Category: 1211596-75-6

Application of 1211596-75-6, The chemical industry reduces the impact on the environment during synthesis 1211596-75-6, name is Methyl 2-cyano-3-(trifluoromethyl)benzoate, I believe this compound will play a more active role in future production and life.

Reference Example 6 Synthesis of 2-cyano-3-(trifluoromethyl)benzoic acid In accordance with the manner of Reference Example 5, the title compound was obtained from 248 mg of methyl 2-cyano-3-(trifluoromethyl)benzoic acid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyano-3-(trifluoromethyl)benzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP2017279; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1211596-75-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1211596-75-6 as follows.

Step 4: 2-(Hydroxymethyl)-6-(trifluoromethyl)benzonitrile To a solution of LiBH4 (3.3 g, 153 mmol) in THF (100 mL) was added methyl 2-cyano-3- (trifluoromethyl)benzoate (14 g, 61 mmol). The mixture was stirred at room temperature for 2 h. The mixture was concentrated in vacuo to give the crude product, which was diluted with water, and extracted with EtOAc. The organic layer was separated, dried over Na2S04, filtered, and concentrated to give the crude product 2-(hydroxymethyl)-6- (trifluoromethyl)benzonitrile (10 g, 77% yield): 1H NMR (400 MHz, CDC13) delta 7.83-7.72 (m, 3H), 5.46 (s, 2H); ES-LCMS m/z 202.1 (M+H).

According to the analysis of related databases, 1211596-75-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; KEENAN, Richard, M.; MILLER, Aaron, Bayne; QIN, Donghui; WO2013/177349; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts