Adding a certain compound to certain chemical reactions, such as: 127510-95-6, name is Methyl 2-cyano-5-methoxybenzoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127510-95-6, COA of Formula: C10H9NO3
5′-Methoxy-spiro[cyclopropane-11 ‘-isoindol]-3′(2’H)-one5 To a flask containing 2-Cyano-5-methoxy-benzoic acid methyl ester (10.22 g, 53.4 mmol), titanium (IV) isopropoxide (17 g, 61 mmol) and diethyl ether (200 mL) was added a solution of 3 M ethyl magnesium bromide in diethyl ether (36 mL, 107 mmol) at 0 “C. The mixture was allowed to warm to room temperature over 3 hours upon which an aqueous solution of 1 N HCI (200 mL) was slowly added. The black mixture was filtered through 400 g Q of celite and the filtrate was concentrated and absorbed onto silica in order to perform chromatography (0-100 % ethyl acetate: hexanes) to yield 5′-Methoxy-spiro[cyclopropane-11’- isoindol]-3′(2’H)-one (3.9 g, 38 %) MS: ES M+1 190.1 (189.2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyano-5-methoxybenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/20306; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts