Category: 1187-42-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1187-42-4 as follows. HPLC of Formula: C4H4N4

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

According to the analysis of related databases, 1187-42-4, the application of this compound in the production field has become more and more popular.

Related Products of 1187-42-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187-42-4 name is Diaminomaleonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: AlCl3 (15 molpercent) was added to a solution of DAMN (1 mmol), ketone (1 mmol) and isocyanide (1 mmol), in 5 ml of CH3CN. The resulting mixture was stirred for an appropriate time at room temperature. After completion of the reaction, as indicated by thin-layer chromatography (TLC; ethyl acetate=n-hexane 3=1), the product was precipitated by addition of 10 ml of water. The precipitate was filtered off, washed with water, and then recrystallized from acetone. In the case of aromatic aldehyde, precipitate after filtration was loaded on column chromatography with 20percent ethyl acetate?hexane as an eluent system to furnish the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diaminomaleonitrile, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1187-42-4, name is Diaminomaleonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H4N4

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.

Application of 1187-42-4, These common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound D (0.70 g, 1.50 mmol), diaminomaleonitrile (0.19 g, 1.80 mmol), 40 mL of ethanol, 40 mL of THF (tetrahydrofuran), and 0.23 mL of 12M hydrochloric acid were charged in a three-necked flask having a capacity of 300 mL, and then the resultant mixture was stirred while conducting heating at 40 C. for 24 hours. Water was added to the resultant solution, the resultant mixture was subjected to extraction with chloroform, and then the resultant extract was dried by adding sodium sulfate thereto. Sodium sulfate hydrate was removed by filtration, and the solvent was distilled off from the filtrate using an evaporator. The resulting solid was purified by silica gel column chromatography (developing solvent: toluene) to obtain a red solid (yield amount: 0.40 g, yield: 49%). Chemical shift values (delta) of the compound measured by 1H NMR (400 MHz, CDCl3) were as follows: delta 9.31 (d, J=8.8 Hz, 1H), 9.24 (dd, J=8.0 Hz, 1.2 Hz, 1H), 8.90 (d, 1.6 Hz, 1H), 8.78 (d, J=8.4 Hz, 1H), 8.13 (dd, J=8.4 Hz, 1.6 Hz, 1H), 8.05 (d, J=8.4 Hz, 2H), 8.00 (td, J=7.2 Hz, 1.6 Hz, 1H), 7.89 (td, J=7.2 Hz, 1.2 Hz 1H), 7.57 (d, J=8.4 Hz, 2H), 6.69 (m, 6H), 6.06 (dd, J=8.0 Hz 2.0 Hz, 2H). It was confirmed by 1H NMR measurement that the obtained compound was a compound 1 (Px-CNBQx).

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION; Nippon Soda Co., Ltd.; YASUDA, Takuma; FURUE, Ryuhei; ISHIHARA, Hiroyuki; FUKUSHIMA, Yukio; (61 pag.)US2019/330162; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1187-42-4,Some common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: AlCl3 (15 molpercent) was added to a solution of DAMN (1 mmol), ketone (1 mmol) and isocyanide (1 mmol), in 5 ml of CH3CN. The resulting mixture was stirred for an appropriate time at room temperature. After completion of the reaction, as indicated by thin-layer chromatography (TLC; ethyl acetate=n-hexane 3=1), the product was precipitated by addition of 10 ml of water. The precipitate was filtered off, washed with water, and then recrystallized from acetone. In the case of aromatic aldehyde, precipitate after filtration was loaded on column chromatography with 20percent ethyl acetate?hexane as an eluent system to furnish the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diaminomaleonitrile, its application will become more common.

Reference:
Article; Bhosale, Shrikar M.; Naik, Nilesh H.; Kusurkar, Radhika S.; Synthetic Communications; vol. 43; 23; (2013); p. 3163 – 3169;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 1187-42-4,Some common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-[(Benzen-1-yl)methyleneamino]-3-aminomaleonitrile(L) was prepared by a modification of the method described in the literature [18]. To a solution of benzaldehyde (0.500 g,4.71 mmol) in methanol (10 ml), a solution of 2,3-diaminomaleonitrile(0.509 g, 4.71 mmol) in methanol(10 ml) was added dropwise with constant stirring. Theresulting mixture was refluxed at about 80 C for 5 h until completion of the reaction (checked by TLC). The product2-[(benzen-1-yl)methyleneamino]-3-aminomaleonitrile obtained was filtered off and purified by column chromatography(ether:dichloromethane) to afford a yellowish-brown solid.Yield: 0.847 g (84percent); Elemental analyses (C, H and N,wtpercent) Anal. Calc. for C11H8N4: C, 67.3; H, 4.1, N, 28.5;found: C, 67.3; H, 4.09; N, 28.5percent; IR (KBr, m/cm-1): 3404 s,3298w, 2237w, 2204 s, 1605 s; 1HNMR(CDCl3; 300 MHz):d 8.46 (s, 1H, HC=N), d 7.46?7.96 (m, 5H, phenyl), d 7.45 (s,2H,NH2); 13CNMR(CDCl3; 300 MHz): d 156.61(HC=N), d128.99?128.88 (phenyl-C), d 115.84 (CN), d 114.85 (CN), d113.61 (HCNC=C), d 104.65 (CNC=C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diaminomaleonitrile, its application will become more common.

Reference:
Article; Devkule; Chavan; Transition Metal Chemistry; vol. 42; 4; (2017); p. 347 – 356;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 1187-42-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1187-42-4, name is Diaminomaleonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

The chemical industry reduces the impact on the environment during synthesis Diaminomaleonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Kalhor, Mehdi; Seyedzade, Zahra; Research on Chemical Intermediates; vol. 43; 5; (2017); p. 3349 – 3360;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1187-42-4,Some common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, molecular formula is C4H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under N2 atmosphere, bi-indole (420 mg, 1.4 mmol), diaminomaleonitrile (240 mg, 2.2 mmol) and sulfamic acid (1200 mg, 12.0 mmol) were refluxed in 30 mL of methanol for 3 h. The residual methanol was removed by vacuum distillation, then the resulting precipitate was washed by saturated aq. NaHCO3 and dried in vacuo to afford a yellow solid. The solid was subjected to chromatography over silica gel (ethyl acetate:petroleum ether, 1:1) to give 1 as yellow powder in about 80percent yield. 1H NMR (400 MHz, DMSO-d6, TMS): delta 7.10 (t, 2H, J = 7.3 Hz), 7.20 (t, 2H, J = 7.5 Hz), 7.48 (d, 2H, J = 8.0 Hz), 7.75 (d, 2H, J = 8.2 Hz), 7.81 (d, 2H, J = 2.4 Hz), 11.85 (s, 2H); ESI-MS (m/z): 359.2 [M?H]?, 394.6 [M+Cl]?, 754.5 [2M+Cl]?; HRMS (ESI) (m/z): 359.1047 [M?H]?, calcd. for C22H12N6 360.3709.

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Xiu-Ming; Zhao, Qiang; Li, Yue; Song, Wei-Chao; Li, Ya-Ping; Chang, Ze; Bu, Xian-He; Chinese Chemical Letters; vol. 24; 11; (2013); p. 962 – 966;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 1187-42-4, These common heterocyclic compound, 1187-42-4, name is Diaminomaleonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 mL two-necked flask, 2.6 lg (10 mmol) of 5-bromoacenaphthenequinone, 1.08 g (10 mmol) of diaminomaleonitrile, and 60 mL of acetic acid were sequentially added thereto, and the temperature was raised to 120 ¡ã C, and the mixture was stirred under reflux for 24 hours. The mixture was cooled to room temperature, poured into water, filtered under reduced pressure and washed with a large amount of water. The residue was dried and separated and purified on a silica gel column using dichloromethane: petroleum ether = 3:1 (volume ratio) eluent to obtain yellow. 3-bromoacenaphthenequinoneopyrazine-8,9-dicarbonitrile 2.44g, yield 77¡¤27percent

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Soochow University (Suzhou); Liao Liangsheng; Yuan Yi; Jiang Zuoquan; Hu Yun; (37 pag.)CN108440424; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1187-42-4, name is Diaminomaleonitrile, A new synthetic method of this compound is introduced below., Quality Control of Diaminomaleonitrile

Example 1-1; Methanol, in an amount of 216 mL, was placed in a four-necked flask with a volume of 500 mL, and 108.1 g (purity: 98.7percent, 0.987 mol) of DAMN and 116.73 g (1.100 mol) of trimethyl orthoformate were added thereto. p-Toluenesulfonic acid, monohydrate, in an amount of 190 mg, was added to the aforementioned mixture, and the reaction mixture was stirred while maintaining the temperature at 65¡ãC. 45 minutes after stirring was started, crystals of MMD were precipitated, and completion of the reaction was suggested. After the reaction mixture was stirred for 1.5 hours, the reaction mixture was cooled to 5¡ãC. The crystals were filtered and washed with 100 mL of cooled methanol, followed by drying. Thereby, 118.56 g (0.852 mol, yield = 80percent) of methyl N-(2-amino-1,2-dicyanovinyl)formimidate (MMD) was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nippon Soda Co., Ltd.; EP2138480; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts