Category: 120351-94-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-(2-Aminoethoxy)benzonitrile

Step 1 Synthesis of N-[2-(3-cyanophenoxy)ethyl]bromoacetamide: 1.50 g (9.26 mmol) of 3-(2-aminoethoxy)benzonitrile and 1.77 ml (10.2 mmol) of diisopropylethylamine were dissolved in 15 ml of tetrahydrofuran. A solution of 0.92 ml (11.1 mmol) of bromoacetyl chloride in 5 ml of tetrahydrofuran was added to the obtained solution at 0C, and they were stirred for 8 hours. The solvent was evaporated, and the residue was purified by the silica gel column chromatography to obtain the title compound: Yield: 2.18 g (7.73 mmol) (83 %) MS (ESI, m/z) 305 (M+Na+) H-NMR (CDCl3) delta 3.76(2H, dt), 3.98 (2H, d), 4.08(2H, t), 7.14 (1H, dd),7.16 (1H, s), 7.28 (1H, dd), 7.39 (1H, td)

The synthetic route of 120351-94-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3-(2-Aminoethoxy)benzonitrile

Step 3 Synthesis of t-butyl 4-[4-[N-[2-(3-cyanophenoxy)ethyl]carbamoyl]benzenesulfonyl]piperazine-1-carboxylate: 1.41 g (3.79 mmol) of t-butyl (4-carboxybenzenesulfonyl)piperazine-1-carboxylate was stirred in dimethylformamide. 1.3 ml (9.25 mmol) of triethylamine and 0.38 ml (3.95 mmol) of ethyl chloroformate were added to the resultant mixture. After stirring for 5 minutes followed by the addition of 1.02 g (4.61 mmol) of 3-(2-aminoethoxy)benzonitrile, the temperature was elevated to room temperature and they were stirred for 2 hours. After the dilution with 1 N hydrochloric acid and extraction with ethyl acetate, the product was treated in an ordinary manner to obtain the title compound. Yield: 1.88 g (3.66 mmol) (97 %) MS (ESI, m/z) 537 (M+Na+) H-NMR (CDCl3) delta 1.40 (9H, s), 2.97 (4H, t), 3.49 (4H, t), 3.91 (2H, dd), 4.19 (2H, t), 7.03 (1H, t), 7.14 (1H, d), 7.17 (1H, s), 7.27 (1H, d), 7.38 (1H, d), 7.78 (2H, d), 7.98 (2H, d)

The synthetic route of 3-(2-Aminoethoxy)benzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C9H10N2O

Step 1 Synthesis of N-[2-(3-cyanophenoxy)ethyl]-(1S)-10-camphorsulfonamide: 700 mg (4.32 mmol) of 3-(2-aminoethoxy)benzonitrile was dissolved in 20 ml of DMF. 0.75 ml (4.32 mmol) of diisopropylethylamine and a solution of 1.08 g (4.32 mmol) of (1S)-(+)-10-camphorsulfonyl chloride in 5 ml of DMF were added to the solution at 0C, and they were stirred for 4 hours. The crude product was obtained by the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant. After the purification by the silica gel column chromatography, the title compound was obtained. Yield: 1.41 g (3.75 mmol) (87 %) MS (ESI, m/z) 377 (MH+) H-NMR (CDCl3) delta 0.88 (3H, s), 1.04 (3H, s) 1.47 (1H, ddd), 1.89-2.15(5H, m), 2.33 (1H, td), 2.98 (1H, d), 3.46 (1H, d), 3.59 (2H, dt), 4.14 (2H, t), 6.00(1H, t), 7.15 (1H, d), 7.18(1H, s), 7.26 (1H, d), 7.39 (1H,t)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 120351-94-2,Some common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 Synthesis of N-[2-(3-cyanophenoxy)ethyl]-(1R)-10-camphorsulfonamide: The title compound was obtained from 700 mg (4.32 mmol) of 3-(2-aminoethoxy)benzonitrile and 1.08 g (4.32 mmol) of (1R)-(-)-10-camphorsulfonyl chloride in the same manner as that of step 1 in Example 106. Yield: 1.33 g (3.54 mmol) (82 %) MS (ESI, m/z) 377 (MH+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(2-Aminoethoxy)benzonitrile, its application will become more common.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 3-(2-Aminoethoxy)benzonitrile

Example 27 Synthesis of N-[2-(3-amidinophenoxy)ethyl]-3-(2-aminoethoxy)benzamidine tristrifluoroacetate: 10 ml of ethanol containing 30 % (w/v) of hydrogen chloride was added to 1.75 g (8.84 mmol) of 3-(2-aminoethoxy)benzonitrile, and the resultant mixture was stirred at room temperature for 22 hours. The solvent was evaporated under reduced pressure, and the residue was dissolved in 10 ml of 10 % (w/v) solution of ammonia in ethanol. The obtained solution was stirred at room temperature for 31 hours. The solvent was evaporated, and the obtained residue was purified by the reversed-phase high-performance liquid chromatography with silica gel, containing octadodecyl group chemically bonded thereto, as the filler. After the elution with a mixed solvent of water and acetonitrile containing 0.1 % (v/v) of trifluoroacetic acid, the fraction of the intended product was freeze-dried to obtain the title compound. Yield: 134 mg (0.195 mmol) (2.2 %). MS (ESI, m/z) 342 (MH+) H-NMR (DMSO-d6) delta 3.20-3.23 (2H, m), 3.81-3.85 (2H, t), 4.24 (2H, dd), 4.38 (2H, dd), 7.25-7.40 (4H, m), 7.50-7.60 (4H, m), 8.18 (2H, brs), 9.60 (4H, t).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 120351-94-2, its application will become more common.

Some common heterocyclic compound, 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, molecular formula is C9H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 120351-94-2

Step 1 Synthesis of 3-[2-(2-naphthalenesulfonylamino)ethoxy]benzonitrile: 163 mg of 3-(2-aminoethoxy)benzonitrile and 0.5 ml of diisopropylethylamine were dissolved in 10 ml of dimethylformamide. A solution of 250 mg (1.1 mmol) of 2-naphthalenesulfonyl chloride in dimethylformamide was added to the obtained solution under cooling with ice, and they were stirred under cooling with ice for 2 hours. The title compound was obtained by the same isolation process as that of step 1 in Example 1 with ethyl acetate as the extractant. Yield: 320 mg (0.91 mmol) (91 %) H-NMR (CDCl3) delta 3.45 (2H, dt), 4.00(2H, t), 5.05(1H, br), 6.96 (1H, s),6.97 (1H, d), 7.20 (1H, d), 7.30 (1H, t), 7.59-7.70 (2H, m), 7.82-7.98(4H, m), 8.46 (1H, s)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 120351-94-2, its application will become more common.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120351-94-2 as follows. name: 3-(2-Aminoethoxy)benzonitrile

Step 1: To a solution of 3-(2-aminoethoxy)benzonitrile (276 mg, 1 mmol, 1.0 equiv) in 5 mL of methanol at room temperature was added TEA (630 muL, 4.5 equiv) and 4-bromophthalic anhydride (227 mg, 1.0 equiv). After stirring at room temperature for 3 h, the solvent was evaporated and the residue was vacuum dried. The residue in 10 mL of pyridine was then treated with 12 mL of acetic anhydride at room temperature overnight. The volatile solvent was evaporated, and the residue was taken up with EtOAc, washed with H2O, dried over MgSO4 and column purified with 1:3 EtOAc/hexanes on silica gel to give 3-[2-(5-bromo-1,3-dioxoisoindolin-2-yl)ethoxy]benzonitrile in 84% yield. LRMS found for C17H12BrN2O3 (M+H)+: 371.05.

According to the analysis of related databases, 120351-94-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2003/114448; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 120351-94-2, name is 3-(2-Aminoethoxy)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H10N2O

Step 4 Synthesis of N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamide: 1.13 g (7.68 mmol) of 4-cyanobenzoic acid and 1.6 ml (14.1 mmol) of N-methylmorpholine were dissolved in 30 ml of dimethylformamide. 0.67 ml (7.05 mmol) of ethyl chloroformate was added to the solution under cooling with ice/water. After stirring for 5 minutes, 1.27 g (6.41 mmol) of 3-(2-aminoethoxy)benzonitrile was added to the reaction mixture, and the obtained mixture was stirred at room temperature for one hour. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained. Yield: 1.29 g (4.43 mmol) (69 %). MS (FAB, m/z) 292 (MH+) H-NMR (CDCl3) delta 3.91 (2H, dt), 4.19 (2H, t), 6.78 (1H, br), 7.14 (1H, d), 7.17 (1H, s), 7.28 (1H, d), 7.39 (1H, t), 7.75 (2H, d), 7.90 (2H, d)

According to the analysis of related databases, 120351-94-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ajinomoto Co., Inc.; EP976722; (2000); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts