Potential local anaesthetics. III. Basic N-(ring substituted 浼?浼?dialkylbenzyl)acylamines was written by Lindberg, Ulf H.;Jakupovic, Edib;Nylen, Betty;Ulff, Bengt;Akerman, Bengt. And the article was included in Acta Pharmaceutica Suecica in 1970.Reference of 5351-07-5 This article mentions the following:
I were prepared by the method of Lindberg, et al. (1969), by treating the appropriate benzyl cyanide with an alkyl iodide and sodium amide, hydrolysis and then the Hofmann reaction to the amine followed by treatment with a haloacyl halide and then treatment with an amine. I were generally less effective anesthetics than lidocaine. N-(4-Chloro-浼?浼?dimethylbenzyl)-2-piperidinoacetamide (I, R = Me, R1 = H, NR2R3 = piperidino), as compared to prilocaine, was an effective surface anesthetic agent, while N-(4-chloro-浼?浼?dimethylbenzyl)-2-diethylaminopropionamide was as effective as a low-toxic injection anesthetic. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Reference of 5351-07-5).
2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Reference of 5351-07-5
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts