Category: 123257-07-8

Synthesis of 2-methylpyrrolo[1,2-a]pyrazin-1(2H)-one was written by Brimble, Margaret A.;Brimble, Mark T.;Hodges, Richard;Lane, Geoffrey A.. And the article was included in Australian Journal of Chemistry in 1988.SDS of cas: 123257-07-8 The following contents are mentioned in the article:

The synthesis of 2-methylpyrrolo[1,2-α]pyrazin-1(2H)-one (I) present in the insect feeding deterrent peramine through oxidation of the saturated lactam is described. The preparation of the related 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one (II) through a Lewis-acid-catalyzed cyclization of the amide acetal III is also described. This study involved multiple reactions and reactants, such as Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8SDS of cas: 123257-07-8).

Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.SDS of cas: 123257-07-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis and anti-inflammatory and analgesic activities of dihydropyrrolo[1,2-a]pyrazin-1-one was written by Pang, Jiyan;Sun, Guang;Fu, Decai;Sun, Shoufang. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2002.Recommanded Product: 123257-07-8 The following contents are mentioned in the article:

The structure-activity relationship (SAR) of the title compounds was studied to search for new anti-inflammatory and analgesic agents. 6-(R-carbonyl)-2-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ones (R = R’- Ph, R”-benzyl, or phenylethenyl; R’ = H, 4-Cl, 2-Cl, 2,4- dichloro, 4-Me, 4-Br, 4-F, 2-F, 4-methoxy, or 4-nitro; R” = H or Cl) were designed based on the known SAR. The 3,4-dihydropyrrolo[1,2-a]pyrazin-1-one moiety (II) was prepared from Me 2-pyrrolecarboxylate by N-alkylation, reduction, and cyclization. The Friedel-Crafts reaction of compound II with acyl chloride afforded the 6-aroyl derivatives The anti-inflammatory and analgesic activities were tested in mice. Thirteen of 6-aroyl-2-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ones were synthesized. Most of the compounds showed remarkable anti-inflammatory and/or analgesic activities in mice. The activities of one compound (R = 4-chlorophenyl) were equal to those of ibuprofen. This study involved multiple reactions and reactants, such as Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8Recommanded Product: 123257-07-8).

Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 123257-07-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts