Category: 114772-53-1

Application of 114772-53-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A jacketed 1,000 mL 3-neck flask was charged with 4′-methylbiphenyl-2-carbonitrile (Compound 1, 100.0 g) and CH2Cl2 (500 mL) under nitrogen. To a 500 mL Erlenmeyer flask with magnetic stirrer, sodium bromate (NaBrO3; 31.2 g) was dissolved in water (170 mL). The NaBrO3 solution was transferred to the 1,000 mL flask and the reaction mixture was cooled to about 5 C. or less. Aqueous HBr solution (48%, 105.0 g) was added to the 1,000 mL flask and the resulting reaction mixture was recycled though a UV lamp reactor. The reaction mixture was kept at 0-20 C. and the recycling was continued until the reaction was deemed complete by HPLC. Optionally, additional sodium bromate and hydrogen bromide may be added. The relative amounts of Compound 2 and Compound 3 were about 80-90% and about 10-20% respectively. Aqueous sodium metabisulfite solution (2.0 g of in 10 mL water) was added to the reaction mixture. Allow the phases to settle and the methylene chloride phase was washed with water and used in the next step without further purification.

The synthetic route of 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Miranda, Edgar I.; Vlaar, Cornelis; Zhu, Jingyang; US2006/41147; (2006); A1;,
Nitrile – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, A new synthetic method of this compound is introduced below., Formula: C14H11N

Example 2: Production of CBAL (1) To monochlorobenzene (450 g) was added CMB (300 g, 1.55 mol), and solution prepared by dissolving sodium bromate (50.1 g, 0.33 mol) in 95.3 g of water was added. 2,2′-azobis(2-methylbutyronitrile)(2.0 g, 0.01 mol) was dissolved in monochlorobenzene(10g), and this solution was added to the above-mentioned solution at 75 to 85C, then, immediately, solution prepared by dissolving 2,2′-azobis(2-methylbutyronitrile)(89 g, 0.05 mol) in monochlorobenzene (48.8 g), and bromine (198.5 g, 1.24 mol) were dropped simultaneously respectively at 70 to 80C. The solution of 2,2′-azobis(2-methylbutyronitrile) was dropped at a rate of about 0.22 g/min and bromine was dropped at a rate of about 0.73 g/min. The added solution was stirred for 5 hours at 70 to 75C, and the reaction solution was checked under HPLC analysis conditions (1), and that the area percentage of raw materials reached 1% or less was confirmed, obtaining a mixed solution of CMBMB and CDBMB. The solution was analyzed under the HPLC analysis conditions (1), to find an area percentage of CMBMB of 63.6%, CDBMB of 36.2% and a raw material CMB of 0.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 114772-53-1, The chemical industry reduces the impact on the environment during synthesis 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, I believe this compound will play a more active role in future production and life.

To the glass reactor, 4′-methyl-2-cyanobiphenyl was added5.00 kg, and methanol: 10.00 kgWith stirring2. 07 kg of sodium hydroxide,0.94 kgwaterSolubleliquid,Heated to 80 C, the reaction 10 hours,TLC test (developing solvent = petroleum ether: ethyl acetate = 1: 1), the reaction finished cooling to 40 C, and stirring 20 to 30 minutes, then add hydrochloric acid pH = 2 or so, stirring 30 minutes after the re-test pH , No change will continue to cool down to room temperature, some solid precipitation, continue stirring for two hours, centrifugal, washed to neutral, the product is dry 10 ~ 12 hours, the product 5. 30kg, yield 91. 06%Melting point 146 ~ 148 C, purity 99. 12%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; weite hunan pharmaceutical co ltd; He, liang; Luo, hui; Mo, wei; (10 pag.)CN105399627; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114772-53-1 as follows. 114772-53-1

To a sealed tube were successively added TBAF 3H2O (0.35 g, 1.10 mmol), 4 (0.42 g, 2.20 mmol) and TMSN3 (0.38 g, 3.30 mmol) and the resulting mixture was heated at 120 C for 36 h. The resulting reaction mixture was extracted with EtOAc (30 mL) and TBAF was removed by washing the organic phase with 1 M HCl aqueous solution (3 10 mL). The organic extract was dried (Na2SO4), filtered and concentrated in vacuo. Recrystallization from diisopropyl ether furnished pure 5 (77%) as a white solid: M.p. 145-147 C; Rf 0.57 (CHCl3:MeOH, 9:1); tR 11.54 min (30% MeCN / 100% MeCN in 30 min); ESI-MS (m/z): 237.0 [MH]; 1HNMR(400 MHz, CD3OD): d 7.69-7.64 (m, 2H), 7.56-7.52 (m, 2H), 7.13 (d, 2H, J . 7.8 Hz), 7.00 (d, 2H, J . 7.8 Hz), 2.33 (s, 3H) ppm; 13C NMR (160 MHz, CD3OD): d 155.42, 142.17, 137.43, 136.24, 131.05, 130.39, 130.17, 128.76, 127.27, 122.83, 19.72 ppm.

According to the analysis of related databases, 114772-53-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Agelis, George; Resvani, Amalia; Matsoukas, John; Durdagi, Serdar; Spyridaki, Katerina; Liapakis, George; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Mavromoustakos, Thomas; Vlahakos, Demetrios; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 358 – 374,17;; ; Article; Agelis, George; Resvani, Amalia; Durdagi, Serdar; Spyridaki, Katerina; Tumova, Tereza; Slaninova, Jirina; Giannopoulos, Panagiotis; Vlahakos, Demetrios; Liapakis, George; Mavromoustakos, Thomas; Matsoukas, John; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 358 – 374;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts