O’Hara, Fionn; Blackmond, Donna G.; Baran, Phil S. published their research in Journal of the American Chemical Society on August 14 ,2013. The article was titled 《Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability》.Electric Literature of C7H2ClF3N2 The article contains the following contents:
Radical addition processes can be ideally suited for the direct functionalization of heteroaromatic bases, yet these processes are only sparsely used due to the perception of poor or unreliable control of regiochem. A systematic investigation of factors affecting the regiochem. of radical functionalization of heterocycles using alkylsulfinate salts revealed that certain types of substituents exert consistent and additive effects on the regioselectivity of substitution. This allowed us to establish guidelines for predicting regioselectivity on complex π-deficient heteroarenes, including pyridines, pyrimidines, pyridazines, and pyrazines. Since the relative contribution from opposing directing factors was dependent on solvent and pH, it was sometimes possible to tune the regiochem. to a desired result by modifying reaction conditions. This methodol. was applied to the direct, regioselective introduction of iso-Pr groups into complex, biol. active mols., such as diflufenican (I; R = H → R = iso-Pr) and nevirapine (II; R = H → R = iso-Pr). In the experimental materials used by the author, we found 6-Chloro-2-(trifluoromethyl)nicotinonitrile(cas: 1245913-20-5Electric Literature of C7H2ClF3N2)
6-Chloro-2-(trifluoromethyl)nicotinonitrile(cas: 1245913-20-5) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Electric Literature of C7H2ClF3N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts