Category: 105942-08-3

In 2017,Greiner, Robert; Ziegler, Dorothee S.; Cibu, Denise; Jakowetz, Andreas C.; Auras, Florian; Bein, Thomas; Knochel, Paul published 《Preparation of Polyfunctional Naphthyridines by Cobalt-Catalyzed Cross-Couplings of Halogenated Naphthyridines with Magnesium and Zinc Organometallics》.Organic Letters published the findings.COA of Formula: C7H3BrFN The information in the text is summarized as follows:

CoCl2 (5%) catalyzes cross-couplings of various halogenated naphthyridines with alkyl- and arylmagnesium halides. Also, arylzinc halides undergo smooth cross-couplings with various naphthyridines in the presence of CoCl2·2LiCl (5%) and sodium formate (50%), leading to polyfunctional arylated naphthyridines. Two of these arylated naphthyridines, e. g., I, are highly fluorescent, with quantum efficiencies reaching 95% and long excited-state lifetimes of up to 12 ns. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.COA of Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Name: 4-Bromo-2-fluorobenzonitrileIn 2020 ,《Substrate profiling of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870》 was published in Molecules. The article was written by Mashweu, Adelaide R.; Chhiba-Govindjee, Varsha P.; Bode, Moira L.; Brady, Dean. The article contains the following contents:

The aromatic substrate profile of the cobalt nitrile hydratase from Rhodococcus rhodochrous ATCC BAA 870 was evaluated against a wide range of nitrile containing compounds (>60). To determine the substrate limits of this enzyme, compounds ranging in size from small (90 Da) to large (325 Da) were evaluated. Larger compounds included those with a bi-aryl axis, prepared by the Suzuki coupling reaction, Morita-Baylis-Hillman adducts, heteroatom-linked diarylpyridines prepared by Buchwald-Hartwig cross-coupling reactions and imidazo[1,2-a]pyridines prepared by the Groebke-Blackburn-Bienayme multicomponent reaction. The enzyme active site was moderately accommodating, accepting almost all of the small aromatic nitriles, the diarylpyridines and most of the bi-aryl compounds and Morita-Baylis-Hillman products but not the Groebke-Blackburn-Bienayme products. Nitrile conversion was influenced by steric hindrance around the cyano group, the presence of electron donating groups (e.g., methoxy) on the aromatic ring, and the overall size of the compound4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Name: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Zhao, Rongrong; Wen, Simiaomiao; Fu, Hao; Liu, Mengna; Liu, Qixing; Zhou, Haifeng published an article in Green Chemistry. The title of the article was 《Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen》.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

A simple, efficient and clean approach for the synthesis of diverse dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones and analogs through intramol. acceptorless dehydrogenative coupling has been achieved. The combination of bis(2-methoxyethyl)ether and mol. oxygen was identified as a highly efficient system for this oxidative dehydrogenative coupling sequential transformation without an external initiator, catalyst and additive. The applicability and practicability were demonstrated by a scope of twenty-nine examples and a gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Application In Synthesis of 4-Bromo-2-fluorobenzonitrile) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Application In Synthesis of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Dziaduszek, J.; Dabrowski, R.; Urban, S.; Garbat, K.; Glushchenko, A.; Czuprynski, K. published 《Selected fluorosubstituted phenyltolanes with a terminal group: NCS, CN, F, OCF3 and their mesogenic and dielectric properties and use for the formulation of high birefringence nematic mixtures to GHz and THz applications》.Liquid Crystals published the findings.Computed Properties of C7H3BrFN The information in the text is summarized as follows:

Thirty laterally fluorosubstituted new 4-isothiocyanato-, 4-cyano-, 4-fluoro- and 4-(1,1,1-trifluorometoxy)-4′-(4-alkylphenyl)tolanes have been synthesized and their phase transition temperatures and enthalpies and elec. permittivity have been measured. These data have been analyzed together with data for earlier prepared similar compounds and with recently prepared analogously substituted 4″”-alkyl-terphenyls. It was shown that some di-, tri- and tetra-fluorosubstituted 4-isothiocyanato- and 4-cyano-4′-(4-alkylphenyltolanes) are very useful components for the formulation of high birefringence (Δn up to 0.5 measured at 589 nm) and large temperature range nematic mixtures for photonic applications, especially in the infra-red, GHz and THz range of electromagnetic radiation. Three ways of formulation of high birefringence mixtures were proposed. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Computed Properties of C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Computed Properties of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ansari, Tharique N.; Sharma, Sudripet; Bora, Pranjal P.; Ogulu, Deborah; Parmar, Saurav; Gallou, Fabrice; Kozlowski, Pawel M.; Handa, Sachin published their research in ChemSusChem in 2021. The article was titled 《Photoassisted Charge Transfer Between DMF and Substrate: Facile and Selective N,N-Dimethylamination of Fluoroarenes》.Name: 4-Bromo-2-fluorobenzonitrile The article contains the following contents:

A reversible Van der Waals complex formation between the electron-deficient fluorinated aromatic ring and N,N-dimethylformamide (DMF) mols. followed by light irradiation resulted in charge transfer (CT) process. The complex was stabilized by ammonium formate and further decomposed to form the C-N bond. Control experiments revealed that the simultaneous SNAr pathway also contributes to product formation. This methodol. is mild, metal-free, and effective for the amination of a variety of substrates. The reproducibility of this methodol. was also verified on gram-scale reactions. The CT states were supported by control UV/Vis spectroscopy and computational studies. Thus, e.g., perfluoronaphthalene + DMF → 2-(dimethylamino)-1,3,4,5,6,7,8-heptafluoronaphthalene (90%, 80% isolated) in presence of ammonium formate additive under white light, together with 2-amino-1,3,4,5,6,7,8-heptafluoronaphthalene as byproduct (10%). The experimental part of the paper was very detailed, including the reaction process of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Name: 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of C7H3BrFNIn 2019 ,《Highly efficient yellow nondoped thermally activated delayed fluorescence OLEDs by utilizing energy transfer between dual conformations based on phenothiazine derivatives》 was published in Dyes and Pigments. The article was written by Xiang, Songpo; Guo, Runda; Huang, Zhi; Lv, Xialei; Sun, Shuaiqiang; Chen, Hongting; Zhang, Qing; Wang, Lei. The article contains the following contents:

The nondoped thermally activated delayed fluorescence (TADF) devices are increasingly attracting attention due to the superior performances and simple fabrication process. By incorporating two acceptors with phenothiazine, two materials 2-(10H-phenothiazine-10-yl)-10-phenyl-10H-phenothiazine-5,5-dioxide (PTZ-2PTO) and 3-(10H-phenothiazin-10-yl)-10-phenylacridin-9(10H)-one (PTZ-AD) are designed and investigated. Both the two materials possess dual conformations, whereas the quasi-axial conformer is the main configuration of PTZ-2PTO and quasi-equatorial conformer of PTZ-AD is more stable. The quasi-axial conformers show classical fluorescence emission, and the quasi-equatorial conformers exhibit TADF characteristic. Fascinatingly more, efficient energy transfer can be achieved between quasi-axial conformers and quasi-equatorial conformers, exhibiting similar mechanism to the traditional host-guest system. Based on this characteristic, yellow nondoped TADF-OLED device of PTZ-AD has realized the efficiency of up to 17.08%, 50.48 cd A-1 and 60.04 lm W-1. Meanwhile, the PTZ-AD based nondoped device exhibits low turn-on voltage and low efficiency roll-off, which is among the best performance for yellow nondoped TADF devices. In addition, PTZ-AD based doped device realizes high efficiency of 20.23%, 61.04 cd A-1 and 68.45 lm W-1. This dual conformations forming host-guest system provides a new strategy for obtaining highly efficient nondoped OLEDs devices. After reading the article, we found that the author used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Electric Literature of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Electric Literature of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Garcia-Lopez, Victor; Alemany, Lawrence B.; Chiang, Pinn-Tsong; Sun, Jiuzhi; Chu, Pin-Lei; Marti, Angel A.; Tour, James M. published 《Synthesis of light-driven motorized nanocars for linear trajectories and their detailed NMR structural determination》.Tetrahedron published the findings.Formula: C7H3BrFN The information in the text is summarized as follows:

The design and synthesis of a fluorescent light-driven motorized nanocar with a linear geometry is described. Due to its structural design, the nanocar is present as a mixture of two photo-interconvertible diastereomers. An extensive and detailed NMR study allowed the full assignment of the chem. shifts of the two diastereomers in the mixture The nanocar is expected to translate in a linear motion due to the light-driven motor providing a paddle-wheel like propulsion. The quantum yield of 0.56 and the photostability of the dye make this nanocar suitable for future single-mol. fluorescence microscopy studies. In addition to this study using 4-Bromo-2-fluorobenzonitrile, there are many other studies that have used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN) was used in this study.

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 4-Bromo-2-fluorobenzonitrileIn 2019 ,《Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1)》 was published in Bioorganic Chemistry. The article was written by Liu, Tianqi; Jin, Jing; Chen, Yonghui; Xi, Qiumu; Hu, Jinping; Jia, Wenqiang; Chen, Xiaoguang; Li, Yan; Wang, Xiaojian; Yin, Dali. The article contains the following contents:

Agonism of S1P1 receptor has been proven to be responsible for peripheral blood lymphopenia and elicits the identification of various S1P1 modulators. In this paper the authors described a series of oxadiazole-based S1P1 direct-acting agonists disubstituted on terminal benzene ring, with high potency for S1P1 receptor and favorable selectivity against S1P3 receptor. In addition, two representative agents named I and II demonstrated impressive efficacy in lymphocyte reduction along with reduced effect on heart rate when orally administered. Furthermore, these compounds have been shown to possess desired pharmacokinetic (PK) and physicochem. profiles. The binding mode between I and the activated S1P1 model was also studied. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Reference of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2017,Hofmayer, Maximilian S.; Hammann, Jeffrey M.; Lutter, Ferdinand H.; Knochel, Paul published 《Large-Scale Cobalt-Catalyzed Cross-Couplings of Functionalized Bench-Stable Arylzinc Pivalates with (Hetero)Aryl and Alkenyl Halides》.Synthesis published the findings.Recommanded Product: 105942-08-3 The information in the text is summarized as follows:

A robust and scalable CoCl2-catalyzed cross-coupling between functionalized arylzinc pivalates and various electron-poor (hetero)aryl and alkenyl halides is reported. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Recommanded Product: 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yitao; Yao, Wenqiang; Lin, Jian; Gao, Guoliang; Huang, Chang; Wu, Yang published an article in 2021. The article was titled 《Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi》, and you may find the article in Monatshefte fuer Chemie.Recommanded Product: 4-Bromo-2-fluorobenzonitrile The information in the text is summarized as follows:

A novel series of picarbutrazox-inspired oxadiazole hybrids I (R = 4-cyanophenyl, 3,5-dibromophenyl, 3,5-dichloro-4-(3-methoxyphenoxy)phenyl, etc.) was synthesized and the derivatives’ biol. activity against phytopathogenic fungi was investigated. The mols. were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment I. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative I can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection. The experimental process involved the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts