Related Products of 1123172-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1123172-88-2, name is 3,5-Difluoro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a 250 ml stainless steel autoclave, 120 g of N,N-dimethylformamide and 18.5 g (0.1 mol) of 3,5-difluoro-4-nitrobenzonitrile were added.15.0 g of potassium carbonate, 6.0 g (0.1 mol) of isopropylamine, sealed in an autoclave, stirred at 60 to 65 C for 5 hours, cooled to 20 to 25 C, the material was removed, filtered, and the filtrate was evaporated under reduced pressure to give a solvent. To 25 C,Add 20 g of methyl tert-butyl ether, filter, and dry.20.7 g of 3-fluoro-4-nitro-5-isopropylaminobenzonitrile (II) were obtained.The yield was 92.8%, and the liquid phase purity was 99.5%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Difluoro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Xin Fa Pharmaceutical Co., Ltd.; Qi Yuxin; Liu Yuesheng; Zhu Chengchen; Zhang Mingfeng; Wang Tao; (14 pag.)CN110218189; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts