Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127666-99-3, name is 2-Chloro-4-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H6ClNO
A mixture of tris(dibenzylideneacetone)dipalladium (33 mg, 0.0357 mmol) and tricyclohexylphosphine (47 mg, 0167 mmol) in anhydrous dioxane (2.5 mL) was stirred for 30 min at room temperature under an atmosphere of argon. 4,4,4′,4′,5,5,5′,5′-Octamethyl- 2,2′-bi-l,3,2-dioxaborolane (333 mg, 1.31 mmol) potassium acetate (175 mg, 1.785 mmol) and a solution of 2-chloro-4-methoxybenzonitrile (200 mg, 1.19 mmol) in anhydrous dioxane (2.5 mL) were sequentially added and the resulting mixture was irradiated in a microwave at 120 0C for 15 h. Concentration of the reaction mixture and purification by column chromatography, using a gradient of 0-30 % ethyl acetate in heptane as the eluent, gave 238 mg (77% yield) of the title compound: 1H NMR (CDCl3) delta 7.63 (d, J= 8.6 Hz, 1
According to the analysis of related databases, 127666-99-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2008/76046; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts