Category: 119584-73-5

Hynes, John B. published the artcileDirect synthesis of 2,4-diaminoquinazolines from 2-fluorobenzonitriles, Category: nitriles-buliding-blocks, the main research area is quinazoline diamino derivative preparation; diaminoquinazoline derivative preparation; difluorobenzonitrile cyclocondensation guanidine carbonate; fluorobenzonitrile cyclocondensation guanidine carbonate.

In a search for new methods for preparing 2,4-diaminoquinazolines I (R = 5-F, 5-Cl, 5-Br, 5-I, 6-F, 7-F, 8-F, 5-OMe, 5-SMe, 5-NMe2, 5,6,7,8-F4) it was found that the reaction of 2,6-difluorobenzonitrile with guanidine carbonate gave 2,4-diamino-5-fluoroquinazoline (I; R = 5-F) in excellent yield. Extension of this approach to other 2-fluorobenzonitriles, some of which were elaborated for the first time, showed that this reaction possesses considerable generality. The cyclization was successful even when electron donating groups were present at C(6). Only in 2 cases where a primary or secondary amino group was also present ortho to the cyano group was this transformation unsuccessful.

Journal of Heterocyclic Chemistry published new progress about Cycloaddition reaction. 119584-73-5 belongs to class nitriles-buliding-blocks, name is 2-Ethoxy-6-fluorobenzonitrile, and the molecular formula is C9H8FNO, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 119584-73-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 119584-73-5, name is 2-Ethoxy-6-fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 8: Synthesis of 3-amino-4-ethoxy-7-methanesulfonylamino- benzo [B] THIOPHENE-2-CARBOXYLIC acid amide To a stirred solution of 2-ethoxy-6-fluorobenzonitrile (J. Hynes, J.Heterocycl.Chem. 1988, 25, 1173) (10. 0 G, 60. 54 mmol) in THF (150mL) at-78C was added lithium diisopropylamide (1. 8 M, 44.1 mL, 79. 4MMOL). The mixture was stirred AT-78 C for lh. Then it was poured slowly onto dry ice and stirred until it reached room temperature. The mixture was concentrated to about 10 mL, then diluted with 6N HCI (200mL), and extracted with dichloromethane (3X100 mL). The solvent was washed with brine and dried over NA2S04. The solvent was removed to give product 3-CYANO-4-ETHOXY-2- fluorobenzoic acid (4.2 g, 33.2%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethoxy-6-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/12283; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 119584-73-5, name is 2-Ethoxy-6-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H8FNO

b) 4-Ethoxybenzo[d]isoxazol-3-amine I53 To a solution of acetohydroxamic acid (2.18 g, 29 mmol) in DMF (40 ml.) at 0 C under N2was added t-BuOK (3.26 g, 29 mmol) and the mixture was stirred at RT for 1 h. 2-Ethoxy-6-fluorobenzonitrile I52 (1.6 g, 9.7 mmol) was then added and the mixture was stirred at RT overnight. The mixture was diluted with DCM (80 ml_), washed with water (60 ml. x 4), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Pet.ether/EtOAc = 5/1) to give the title compound (240 mg, 15%) as a white solid. LCMS- E: Rt5.05 min; m/z 179.0 [M+H]+.

According to the analysis of related databases, 119584-73-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CTXT PTY LIMITED; STUPPLE, Paul, Anthony; LAGIAKOS, Helen, Rachel; MORROW, Benjamin, Joseph; FOITZIK, Richard, Charles; HEMLEY, Catherine, Fae; CAMERINO, Michelle, Ang; BOZIKIS, Ylva, Elisabet, Bergman; WALKER, Scott, Raymond; (321 pag.)WO2019/243491; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 119584-73-5, The chemical industry reduces the impact on the environment during synthesis 119584-73-5, name is 2-Ethoxy-6-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

To a solution of 2-ethoxy-6-fluorobenzonitrile (2.00 g, 12.1 mmol, 1 eq) in ethanol (30 mL) was added hydrazine hydrate (0.884 mL, 18.1 mmol, 1.5 eq) at RT. The mixture was heated to 70 C. for 30 h. After cooling to RT, water (20 mL) was added, the mixture was extracted with ethyl acetate (2*50 mL), the combined organic phases were washed with brine (50 mL), dried over MgSO4, filtered and evaporated in vacuo. The residue was triturated with MTBE (10 mL), filtered and the residue was dried for 16 h at 50 C. in vacuo to yield the title compound 4-ethoxy-1H-indazol-3-amine (1.01 g, 47% of theory).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Ethoxy-6-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts