The resulting solution was stirred for 30 mm at it. The reaction was then quenched with NaHC03 (said, 30 mL). The resulting solution was extracted with EtO Ac (50 mL), and the organic layers were combined, and concentrated under reduced pressure. The residue was purified by flash column chromatography (0-10% EtO Ac/petroleum ether) on silica gel to obtain compound 36a as a white solid. ^I-NM (400 MHz, DMSQ-t delta (ppm): 7.66 – 7.70 (m, 2H), 7.04 – 7.23 (m, 3H), 3.77 (s, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-5-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HUANG, Hui; MEEGALLA, Sanath; PLAYER, Mark R.; (219 pag.)WO2017/27309; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts