Category: 105942-08-3

In 2018,Yang, Xicheng; Yu, Haihua; Xu, Yulong; Shao, Liming published 《Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles》.Journal of Organic Chemistry published the findings.Reference of 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

A novel and regioselective Ni(I) catalyzed C-C and C-N cascade coupling reactions has been developed. The cascade furnishes atom-economic access to 40 3-aryl-1-aminoisoquinolines I (R1 = H, 7-Me, 6-MeO, 7-F, etc.; R2 = H, Me, Et, Ph, etc.; R3 = H, 4-F, 2-Me, 3-F, etc.). The regioselectivity of C(sp3)-cyano group over C(sp2)-cyano group was revealed and supported by mechanism studies as well as the preliminary d. functional theory (DFT) calculations In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Pyrrolopyrimidine vs. Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase》 were Revuelto, Alejandro; Ruiz-Santaquiteria, Marta; de Lucio, Hector; Gamo, Ana; Carriles, Alejandra A.; Gutierrez, Kilian Jesus; Sanchez-Murcia, Pedro A.; Hermoso, Juan A.; Gago, Federico; Camarasa, Maria-Jose; Jimenez-Ruiz, Antonio; Velazquez, Sonsoles. And the article was published in ACS Infectious Diseases in 2019. Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

Disruption of protein-protein interactions of essential oligomeric enzymes by small mols. represents a significant challenge. We recently reported some linear and cyclic peptides derived from an α-helical region present in the homodimeric interface of Leishmania infantum trypanothione reductase (Li-TryR) that showed potent effects on both dimerization and redox activity of this essential enzyme. Here, we describe our first steps toward the design of nonpeptidic small-mol. Li-TryR dimerization disruptors using a proteomimetic approach. The pyrrolopyrimidine and the 5-6-5 imidazole-phenyl-thiazole α-helix-mimetic scaffolds were suitably decorated with substituents that could mimic three key residues (K, Q, and I) of the linear peptide prototype (PKIIQSVGIS-Nle-K-Nle). Extensive optimization of previously described synthetic methodologies was required. A library of 15 compounds bearing different hydrophobic alkyl and aromatic substituents was synthesized. The imidazole-phenyl-thiazole-based analogs outperformed the pyrrolopyrimidine-based derivatives in both inhibiting the enzyme and killing extracellular and intracellular parasites in cell culture. The most active imidazole-phenyl-thiazole compounds 3e and 3f inhibit Li-TryR and prevent growth of the parasites at low micromolar concentrations similar to those required by the peptide prototype. The intrinsic fluorescence of these compounds inside the parasites visually demonstrates their good permeability in comparison with previous peptide-based Li-TryR dimerization disruptors. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Zhen, Qianqian; Chen, Lepeng; Qi, Linjun; Hu, Kun; Shao, Yinlin; Li, Renhao; Chen, Jiuxi. Reference of 4-Bromo-2-fluorobenzonitrile The article mentions the following:

The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles R1-2-(NCCH(R2))C6H3CN (R1 = H, 4-Me, 6-Ph, 5-Br, etc.; R2 = H, Ph, thiophen-3-yl, i-Pr, etc.) with arylboronic acids ArB(OH)2 (Ar = Ph, thiophen-3-yl, benzo[d][1,3]dioxol-5-yl, etc.) in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines I (R1 = H, 6-Me, 8-Ph, 7-Br, etc.) with good functional group tolerance under mild conditions. This chem. has also been successfully applied to the synthesis of isoquinolones II by the tandem reaction of Me 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chem. is also indicated by the synthesis of biol. active mols. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Reference of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 105942-08-3In 2018 ,《Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Liu, Jian; Qian, Chengbo; Zhu, Yehua; Cai, Jianguo; He, Yufang; Li, Jie; Wang, Tianlin; Zhu, Haohao; Li, Zhi; Li, Wei; Hu, Lihong. The article conveys some information:

Both histone deacetylase (HDAC) and fibroblast growth factor receptor (FGFR) are important targets for cancer therapy. Although combining dual HDAC pharmacophore with tyrosine kinase inhibitors (TKIs) had achieved a successful progress, dual HDAC/FGFR1 inhibitors haven’t been reported yet. Herein, we designed a series of hybrids bearing 1H-indazol-3-amine and benzohydroxamic acids scaffold with scaffold hopping and mol. hybridization strategies. Among them, compound 7j showed the most potent inhibitory activity against HDAC6 with IC50 of 34 nM and exhibited the great inhibitory activities against a human breast cancer cell line MCF-7 with IC50 of 9 μM in vitro. Meanwhile, the compound also exhibited moderate FGFR1 inhibitory activities. This study provides new tool compounds for further exploration of dual HDAC/FGFR1 inhibition. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets》 was written by Lutter, Ferdinand H.; Grokenberger, Lucie; Perego, Luca Alessandro; Broggini, Diego; Lemaire, Sebastien; Wagschal, Simon; Knochel, Paul. COA of Formula: C7H3BrFN And the article was included in Nature Communications in 2020. The article conveys some information:

The metalation of 1-aryl-1H-1,2,3-triazoles and other related heterocycles with sterically hindered metal-amide bases were investigated. A room temperature and highly regioselective ortho-magnesiation of several aryl azoles using a tailored magnesium amide, TMPMgBu (TMP = 2,2,6,6-tetramethylpiperidyl) in hydrocarbon solvents followed by an efficient Pd-catalyzed arylation was reported. This scalable and selective reaction allows variation of the initial substitution pattern of the aryl ring, the nature of the azole moiety, as well as the nature of the electrophile. This versatile method can be applied to the synthesis of bioactive azole derivatives and complements existing metal-mediated ortho-functionalizations. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.COA of Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lai, Liming; Fang, Bing; Fan, Mingyu; Cheng, Wenyu; Yin, Meizhen published an article in 2021. The article was titled 《Modulating Room-Temperature Phosphorescence through the Synergistic Effect of Heavy-Atom Effect and Halogen Bonding》, and you may find the article in Journal of Physical Chemistry C.Synthetic Route of C7H3BrFN The information in the text is summarized as follows:

Organic room-temperature phosphorescence (RTP) materials have been paid great attention for their promising applications in anticounterfeiting, optical device, and bioimaging. However, owing to inefficient intersystem crossing (ISC), it still remains a challenge to develop organic RTP materials with both high quantum yields (Φp) and long lifetime (τp). Herein, a reasonable strategy is presented to modulate and balance the Φp and τp through the synergy effect of halogen bonding and heavy-atom effect (HAE). Modulated RTP properties are successfully achieved by the introduction of halogen atoms into 4-(9-H-carbazol-9-yl) benzonitrile due to enhanced ISC. Especially, CzBzBr shows the highest Φp of 23.50% and CzBzCl exhibits the longest τp of 607.4 ms. The excessive HAE of the bromine atom decreases the τp of CzBzBr, while moderate HAE of the chlorine atom endows CzBzCl with both high Φp and long τp. In addition, the halogen bondings lead to specific halogen-mediated mol. cluster packing, further suppressing nonradiative transition for ultralong RTP emission. Through simple phys. co-crystallization with adjusting the mass ratio of CzBzCl/CzBzBr, co-crystals with modulated RTP properties and white-light emission phenomena are obtained. Our study provides a rationale method to develop modulated high-efficiency RTP materials, which will expand their practical applications.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Synthetic Route of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zheng, Yuanqin; Zhou, Yuqiao; Zhang, Yan; Deng, Pengchi; Zhao, Xiaohu; Jiang, Shichao; Du, Guangxi; Shen, Xin; Xie, Xinyu; Su, Zhishan; Yu, Zhipeng published an article in Chemistry – An Asian Journal. The title of the article was 《Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “”Photo-Clicked”” Access to Carbamoyl Formazan Photoswitches In Situ》.Electric Literature of C7H3BrFN The author mentioned the following in the article:

A “”photo-click”” method that involved nitrile imine from diarylsydnone to capture diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD was described. DFT calculation revealed that H-bonding interactions between PTAD and water were vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit anal. (NBO). The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z <-> E photo-switchable linker on target mols., including peptide and drugs, with excellent anti-fatigue performance. This strategy was showcased to construct highly functionalized carbamoyl formazans such as I [R = H, 4-F, 4-Ph, etc.; R1 = 4-CF3, 3-CN, etc.; R2 = H, 4-F, 4-MeO, etc.] in situ for photo-pharmacol. and material studies, which also expanded chem. of PTAD in aqueous media.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Electric Literature of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Zhou, Qiang; Zhu, Jinjin; Chen, Jinglei; Ji, Peng; Qiao, Chunhua published 《N-Arylsulfonylsubstituted-1H indole derivatives as small molecule dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and tubulin》.Bioorganic & Medicinal Chemistry published the findings.Computed Properties of C7H3BrFN The information in the text is summarized as follows:

Signal transducer and activator of transcription (STAT3) is a proposed therapeutic target for the development of anti-cancer agents. In this report, a series of N-arylsulfonylsubstituted-1H indole derivatives were designed and synthesized as STAT3 inhibitors, their anti-proliferative activities were evaluated against a number of tumor cells, some potent compounds exhibited IC50 values less than 10μM. The most potent compound 4a was further confirmed to inhibit STAT3 phosphorylation at Tyr705. It was further revealed that 4a arrested the cell cycle at the G2/M phase and inhibited tubulin polymerization This study describes a series of N-arylsulfonylsubstituted-1H indole derivatives as potent anti-cancer agents targeting both STAT3 and tubulin. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Computed Properties of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Computed Properties of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 105942-08-3In 2018 ,《Palladium-Catalyzed Tandem Reaction of Quinazolinone-Based Nitriles with Arylboronic Acids: Synthesis of 2-(4-Arylquinazolin-2-yl)anilines》 appeared in Advanced Synthesis & Catalysis. The author of the article were Zhang, Yetong; Shao, Yinlin; Gong, Julin; Hu, Kun; Cheng, Tianxing; Chen, Jiuxi. The article conveys some information:

A palladium-catalyzed tandem reaction of 2-(quinazolinone-3(4H)-yl)benzonitriles with arylboronic acids has been developed, allowing access to a class of 2-(4-arylquinazolin-2-yl)anilines that were often difficult to prepare using previous methods. In particular, the newly produced amino group is amenable to further synthetic elaborations, thereby broadening the diversity of the products. The structure of the newly synthesized 2-(4-arylquinazolin-2-yl)anilines was unambiguously confirmed by X-ray crystallog. Moreover, a possible mechanism for the formation of 2-(4-arylquinazolin-2-yl)anilines is discussed. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Related Products of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Related Products of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Kong, Weiguang; Zhou, Yao; Song, Qiuling published 《Lewis-acid Promoted Chemoselective Condensation of 2-Aminobenzimidazoles or 3-Aminoindazoles with 3-Ethoxycyclobutanones to Construct Fused Nitrogen heterocycles》.Advanced Synthesis & Catalysis published the findings.Name: 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

A Lewis-acid promoted chemoselective condensation of 2-aminobenzimidazoles YNH2 (Y = benzoimidazol-2-yl, 5-fluoro-1H-benzoimidazol-2-yl, 5,6-diphenyl-1H-benzoimidazol-2-yl, etc.) or 3-aminoindazoles Y1NH2 (Y1 = 1H-indazol-3-yl, 1H-pyrazolo[3,4-b]pyridin-3-yl, 4-cyano-1H-pyrazole-3-yl, etc.) with 3-ethoxycyclobutanones I (R = H, CH3; X = CH3CHCH3, cyclobutanyl, phenylethyl, etc.) was presented. Diverse fused heterocycles benzo[4,5]-imidazo[1,2-a]pyrimidines II (R1 = H, 7-F, 8-Cl, 7,8-(C6H5)2, etc.) and pyrimido[1,2-b]-indazole derivatives III (R2 = CN, C(O)OCH2CH3, C(O)NH2; R2, R3 = -CH=CH-CH=CH-, -CH=C(OCH3)-CH=CH-, -CH=CH-CH=NH-, etc.) were obtained in moderate to high yields under mild conditions, and the reaction mechanism of which was in sharp contrast to previous [3+3] annulation reaction of 3-ethoxycyclobutanones. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Name: 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts