Category: 1194-02-1

The author of 《SO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles》 were Zhao, Yiyong; Mei, Guangyao; Wang, Haibo; Zhang, Guofu; Ding, Chengrong. And the article was published in Synlett in 2019. Related Products of 1194-02-1 The author mentioned the following in the article:

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Surpassing Robeson Upper Limit for CO2/N2 Separation with Fluorinated Carbon Molecular Sieve Membranes》 was written by Yang, Zhenzhen; Guo, Wei; Mahurin, Shannon Mark; Wang, Song; Chen, Hao; Cheng, Long; Jie, Kecheng; Meyer, Harry M. III; Jiang, De-en; Liu, Gongping; Jin, Wanqin; Popovs, Ilja; Dai, Sheng. Application of 1194-02-1 And the article was included in Chem in 2020. The article conveys some information:

The CO2-philic properties of powd. fluorinated triazine frameworks make them promising candidates for fabrication of porous CO2 separation membranes. This is rarely reported because of lack of suitable synthetic approaches. Here, fluorinated membranes based on covalent triazine frameworks are prepared through a rational design of aromatic nitrile monomers containing fluorine and ether groups via a sol-gel polymerization process. The CO2 separation performance rises significantly with the fluorine content in the membrane. With functionalized triazine units, fluorine, and ether groups, these carbon mol. sieve membranes obtained after pyrolysis exhibit intrinsic ultra-micropores, high surface areas and excellent thermal stability under air. Excellent CO2 permeability and CO2 to N2 selectivity surpassing the Robeson upper bound are achieved. Our general design and synthesis protocol allow an easy access to fluorinated porous membranes, thus significantly expanding the currently limited library of CO2-philic and chem. stable membranes for highly efficient CO2 separation The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Chem included an article by Zhao, Da; Xu, Peng; Ritter, Tobias. Category: nitriles-buliding-blocks. The article was titled 《Palladium-Catalyzed Late-Stage Direct Arene Cyanation》. The information in the text is summarized as follows:

The first general late-stage aryl C-H cyanation with broad substrate scope and functional-group tolerance was reported. The reaction was enabled by a dual-ligand combination of quinoxaline and an amino acid-derived ligand. The method was applicable to direct cyanation of several marketed small-mol. drugs, common pharmacophores and organic dyes.4-Fluorobenzonitrile(cas: 1194-02-1Category: nitriles-buliding-blocks) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Organometallics included an article by Ding, Yi; Ma, Xiaoli; Liu, Yashuai; Liu, Wenqing; Yang, Zhi; Roesky, Herbert W.. Synthetic Route of C7H4FN. The article was titled 《Alkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides》. The information in the text is summarized as follows:

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《A Convenient Synthesis of 1,5-Fused 1,2,4-Triazoles from N -Arylamidines via Chloramine-T Mediated Intramolecular Oxidative N-N Bond Formation》 were Bhatt, Ashish; Singh, Rajesh K.; Kant, Ravi; Sarma, Bhupendra K.. And the article was published in Synthesis in 2019. Formula: C7H4FN The author mentioned the following in the article:

A convenient synthesis of 1,5-fused 1,2,4-triazoles from readily available N-arylamidines was reported. The reaction was efficiently promoted by chloramine-T to afford the desired products mostly in high yields and in relatively short time, through direct metal-free oxidative N-N bond formation. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. This protocol was effective toward various substrates having different functionalities. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,ACS Catalysis included an article by Chen, Hao; Mondal, Arup; Wedi, Philipp; van Gemmeren, Manuel. Related Products of 1194-02-1. The article was titled 《Dual Ligand-Enabled Nondirected C-H Cyanation of Arenes》. The information in the text is summarized as follows:

Aromatic nitriles are key structural units in organic chem. and, therefore, highly attractive targets for C-H activation. Herein, the development of an arene-limited, nondirected C-H cyanation based on the use of two cooperatively acting com. available ligands is reported. The reaction enables the cyanation of arenes by C-H activation in the absence of directing groups and is therefore complementary to established approaches. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Nickel-Catalyzed Hydrophosphonylation and Hydrogenation of Aromatic Nitriles Assisted by Lewis Acid》 were Islas, Rosa E.; Garcia, Juventino J.. And the article was published in ChemCatChem in 2019. Reference of 4-Fluorobenzonitrile The author mentioned the following in the article:

In this paper, we describe the catalytic hydrophosphonylation of several aromatic nitriles used to synthesize α-aminophosphonates (α-APs) using com. available trialkyl phosphites (P(OR)3, R=Et, iPr, Bu,) and simple and inexpensive nickel chloride (NiCl2.6H2O) as the catalytic precursor. The use of triethylborane (Et3B) as a Lewis acid (LA) was mandatory in order to successfully perform H-phosphite moiety incorporation at the CN bond of non-activated benzonitriles (BN) derivatives Interestingly, when a highly activated BN such as 2,3,4,5,6-pentafluorobenzonitrile (BN-g) was employed, it was possible to perform the reaction in the absence of an LA using milder reaction conditions. Also, we found that using HP(O)(OiPr)2 as a starting material afforded the aminobisphosphonate derivative with better selectivity than using the method involving P(OiPr)3 as the initial reagent. Remarkably, when using HP(O)(OiPr)2 with an excess of Et3B, the reaction’s selectivity completely changed to yield N-benzyl- benzylimine (BBI) and 2,4,5-triphenylimidazole. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Reference of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Yi; Liu, Wenbo; Ren, Yun-Lai; Guo, Yinggang; Tian, Xinzhe published their research in ChemistrySelect in 2021. The article was titled 《Copper-Catalyzed Cleavage of Aryl C(OH)-C Bonds to Access Aryl Nitriles》.Product Details of 1194-02-1 The article contains the following contents:

It was found that aryl nitriles could be synthesized by cleavage of aryl C(OH)-C bonds in the presence of oxygen gas, (NH4)2CO3 and Cu(OAc)2. The present protocol allowed various secondary aryl alcs. to underwent the present transformation to give aryl nitriles in low to high yields. Lignin-related β-O-4 and β-1 linkages could be converted to benzonitriles under the present conditions, which provides an avenue to obtain value nitrile products via fragmentation of lignin. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Sequential C-H and C-C Bond Cleavage: Divergent Constructions of Fused N-Heterocycles via Tunable Cascade》 were Li, Xianwei; Rao, Jianhang; Ouyang, Wensen; Chen, Qian; Cai, Ning; Lu, Yu-Jing; Huo, Yanping. And the article was published in ACS Catalysis in 2019. Quality Control of 4-Fluorobenzonitrile The author mentioned the following in the article:

Streamlining the generation of diverse highly functionalized mols. from abundant feedstocks holds great synthetic promises and challenges in pharmaceutical and material discovery. Herein, we report a tunable selectivity in multiple cascade reactions for the divergent assembly of fused N-heterocycles, comprising sequential activation of C-H and C-C bonds. Isolatable indene-type intermediates might be responsible for the generation of densely substituted fused pyridines, azepines, and azafluorenones products. The tolerance of strongly coordinating N-heterocycles, and those readily applicable for the late-stage modifications of pharmaceuticals and material mols. precursors, further demonstrated the synthetic robustness of this transformation. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Quality Control of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Green Chemistry included an article by Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; Wang, Bo. Application of 1194-02-1. The article was titled 《Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O》. The information in the text is summarized as follows:

The first example of a mild and high-efficiency protocol enabling a process in water using 1 atm of H2 for the efficient and selective hydrogenation of nitriles RCN [R = CH3(CH2)2, 4-FC6H4, naphthalen-1-yl, etc.], nitro compounds 4-R1C6H4NO2 (R1 = H, F, Cl, Br, OH, Me, MeO, NH2), ketones R2C(O)R3 [R2 = CH3(CH2)2, 3-FC6H4, 2-H3CC6H4, etc.; R3 = Me, CF3] and aldehydes R4CHO [R4 = 4-(H3C)2CHC6H4, 3,4,5-(H3CO)3C6H2, naphthalen-1-yl, etc.], to yield primary amines RCH2NH2, 4-R1C6H4NH2 and alcs. R2CH(OH)CH3, R4CH2OH with satisfactory yields of up to >99% has been presented. Several palladium-based nanoparticle catalysts were prepared from K2PdCl4 and ligands, and one of them was found to be the best and most suitable for the hydrogenation of CN, C-NO2 and C=O bonds. In addition, the catalyst Pd-NPs can be easily recycled and reused without losing their activity and selectivity. A plausible mechanism for the hydrogenation of a CN bond was also proposed, representing the first example that possesses great potential for sustainable industrial purposes. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts