Category: 1080-74-6

1080-74-6, Adding some certain compound to certain chemical reactions, such as: 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1080-74-6.

To a degassed solution of intermediate 49 (250 mg, 0.19 mmol) in a mixture of pyridine (2 cm3) and chloroform (18 cm3) at 0 C is added 2-(3- oxo-indan-1 -ylidene)-malononitrile (1 12 mg, 0.58 mmol) is added and the mixture stirred at 0 C for 3 hours. The reaction is quenched by addition of aqueous hydrochloric acid solution (10 cm3, 2 M) and the aqueous layer extracted with dichloromethane (20 cm3). The combined organic layer is washed with brine (50 cm3), dried over anhydrous magnesium sulphate, filtered and the solvent removed in vacuo. This residue is purified by column chromatography using a graded solvent system (40-60 petrol:dichloromethane; 3:2 to 3:7). The solid is triturated in ice-cooled acetone (30 cm3) and with diethylether (20 cm3) to give compound 104 (135 mg, 42%) as a blue solid. 1H NMR (400 MHz, CD2CI2) 8.85 (2H, s), 8.67 (2H, d, J 7.5), 8.24 (2H, s), 7.95 (4H, t, J 9.2), 7.75 – 7.83 (4H, m), 7.59 (2H, d, J 8.3), 7.23 (8H, d, J 8.4), 6.83 (8H, d, J 8.4), 3.87 (8H, t, J 6.6), 1 .63 – 1 .74 (8H, m), 1 .31 – 1 .39 (8H, m), 1 .18 – 1 .31 (32H, m), 0.82 (12H, t, J 7.0).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1080-74-6.

Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1080-74-6.

EXAMPLE 11 Cvclization to Form Dihvdropyridine 16 (R = 2-fury, R3=H) To a solution of 3-dicyanovinylindan-1-one (4.06 g, 20.9 mmol) in 200 mL of ethanol was added 2-furaldehyde (3.01 g, 31.4 mmol) and 25 mL of conc. NH40H. The solution was heated to reflux for 2 h and allowed to cool to rt overnight. The mixture was concentrated in vacuo to remove ethanol. The residue was filtered and washed with water. The purple solid obtained was dried to yield 5.92 g (89%).

The synthetic route of 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORTHO-MCNEIL PHARMACEUTICAL, INC.; WO2005/42500; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 1080-74-6

The specific operation is as follows: adding the above dialdehyde structural compound 17 (0.20 g) to a 100 mL two-necked bottle,The terminal group 1 (0.21 g), 40 ml of dry chloroform and pyridine (1 ml) were reacted at room temperature for 24 hours.The organic phase was extracted with chloroform, dried over anhydrous sodium sulfate and evaporated.Column chromatography separationBlue-black solid compound 6 (0.25 g, yield 84%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1080-74-6, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nankai University; Chen Yongsheng; Qiu Nailiang; Zhang Huijing; Feng Huanran; (32 pag.)CN108864135; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts