Category: 105942-08-3

Aretz, Christopher D.; Kharade, Sujay V.; Chronister, Keagan; Rusconi Trigueros, Renata; Martinez Rodriguez, Erick J.; Piermarini, Peter M.; Denton, Jerod S.; Hopkins, Corey R. published an article in 2021. The article was titled 《Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides》, and you may find the article in ChemMedChem.Synthetic Route of C7H3BrFN The information in the text is summarized as follows:

Zika virus (ZIKV), dengue fever (DENV) and chikungunya (CHIKV) are arboviruses that are spread to humans from the bite of an infected adult female Aedes aegypti mosquito. As there are no effective vaccines or therapeutics for these diseases, the primary strategy for controlling the spread of these viruses is to prevent the mosquito from biting humans through the use of insecticides. Unfortunately, the commonly used classes of insecticides have seen a significant increase in resistance, thus complicating control efforts. Inhibiting the renal inward rectifier potassium (Kir) channel of the mosquito vector Aedes aegypti has been shown to be a promising target for the development of novel mosquitocides. We have shown that Kir1 channels play key roles in mosquito diuresis, hemolymph potassium homeostasis, flight, and reproduction Previous work from our laboratories identified a novel (phenylsulfonyl)piperazine scaffold as potent AeKir channel inhibitors with activity against both adult and larval mosquitoes. Herein, we report further the synthesis and SAR work around this scaffold and have identified addnl. compounds, e.g., I and II, with improved in vitro potency and mosquito larvae toxicity. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Synthetic Route of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Stevens, Jason M.; Li, Jun; Simmons, Eric M.; Wisniewski, Steven R.; DiSomma, Stacey; Fraunhoffer, Kenneth J.; Geng, Peng; Hao, Bo; Jackson, Erika W. published an article in Organometallics. The title of the article was 《Advancing Base Metal Catalysis through Data Science: Insight and Predictive Models for Ni-Catalyzed Borylation through Supervised Machine Learning》.Application of 105942-08-3 The author mentioned the following in the article:

An expansive data set containing 33 substrates, 36 unique monophosphine ligands, and two solvents was produced for the NiCl2·6H2O catalyzed aryl (pseudo)halide borylation with tetrahydroxydiboron for a total of 1632 reactions. Exploratory data anal. revealed excellent reaction performance with simple triarylphosphines (P(p-F-Ph)3 and P(p-Anis)3) and mixed aryl-alkyl phosphines (PPh2Cy), in addition to the previously established high performance with Cy-JohnPhos. The data were used to train machine learning models that predicted out of sample reaction performance with a root-mean-square error of 18.4. The important features extracted from the models identified three phosphine parameters that offered reliable reactivity thresholds for identifying optimal ligand performance. The predictive models showed reasonable performance for predicting reaction yields employing ligands not included in model training, while the important feature boundaries accurately classified the performance of 10 of the 12 external ligands examined4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Application of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Hammann, Jeffrey M.; Thomas, Lucie; Chen, Yi-Hung; Haas, Diana; Knochel, Paul published 《Cobalt-Catalyzed Cross-Couplings of Bench-Stable Alkynylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides》.Organic Letters published the findings.Product Details of 105942-08-3 The information in the text is summarized as follows:

In the presence of CoCl2·2LiCl and TMEDA, selected terminal alkynylzinc pivalates underwent coupling with electron-deficient aryl and heteroaryl chlorides, bromides, and iodides and two alkenyl bromides to yield aryl alkynes and enynes chemoselectively; coupling of a silylethynylzinc pivalate with an (E)-alkenyl bromide and a (Z)-bromoacrylate yielded the corresponding (E)-enyne and (Z)-enynoate in 99:1 dr. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Product Details of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《High-Contrast Polymorphic Luminogen Formed through Effect of Tiny Differences in Intermolecular Interactions on the Intramolecular Charge Transfer Process》 was published in Advanced Optical Materials in 2020. These research results belong to Wang, Kang; Xie, Yujun; Liu, Ming; Tao, Wei; Zhang, Hao; Huang, Meidong; You, Jinmao; Liu, Ying; Li, Yunliang; Li, Zhen; Dong, Yong Qiang. Category: nitriles-buliding-blocks The article mentions the following:

Polymorphic luminogens provide the opportunity to disclose relation between the packing patterns and performance of luminogen and facilitate design of high performance luminogens. However, the effect of intramol. charge transfer (ICT) is seldom used to construct luminogens with polymorphs, though the ICT process is very sensitive to microenvironment. In this work, 2-(3-(diphenylamino)-9H-xanthen-9-ylidene)-malononitrile (DPAXM, 1) with donor-acceptor structure exhibits high contrast polymorphism dependent emission due to the effect of tiny differences of intermol. interactions on ICT process. Three crystals of 1 with nearly identical structures emit yellow, orange, and red light with sequentially decreased efficiency which is attributed to ICT process modulated by the tiny differences in intermol. interactions. In addition to ground state study, excited state of the polymorphs is investigated by time-resolved ultrafast transient mid-IR spectroscopy and theor. calculation Nonemissive crystals of 1 can also be obtained. The modulation of ICT effect by intermol. interactions may provide a reference for the mol. design of high-performance luminogens. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Category: nitriles-buliding-blocks 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Yuan, Shou; Zhang, Yuefa; Chen, Junwu; Yu, Yuan; Yue, Lingtai; Sun, Qikun; Zhang, Haichang; Xue, Shanfeng; Yang, Wenjun published an article in Advanced Optical Materials. The title of the article was 《Effectively Unlocking the Potential Molecular Room Temperature Phosphorescence of Pure Carbazole Derivatives》.Formula: C7H3BrFN The author mentioned the following in the article:

The current prevailing views are that carbazole derivatives without isomers show inferior room temperature phosphorescence (RTP) and that N-aryl carbazole derivatives exhibit no ultralong RTP in dilute film states since the distorted structures easily dissipate the excitation energy. In the current work, we present that doping N-aryl carbazole derivatives with heteroatoms and/or heavy halogen into PMMA at the mol. level by thermoplasticizing solution-cast films can achieve ultra-long-lived (>1 s) and highly-efficient (>36%) mol. RTP without the need of crystallization and isomer doping. Unlike isomer-doped crystals that almost all emit yellow RTP, the RTP colors of doped PMMA films depend on the mol. structures of carbazole derivatives Also, we can realize highly efficient and long-lived red fluorescence afterglow via persistent Forster resonance energy transfer from RTP emission to fluorescent emitter. These colorful afterglow polymer films exhibit an ultra-long (>20 h) photo-activation pattern memory effect. This work has challenged existing exptl. results and relative RTP mechanisms, providing a reasonable processing strategy for manifesting and enhancing the deserved RTP properties of organic doped polymers. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Formula: C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Cobalt-catalyzed acylation-reactions of (hetero)arylzinc pivalates with thiopyridyl ester derivatives》 was written by Lutter, Ferdinand H.; Grokenberger, Lucie; Hofmayer, Maximilian S.; Knochel, Paul. Product Details of 105942-08-3This research focused onthiopyridyl ester hetero arylzinc pivalate acylation catalyst; aryl ketone preparation. The article conveys some information:

A cobalt-catalyzed acylation reaction of various primary, secondary and tertiary alkyl, benzyl and (hetero)aryl S-pyridyl thioesters with (hetero)arylzinc pivalates was reported. The thioesters were prepared directly from the corresponding carboxylic acids under mild conditions, thus tolerating sensitive functional groups. Acylations of α-chiral S-pyridyl esters proceeded with very high stereoretention leaded to optically enriched α-chiral ketones.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Product Details of 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Product Details of 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Szilvasi, Tibor; Roling, Luke T.; Yu, Huaizhe; Rai, Prabin; Choi, Sangwook; Twieg, Robert J.; Mavrikakis, Manos; Abbott, Nicholas L. published 《Design of Chemoresponsive Liquid Crystals through Integration of Computational Chemistry and Experimental Studies》.Chemistry of Materials published the findings.Recommanded Product: 105942-08-3 The information in the text is summarized as follows:

We report the use of computational chem. methods to design a chem. responsive liquid crystal (LC). Specifically, we used electronic structure calculations to model the binding of nitrile-containing mesogens (4′-n-pentyl-4-biphenylcarbonitrile) to metal perchlorate salts (with explicit description of the perchlorate anion), which we call the coordinately saturated anion model (CSAM). The model results were validated against exptl. data. We then used CSAM to predict that selective fluorination can reduce the strength of binding of nitrile-containing nematic LCs to metal salt-decorated surfaces and thus generate a faster reordering of LC in response to competitive binding of dimethylmethylphosphonate (DMMP). We tested this prediction via synthesis of fluorinated compounds 3-fluoro-4′-pentyl[1,1′-biphenyl]-4-carbonitrile and 4-fluoro-4′-pentyl-1,1′-biphenyl, and subsequent exptl. measurements of the orientational response of LCs containing these compounds to DMMP. These exptl. measurements confirmed the theor. predictions, thus providing the first demonstration of a chemoresponsive LC system designed from computational chem. The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Recommanded Product: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Yan; Xia, Mingze; Li, Min; Ping, Qian; Yuan, Zhenbo; Liu, Xuanzhong; Yin, Huimin; Huang, Shuping; Rao, Yijian published an article in 2021. The article was titled 《Energy-transfer-mediated photocatalysis by a bioinspired organic perylene photosensitizer HiBRCP》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 105942-08-3 The information in the text is summarized as follows:

Energy transfer plays a special role in photocatalysis by utilizing the potential energy of the excited state through indirect excitation, in which a photosensitizer determines the thermodn. feasibility of the reaction. Bioinspired by the energy-transfer ability of natural product Cercosporin, here we developed a green and highly efficient organic photosensitizer HiBRCP (hexaisobutyryl reduced Cercosporin) through structural modification of Cercosporin. After structural manipulation, its triplet energy was greatly improved, and then, it could markedly promote the efficient geometrical isomerization of alkenes from the E-isomer to the Z-isomer. Moreover, it was also effective for energy-transfer-mediated organometallic catalysis, which allowed realization of the cross-coupling of aryl bromides and carboxylic acids through efficient energy transfer from HiBRCP to nickel complexes. Thus, the study on the relationship between structural manipulation and their photophys. properties provided guidance for further modification of Cercosporin, which could be applied to more meaningful and challenging energy-transfer reactions. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3SDS of cas: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.SDS of cas: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Sang, Yali; Han, Sheng; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fener. HPLC of Formula: 105942-08-3. The article was titled 《Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles》. The information in the text is summarized as follows:

A series of nondimethylphenyl-diarylpyrimidines with much lower cytotoxicities than their di-Me analogs were developed. Compound B13 with a difluorobiphenyl moiety showed the highest antiviral activity against WT, mutant strains, and RT. The hydrochloride form of B13 exhibited an improved water solubility of 5.6μg/mL compared with ETR (≪1μg/mL), better stability in human and rat liver microsomes, and a great oral bioavailability of 44%, making it promising as a drug candidate. In addition, no apparent toxicity was observed in the acute toxicity assay (2 g/kg) and HE staining.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3HPLC of Formula: 105942-08-3) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.HPLC of Formula: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 105942-08-3In 2017 ,《Experimental investigation of the influence of reaction atmosphere on the pyrolysis of printed circuit boards》 appeared in Applied Energy. The author of the article were Evangelopoulos, Panagiotis; Kantarelis, Efthymios; Yang, Weihong. The article conveys some information:

Printed circuit boards (PCB) are one of the most challenging fractions of waste elec. and electronic equipment (WEEE) in terms of recycling due to their complexity and diversity. Pyrolysis seems to be a promising alternative for production of energy carriers from its organic fraction with simultaneous recovery of metals. Reaction atm. is among the process parameters that affects the thermal decomposition as well as the products formation and distribution. In this study, the decomposition of two different PCB fractions in inert and steam atmospheres has been investigated by means of thermogravimetric anal. (TGA) and lab scale fixed bed reactor experiments It was found that the decomposition of the tested materials in steam atm. starts at lower temperatures and proceeds slower compared to the N2 atmosphere. Moreover, a two-step decomposition has been observed on the PCB sockets fraction due to the fact that high amount of antimony oxide was present, a common additive for improving the flame retardancy, which have been also observed on previous studies (Wu et al., 2014). The presence of steam influence the pyrolysis gas composition and promotes addnl. vaporisation of antimony as verified by powder X-ray diffraction (XRD) and SEM (SEM). Finally, the liquid fraction has been qual. analyzed using a GC/MS in order to determine the brominated compounds as well as other compounds that are produced from this process. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts