Category: 115279-57-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H12N2

A mixture of compound 3 (6.75g, 0.0215mol) and 2-(4-aminophenyl)-2-methylpropanenitrile (compound 4, 3.72g, 0.0233mol) in 2-propanol (25ml) was heated at reflux for 30min. The precipitated solid was collected and dried to give ethyl 6-bromo-4-(4-(2-cyanopropan-2-yl)phenylamino)quinoline-3-carboxylate (compound 5, 8.35g, 88.9%) as a bright yellow solid.

According to the analysis of related databases, 115279-57-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ADVENCHEN PHARMACEUTICALS, LLC; GUOQING, Paul, Chen; CHANGREN, Yan; MONICA, Chen; (33 pag.)WO2017/11363; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 115279-57-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate (6.4 g, 23.6 mmol) and 2-(4-aminophenyl)-2-methylpropionitrile (5.6 g, 35 mmol) were dissolved in tert-butanol (200 mL), to the system added potassium carbonate (16.4 g, 119 mmol), and the reaction mixture was stirred under reflux for 2 h. After confirming a disappearance of the raw materials by a thin layer chromatography plate (ethyl acetate:petroleum ether=1:3), the reaction mixture was suction filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was washed with diethyl ether to give 8.1 g of a pale yellow solid.

The synthetic route of 2-(4-Aminophenyl)-2-methylpropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Wu, Frank; Zhang, Yan; US2015/166539; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., Product Details of 115279-57-7

N-Chloro-succinimide (91.0 mg; 0.68 mmol) was added to a solution of 2-(4-amino- phenyl)-2-methyl-propionitrile (100 mg; 0.62 mmol), prepared as described in 1(B), in isopropanol (3 mL). The resulting solution was stirred at reflux for Ih. Then the solvent was evaporated under vacuum and the crude was portioned between EtOAc and H2O. The layers were separated and the organic phase was washed with brine, dried over Na2SO4, filtrated and concentrated under reduced pressure. The crude was purified by chromatography [SiO2, DCM] to afford the title compound as an orange oil (58.0 mg; 48% yield).1H NMR (300 MHz, CDC13) delta(ppm): 7.34 (d, 1 H), 7.18 (dd, 1 H), 6.78 (d, 1 H), 3.73(br. s., 2 H), 1.68 (s, 6 H).LCMS (RT): 4.63 min (Method B); MS (ES+) gave m/z: 195.05 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ADDEX PHARMA SA; WO2008/117175; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., Product Details of 115279-57-7

10556] The above reaction scheme illustrates the synthesis of a compound of the invention 2-13. Methylation of starting material 2-1 yields compound 2-2, which is subsequently reduced to the amine 2-3. In a separate reaction, compound 2-4 is converted to a salt, such as an HC1 salt, which is then reacted, for example, with 2-nitrovinyl-hydroxylamine to yield compound 2-6. Further cyclization yields compound 2-7. Halogenation with a reagent such as POd3 results in compound 2-8, which can be coupled with intermediate 2-3 to yield 2-9. The nitro moiety of 2-9 is subsequently reduced to an amine, and a further reaction with 4-nitrophenyl carbonochloridate results in the heterocycle 2-11. The desired compound 2-13 is then prepared by coupling to the benzoxazolyl boronate 2-12, for example in a Suzuki coupling.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Intellikine LLC; Ren, Pingda; Liu, Yi; Li, Liansheng; Chan, Katrina; Wilson, Troy Edward; Campbell, Simon Fraser; US2015/320727; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 115279-57-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

10210] 4,6-dichloro- 1 ,5-naphthyridine-3-carboxylate ethyl (5.9 g, 21.9 mmol) and 2-(4-aminophenyl)-2-methyl propanenitrile (3.5 g, 21.9 mmol) were dissolved in 100 mE tert-butanol. To the resulting mixture was added potassium carbonate (6.0 g, 43.8 mmol). The reaction mixture was heated to reflux and reacted for 15 hrs. The reaction was cooled to room temperature, and then concentrated in a reduced pressure. To the residue was added 100 mE water and 100 mE DCM. The phases were separated. The aqueous phase was extracted with 100 mE DCM. The organic phases were combined, dried over anhydrous sodium sulfate, and concentrated. The resulting crude product is separated by silicagel column chromatography (EtOAc/PE=0-1/2) to obtain a pale yellow solid of 6-chloro-4-((4-(2-cyanopropan- 2-yl)phenyl)amino)-1 ,5-naphthyridine-3-carboxylate ethyl(6.9g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Aminophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Wu, Frank; Shu, Chutian; US2015/239885; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 115279-57-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate (6.4 g, 23.6 mmol) and 2-(4-aminophenyl)-2-methylpropionitrile (5.6 g, 35 mmol) were dissolved in tert-butanol (200 mL), to the system added potassium carbonate (16.4 g, 119 mmol), and the reaction mixture was stirred under reflux for 2 h. After confirming a disappearance of the raw materials by a thin layer chromatography plate (ethyl acetate:petroleum ether=1:3), the reaction mixture was suction filtered, the filtrate was concentrated under reduced pressure, and the resulting residue was washed with diethyl ether to give 8.1 g of a pale yellow solid.

The synthetic route of 2-(4-Aminophenyl)-2-methylpropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; XUANZHU PHARMA CO., LTD.; Wu, Frank; Zhang, Yan; US2015/166539; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115279-57-7, Safety of 2-(4-Aminophenyl)-2-methylpropanenitrile

Step 1. 2-[4-(4,5-dichloro-2-nitroanilino)phenyl]-2-methylpropanenitrile The title compound was prepared according to the procedure described in step 3 of Example 1 from 2,4,5-trichloronitroaniline and 2-(4-aminophenyl)-2-methylpropanenitrile (Axton, C. A.; et al. J.Chem.Soc.Perkin Trans.], 1992, 17, 2203). 1H-NMR (CDCl3) delta9.38 (1H, br), 8.31 (1H, s), 7.54 (2H, d, J=8.58 Hz), 7.30-7.22 (3H, m), 1.75 (6H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Audoly, Laurent; Okumura, Takako; Shimojo, Masato; US2002/77329; (2002); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H12N2

A mixture of compound 3 (6.75g, 0.0215mol) and 2-(4-aminophenyl)-2-methylpropanenitrile (compound 4, 3.72g, 0.0233mol) in 2-propanol (25ml) was heated at reflux for 30min. The precipitated solid was collected and dried to give ethyl 6-bromo-4-(4-(2-cyanopropan-2-yl)phenylamino)quinoline-3-carboxylate (compound 5, 8.35g, 88.9%) as a bright yellow solid.

According to the analysis of related databases, 115279-57-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ADVENCHEN PHARMACEUTICALS, LLC; GUOQING, Paul, Chen; CHANGREN, Yan; MONICA, Chen; (33 pag.)WO2017/11363; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 115279-57-7

N-Chloro-succinimide (91.0 mg; 0.68 mmol) was added to a solution of 2-(4-amino- phenyl)-2-methyl-propionitrile (100 mg; 0.62 mmol), prepared as described in 1(B), in isopropanol (3 mL). The resulting solution was stirred at reflux for Ih. Then the solvent was evaporated under vacuum and the crude was portioned between EtOAc and H2O. The layers were separated and the organic phase was washed with brine, dried over Na2SO4, filtrated and concentrated under reduced pressure. The crude was purified by chromatography [SiO2, DCM] to afford the title compound as an orange oil (58.0 mg; 48% yield).1H NMR (300 MHz, CDC13) delta(ppm): 7.34 (d, 1 H), 7.18 (dd, 1 H), 6.78 (d, 1 H), 3.73(br. s., 2 H), 1.68 (s, 6 H).LCMS (RT): 4.63 min (Method B); MS (ES+) gave m/z: 195.05 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ADDEX PHARMA SA; WO2008/117175; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 115279-57-7, The chemical industry reduces the impact on the environment during synthesis 115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, I believe this compound will play a more active role in future production and life.

18 g (62.6 mmol) of 6-bromo-4-chloro-3-nitro-quinoline (Example lc) and 11 g(68.9 mmol) of (2-(4-amino-phenyl)-2-methyl-propionitrile (Example le) are dissolved in 350 ml of acetic acid and stirred for 2 h. After this time, water is added and the yellow precipitate is filtered off and washed with H2O. The solid is dissolved in EtOAc-THF (1 : 1), washed with sat. aqueous NaHC03and dried over MgS04. The organic phase is evaporated to dryness to give the title compound as a yellow solid. ES-MS: 411, 413 (M + H)+, Br pattern; analytical HPLC: tret= 3.69 min (Grad 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Aminophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo; WO2013/23119; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts