Category: 1194-02-1

Long, Yang; Zheng, Yanling; Xia, Ying; Qu, Lang; Yang, Yuhe; Xiang, Haifeng; Zhou, Xiangge published an article in 2022. The article was titled 《Nickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile》, and you may find the article in ACS Catalysis.Recommanded Product: 1194-02-1 The information in the text is summarized as follows:

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Peng, Yi; Oestreich, Martin published an article in 2022. The article was titled 《B(C6F5)3-Catalyzed Reductive Denitrogenation of Benzonitrile Derivatives》, and you may find the article in Organic Letters.SDS of cas: 1194-02-1 The information in the text is summarized as follows:

A B(C6F5)3-catalyzed reductive denitrogenation of aromatic nitriles ArCN (Ar = 4-fluorophenyl, phenanthren-9-yl, 1-benzothiophen-5-yl, etc.) is reported, achieving the metal-free transformation of a cyano into a Me group in a single synthetic operation. Tris(phenylsilyl)amine is liberated as the nitrogen-containing byproduct. On the basis of control experiments as well as a NMR spectroscopic anal., SN1-type mechanism involving a trisilylammonium ion as a key intermediate is proposed. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1SDS of cas: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.SDS of cas: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Xue, Gaijun; Xie, Fukai; Liang, Hongliang; Chen, Guoliang; Dai, Wen published an article in Organic Letters. The title of the article was 《Copper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles》.Name: 4-Fluorobenzonitrile The author mentioned the following in the article:

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Name: 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Name: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cooperative Molybdenum-Thiolate Reactivity for Transfer Hydrogenation of Nitriles》 was written by Hou, Shu-Fen; Chen, Jia-Yi; Xue, Minghui; Jia, Mengjing; Zhai, Xiaofang; Liao, Rong-Zhen; Tung, Chen-Ho; Wang, Wenguang. Synthetic Route of C7H4FN And the article was included in ACS Catalysis in 2020. The article conveys some information:

A half-sandwich molybdenum(II) thiolate complex with a η2-MeCN ligand, Cp*Mo(1,2-Ph2PC6H4S)(η2-NCMe), was found to catalyze transfer hydrogenation of nitriles efficiently with ammonia borane (H3N•BH3) at room temperature, producing primary amines. Through molybdenum-thiolate cooperation, the B-H bond of BH3 is cleaved, affording a Mo(II)-H hydride (Cp*Mo(1,2-Ph2PC6H4S)H(BH2)) with the BH2 moiety captured at the S-Mo unit. In the presence of NH3, Cp*Mo(1,2-Ph2PC6H4S)H(BH2) smoothly achieves the catalytic transfer hydrogenation of nitriles. The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 4-FluorobenzonitrileIn 2021 ,《4,4′-(Pyridin-4-ylmethylene)dibenzonitrile》 appeared in Molbank. The author of the article were Lancaster, Ben M. J.; Nicholls, Alexander J.; Baxendale, Ian R.. The article conveys some information:

This communication described an unprecedented substitution cascade, in which 4-methylpyridine, following deprotonation with LDA, twice acted as a carbon nucleophile in an unusual SNAr process, to form a novel triarylmethane structure I. A proposed mechanism for this sequence was presented that was supported by single crystal X-ray anal. of the resulting product. This unique transformation was of note as it highlighted a neat and efficient entry as a single step to complex triarylmethane architectures containing both substituted Ph and pyridyl aromatics The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Name: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Name: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Nakamura, Momoko; Yoshida, Kazuhiro; Togo, Hideo published an article in Tetrahedron. The title of the article was 《Novel preparation of 2,5-diarylpyrroles from aromatic nitriles with 3-arylpropylmagnesium bromides, 1,3-diiodo-5,5-dimethylhydantoin, and tBuOK》.Application In Synthesis of 4-Fluorobenzonitrile The author mentioned the following in the article:

Treatment of aromatic nitriles ArCN (Ar = 4-Me, 3-Me, 2-Me, 4-t-Bu, 4-Cl, 3,5-dichloro, 2-naphthyl, etc.) with 3-arylpropylmagnesium bromides (Ar'(CH2)3MgBr = H, Me, Cl) under warming conditions and then with water, followed by the reaction with DIH at room temperature under irradiation with a LED lamp and then with tBuOK gave 2,5-diarylpyrroles in moderate yields. The key step of the present method is the formation of N-iodo-2,5-diaryl-4,5-dihydropyrroles by the reaction of the formed imines with DIH, which proceeds through the 1,5-H shift of iminyl radical, 5-exo-tet cyclization by the imine group, and N-iodination of the formed 2,5-diaryldihydropyrroles.4-Fluorobenzonitrile(cas: 1194-02-1Application In Synthesis of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application In Synthesis of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zhang, Xiuqi; Zhang, Fukuan; Li, Xiaolan; Lu, Ming-Zhu; Meng, Xin; Huang, Lei; Luo, Haiqing published an article in Organic Letters. The title of the article was 《Direct Synthesis of Biphenyl-2-carbonitriles by Rh(III)-Catalyzed C-H Hiyama Cross-Coupling in Water》.COA of Formula: C7H4FN The author mentioned the following in the article:

This method represents an efficient rhodium(III)-catalyzed O-C-H arylation of readily available benzimidate derivatives 2-R-3-R1-4-R2C6H2C(=NH)OR3 (R = H, F, MeO; R1 = H, Me, Br, MeO, F; R2 = H, CF3, I, etc.; R3 = Et, t-Bu, i-Pr, Me) with diverse arylsilanes ArSi(OEt)3 (Ar = 4-methoxyphenyl, 1-naphthyl, thiophen-2-yl, benzodioxol-5-yl, etc.) in water as a sustainable solvent, enabling the straightforward synthesis of potentially useful biphenyl-2-carbonitrile derivatives I. This silicon-based protocol employs benzimidates as both an efficacious directing group and the source of a nitrile group. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1COA of Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.COA of Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cobalt-Catalyzed C(sp2)-CN Bond Activation: Cross-Electrophile Coupling for Biaryl Formation and Mechanistic Insight》 was published in ACS Catalysis in 2020. These research results belong to Dorval, Celine; Tricoire, Maxime; Begouin, Jeanne-Marie; Gandon, Vincent; Gosmini, Corinne. Safety of 4-Fluorobenzonitrile The article mentions the following:

Herein, we report a cross-electrophile coupling of benzonitrile derivatives and aryl halides with a simple cobalt-based catalytic system under mild conditions to form biaryl compounds Even though the cobalt catalyst is able to activate the C(sp2)-CN bond alone, the use of the AlMe3 Lewis acid enhances the reactivity of benzonitriles and improves the cross-selectivity with barely any influence on the functional group compatibility. X-ray structure determination of an original low-valent cobalt species combined with catalytic and stoichiometric reactions reveals a catalytically active cobalt(I) species toward the aryl halide partner. On the other hand, exptl. insights, including cyclic voltammetry experiments, suggest the involvement of a cobalt complex of a lower oxidation state to activate the benzonitrile derivative Finally, d. functional theory calculations support the proposed mechanistic cycle involving two low-valent cobalt species of different oxidation states to perform the reaction. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Organic aluminum hydrides catalyze nitrile hydroboration》 were Liu, Wenqing; Ding, Yi; Jin, Da; Shen, Qiumiao; Yan, Ben; Ma, Xiaoli; Yang, Zhi. And the article was published in Green Chemistry in 2019. Product Details of 1194-02-1 The author mentioned the following in the article:

Economical and eco-friendly aluminum hydrides were shown to be highly efficient catalysts for the solvent-free hydroboration of various nitriles using pinacolborane. The catalytic activities of three organic aluminum hydrides were compared. Mechanism investigation experiments revealed that nitrile was reduced to an imine intermediate by aluminum hydrides. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chemical Science included an article by Ueda, Yohei; Tsujimoto, Nagataka; Yurino, Taiga; Tsurugi, Hayato; Mashima, Kazushi. Synthetic Route of C7H4FN. The article was titled 《Nickel-catalyzed cyanation of aryl halides and triflates using acetonitrile via C-CN bond cleavage assisted by 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine》. The information in the text is summarized as follows:

A non-toxic cyanation reaction of various aryl halides and triflates in acetonitrile using a catalyst system of [Ni(MeCN)6](BF4)2, 1,10-phenanthroline, and 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine (Si-Me4-DHP) is developed. Si-Me4-DHP was found to function as a reductant for generating nickel(0) species and a silylation reagent to achieve the catalytic cyanation via C-CN bond cleavage. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts