Category: 118431-88-2

Synthetic Route of 118431-88-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a cooled solution of potassium ieri-butylate (91.6mmol, 1.1 equiv.) in THF (260ml) was added a solution of 3-cyclopropyl-3-oxo-propionitrile (83.2mmol, 1.0 equiv.) in THF (130ml) over 30 minutes, while maintaining the temperature at 0C. After stirring for an additional hour at 0C, the solution was cooled to -20C. The respective isothiocyanate (83.2mmol, 1.0 equiv.) was dissolved in THF (130ml) and added to the orange solution over 25 minutes. The reaction mixture was allowed to warm to room temperature. TLC indicated complete conversion of starting material. The clear solution was poured onto ice-cold IN HCl (1L), extracted with dichloromethane (1L), dried over Na2SO4 and evaporated to dryness. The resulting raw-solid was recrystallized from MTBE.

The chemical industry reduces the impact on the environment during synthesis 3-Cyclopropyl-3-oxopropanenitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ALGIAX PHARMACEUTICALS GMBH; HASSE, Birgit; KOOPMANS, Guido; (41 pag.)WO2015/140081; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 118431-88-2, A common heterocyclic compound, 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl hydrazine (lmL) was added to a solution of 3-cyclopropyl-3-oxopropanenitrile (lg, 9.l7mmol) in ethanol (l5mL). The resulting reaction mass was heated to reflux for 12h. The reaction mass was quenched with ice cold water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the title compound (1.lg, 97%) LCMS: mlz = 138 (M+H)t

The synthetic route of 118431-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SAMAJDAR, Susanta; PODDUTOORI, Ramulu; PANDIT, Chetan; MUKHERJEE, Subhendu; GOSWAMI, Rajeev; (126 pag.)WO2016/193939; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 118431-88-2, A common heterocyclic compound, 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compounds listed below may be prepared in manner similar to the method described above. COMPOUND 638: 1-[2-chloro-4-(methylsulphonyl)phenyl]-2-cyano-3-cyclopropylpropan-1,3-dione, m.p. 145 C., starting from 3-cyclopropyl-3-oxopropanonitrile and 2-chloro-4-(methylsulphonyl)benzoyl chloride.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Rhone-Poulenc Agriculture Limited; US5804532; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, molecular formula is C6H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

To a 50 mL round-bottom flask containing 3-cyclopropyl-3-oxopropanenitrile 201 (1.63 g, 14.94 mmol, 1.0 equiv.), ethanol (20 mL), and TEA ( 1.51 g, 14.92 mmol, 1 .0 equiv.), N- hydroxybicyclo[2.2.2]oct-l-carbonimidoyl chloride 20h (2.8 g, 14.92 mmol, 1.0 equiv.) was added. The reaction mixture was stirred for 5 rain at 0 C and then for 2 h at RT. The resulting mixture was diluted with EtOAc (300 mL), washed with brine ( 100 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product was purified by Flash-Prep-HPLC using the following conditions: Column, silica gel; mobile phase, PE:EtOAc = 100:0 increasing to PE_EtOAc=80:20 within 30 min; Detector, UV 254 ran. Removal of solvents provided 3-[bicyclo[2.2.2]octan-l -yl]-5-cyclopropyl-l,2-oxazole-4-carbonitrile 20j (1.7 g, 47%) as a light yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 118431-88-2, its application will become more common.

Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (249 pag.)WO2018/39384; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118431-88-2, Recommanded Product: 3-Cyclopropyl-3-oxopropanenitrile

3-Cyclopropyl-3-oxopropanenitrile (3.30 g, 30 mmol) and4-hydrazinylpyridine-HC1 (3g, 20 mmol) were dissolved in ethanol and the solution was heated at reflux for 12 h. The reaction mixture was concentrated and re-dissolvedethyl acetate. The solution was neutralized with NaOH solution and the aqueous layer was extracted with ethyl acetate, the combined organic layers were washed with brine, then dried over anhydrous Na2SO4. The volatile components were removed on a rotary evaporator and the residues were dissolved in methanol (10 mL) followed by addition of CF3CO2H (10 mL). The reaction mixture was stirred at room temperature for 12 h and the volatile components were removed on a rotary evaporator. The remaining residues were purified by flash column chromatography affording 3-cyclopropyl-1-(pyridin-4-yl)-1H-pyrazol-5-amine in 3.52 g. ?H NMR (300 MHz, MeOD-d4): 8.56 (dd, I = 4.75, 1.58 Hz, 2H), 7.68 (dd, I = 4.74, 1.59 Hz, 2H), 5.58 (s, 1H), 1.84-1.74 (m, 1H), 0.90-0.82 (m, 2H), 0.66-0.60 (m, 2H). ESI-MS calculated for C11H13N4 [M+H]= 201.11; Observed: 201.58.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Cyclopropyl-3-oxopropanenitrile, and friends who are interested can also refer to it.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHAO, Yujun; ZHOU, Bing; AGUILAR, Angelo; (114 pag.)WO2016/138332; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 136a (477 mg, 4.38 mmol) in MeOH (5 mL) was added N2H4.H20 (80%) (5 mL). The reaction mixture was heated at 75C for 15 h. MeOH was removed under reduced pressure. The residue was extracted with CH2CI2 (2 X 8 mL ), dried over Na2S04, and concentrated. The residue was purified by flash column eluting with 100: 1 CH2CI2/ MeOH to afford 136b as a yellow oil (37%, for two steps). LCMS: (M+H)+ 124.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GILEAD CONNECTICUT, INC.; GENENTECH, INC.; BARBOSA, Antonio, J., M.; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KRISHNAMOORTHY, Ravi; KROPF, Jeffrey, E.; LEE, Seung H.; MITCHELL, Scott A.; ORTWINE, Daniel; SCHMITT, Aaron, C.; WANG, Xiaojing; XU, Jianjun; YOUNG, Wendy; ZHANG, Honglu; ZHAO, Zhongdong; ZHICHKIN, Pavel E.; WO2011/140488; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 118431-88-2, The chemical industry reduces the impact on the environment during synthesis 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, I believe this compound will play a more active role in future production and life.

3-Cyclopropyl-3-oxopropanenitrile (2.61 g, 24 mmol) and 4-hydrazinylbenzoic acid (3.0 g, 20 mmol) were dissolved in ethanol and the solution was heated at reflux for 12 h. The reaction mixture was concentrated and re-dissolved in methanol (30 mL) followed by addition of CF3CO2H (15 mL). The reaction mixture was stirred at room temperature for 12 h and the volatile components were removed on a rotary evaporator. The remaining residues were washed with ethyl acetate and 4-(5-amino-3-cyclopropyl- 1H-pyrazol-1-yl)benzoic acid was collected by filtration as a solid (6.44 g). ?H NMR (400 MHz, DMSO-d6): 8.02 (d, I = 8.70 Hz, 2H), 7.74 (d, I = 8.70 Hz, 2H), 5.30 (s, 1H), 1.85-1.75 (m, 1H), 0.95-0.85 (m, 2H), 0.73-0.65 (m, 2H). ESI-MS calculated for C,3H,4N302[M+Hj+ = 244.11; Observed: 244.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHAO, Yujun; ZHOU, Bing; AGUILAR, Angelo; (114 pag.)WO2016/138332; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118431-88-2, Application In Synthesis of 3-Cyclopropyl-3-oxopropanenitrile

COMPOUND 613: 2-cyano-1-cyclopropyl-3-[2-(ethylsulphonyl)phenyl]propan-1,3-dione, m.p. 169 C., starting from 3-cyclopropyl-3-oxopropanonitrile and 2-(ethylsulphonyl)benzoyl chloride.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Rhone-Poulenc Agriculture Limited; US5804532; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Hydrazine hydrochloride 14a or b was refluxed with nitrile 12a,b or c in EtOH overnight. The reaction solution was evaporated in vacuo to furnish the corresponding pyrazolo amine, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

N-(3-Cyclopropyl-1-(2-methoxyethyl)-1H-pyrazol-5-yl)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine (Cpd No. 266) Step 1: 3-Cyclopropyl-3-oxopropanenitrile (1.4 g, 8 mmol) and 2-methoxyethyl hydrazine-HCl (1.0 g, 8.0 mmol) were mixed in ethanol (20 mL) and heated at reflux for overnight. The reaction mixture was cooled to room temperature and ethanol was removed on a rotary evaporator. Water was added and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated on a rotary evaporator. The remaining residue was purified by flash column chromatography to yield 3-cyclopropyl-1-(2-methoxyethyl)-1H-pyrazol-5-amine in 0.89 g (4.92 mmol, 62% yield). 1H NMR (CDCl3, 300 MHz): 5.12 (s, 1H), 4.12-4.06 (m, 2H), 3.95 (s, 2H), 3.70-3.64 (m, 2H), 3.32 (s, 3H), 1.95-1.70 (m, 1H), 0.90-0.80 (m, 2H), 0.70-0.60 (m, 2H). ESI-MS calculated for C9H16N3O [M+H]+=182.13, Observed: 182.50.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; Wang, Shaomeng; Zhao, Yujun; Zhou, Bing; Aguilar, Angelo; Liu, Liu; Bai, Longchuan; McEachern, Donna; Sun, Duxin; Wen, Bo; Luo, Ruijuan; Zhao, Ting; Chinnaiyan, Arul; Asangani, Irfan A.; Stuckey, Jeanne; Meagher, Jennifer Lynn; Ran, Xu; US2015/246923; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts